“…The best technique discovered so far for the investigations of nucleation phenomena appears to be quasi-elastic light scattering (QELS). This has been applied to the investigation of crystallization for different macromolecular systems (for reviews, see Wilson, 1990;Kam, Shore & Feher, 1978;Carter, Baldwin & Frick, 1988;Bishop, Fredericks, Howard & Sawada, 1992;Kadima, McPherson, Dunn & Jurnak, 1991;Lorber, Skouri, Munch & Gieg6, 1993;Mikol, Hirsh & Gieg6, 1990). We recently applied QELS to the investigation of nucleation and crystallization phenomena in several large macromolecular assemblies that included satellite tobacco mosaic virus (STMV), apoferritin, ferritin and pumpkin seed globulin (Malkin, Cheung & McPherson, 1993;Malkin & McPherson, 1993a,b,c).…”