Dynamic mechanical properties of atherosclerotic aorta A correlation between the cholesterol ester content and the viscoelastic properties of atherosclerotic aorta

Independent Determinants of Second Derivative of the Finger Photoplethysmogram among Various Cardiovascular Risk Factors in Middle-Aged Men

“…This study demonstrated, for the first time to our knowledge, that dyslipidemia was independently associated with the b/a. The results of several clinical studies investigating the association between lipid profiles and arterial stiffness are still controversial (19)(20)(21)(22), possibly because of the difference in the duration of vascular exposure to the dyslipidemic state (23,24). However, the relationship between the duration in those suffering from dyslipidemia and the SDPTG cannot be discussed because this information was not available in the present study.…”

Mechanical stress analysis of a rigid inclusion in distensible material: a model of atherosclerotic calcification and plaque vulnerability

“…The lack of sensitivity to material properties is consistent with the results of Williamson et al (37). Previous studies also showed that calcified arteries are less compliant (2,11,16,26,27,30) and that they fail abruptly at lower tension than controls (11,20,30). This is further supported by the finding that mice with extensive aortic calcification due to matrix GLA protein deficiency almost uniformly die prematurely of aortic rupture (24).…”

Structural and biomechanical alterations in rabbit thoracic aortas are associated with the progression of atherosclerosis

“…It is possible that the increased stiffness after years of high cholesterol diet was due to the presence of highly fibrotic and calcified atherosclerotic lesions that would have an elastic modulus comparable to that of bone [27]. Others have found similar changes in short duration studies of rabbits or rats [31-34]. Interestingly, Hayashi et al [8] found that arterial stiffness in rabbits fed a high cholesterol diet for 4-32 weeks did not increase unless there was also considerable calcification and wall thickening, even if the atherosclerosis was highly advanced.…”

“…Finally, Richter and Mittermayer [35] observed that the modulus of volume elasticity of autopsied human aortas was higher in more advanced stages of atherosclerosis. It is possible that the tangential strips of aorta used in some studies [31,32] may behave differently in tests of elasticity than intact cylindrical arterial segments, such as we have used here, since it is difficult to set up isolated strips of tissue in a mechanical state that is comparable to the physiological loading conditions in vivo.…”