Because the traditional virtual design \method of customized clothing has the problems of poor matching between the designed clothing and the user’s body shape and long design time, a virtual design method of customized clothing based on a three-dimensional image is proposed. Through the way of camera imaging, the three-dimensional human model is established by the linear regression method, and the three-dimensional point cloud image of the human body is obtained. The three-dimensional human key points are extracted by shoulder point extraction, neck point extraction, elbow point extraction, and crotch bottom point extraction. According to the key point extraction results, the customized clothing is registered with the three-dimensional human model. The simulation results show that the proposed method has good matching with the user’s body shape and short design time.