“…To date, a number of methods have been used to provide information on the earliest stage of the lysozyme crystallization process (i.e., aggregation) including equilibrium ultracentrifugation (Wills et al, 1980), dialysis (Wilson et al, 1996), interferometry (Kim and Myerson, 1994;Albright et al, 1999), light and neutron scattering (Kuehner et al, 1997;Tanaka and Hayakawa, 1999;Georgalis et al, 1999), NMR relaxation dispersion studies (Raeymaekers et al, 1989), and most recently pulsed-gradient spin-echo (PGSE; also known as pulsed field gradient and DOSY) (see Price, 1996Price, , 1997Price, , 1998 NMR diffusion measurements (Price et al, 1999;Price, 2000).…”