Dynamic imaging of perfusion in human skeletal muscle during exercise with arterial spin labeling

Frank, Lawrence R.; Wong, Eric C.; Haseler, Luke J.; Buxton, Richard B.

doi:10.1002/(sici)1522-2594(199908)42:2<258::aid-mrm7>3.0.co;2-e

Cited by 104 publications

(101 citation statements)

References 32 publications

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“…This phenomenon could have influenced our findings in the lower limbs and underestimated true differences in perfusion between groups. However, in the study by Christian et al (32), underestimation of flow was most problematic at peak flow rates greater than 200 -250 mL/ miniute/100 g tissue, peak values at the upper limit of that typically reported in the limbs of normal controls (14,29,33,34) and well below that described in PAD (20).…”

Section: Limitationsmentioning

confidence: 85%

“…In each of these MR studies, predominantly healthy volunteers were evaluated during reactive hyperemia and test characteristics were not assessed under low-flow conditions like that anticipated in patients with significant arterial insufficiency. Of the published techniques, those employing arterial spin labeling (25,29) and gadolinium first-pass enhancement appear most promising (13,14).…”

Section: Discussionmentioning

confidence: 99%

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Calf muscle perfusion at peak exercise in peripheral arterial disease: Measurement by first‐pass contrast‐enhanced magnetic resonance imaging

Isbell

Epstein

Zhong

et al. 2007

Magnetic Resonance Imaging

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Purpose:To develop a contrast-enhanced magnetic resonance (MR) technique to measure skeletal muscle perfusion in peripheral arterial disease (PAD). Materials and Methods:A total of 11 patients (age ϭ 61 Ϯ 11 years) with mild to moderate symptomatic PAD (anklebrachial index [ABI] ϭ 0.75 Ϯ 0.08) and 22 normals were studied using an MR-compatible ergometer. PAD and normal max (Nl max ; N ϭ 11) exercised to exhaustion. Nl low (N ϭ 11) exercised to the same workload achieved by PAD. At peak exercise, 0.1 mm/kg of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) was infused at 3-4 cm 3 / second followed by a saline flush at the same rate. A dualcontrast gradient echo (GRE) sequence enabled simultaneous acquisition of muscle perfusion and arterial input function (AIF). The perfusion index (PI) was defined as the slope of the time-intensity curve (TIC) in muscle divided by the arterial TIC slope. Results Conclusion:Peak-exercise measurement of lower limb perfusion with dual-contrast, first-pass MR distinguishes PAD from normals. This method may be useful in the study of novel therapies for PAD.

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Section: Limitationsmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Calf muscle perfusion at peak exercise in peripheral arterial disease: Measurement by first‐pass contrast‐enhanced magnetic resonance imaging

Isbell

Epstein

Zhong

et al. 2007

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…For that reason, considerable efforts have been made in recent years to develop robust MRI procedures for the measurement of the local microvascular perfusion of muscle. Two main MRI techniques from which information on perfusion can be obtained should be distinguished: (a) arterial spin labeling (ASL), which makes use of the dynamic magnetic labeling of flowing arterial water to distinguish it from non-flowing tissue water (190)(191)(192); (b) dynamic contrast MRI techniques, which rely on the transient signal change that is caused by the entry of intravenously injected MRI contrast agent in the target tissue (193,194). The detection of the contrast agent can either be based on T 1 shortening with T 1 -weighted MRI (e.g.…”

Section: Mri Of Muscle Perfusion and Oxygenationmentioning

confidence: 99%

“…In principle, the ASL method is to be preferred, since it makes use of endogenous water to achieve perfusionbased image contrast and does not require the invasive injection of contrast agent. ASL is able to produce quantitative numbers on tissue perfusion by subtracting an image acquired with blood preparation from an image without magnetic labeling of the blood component, combined with modeling using the extended Bloch equations (190)(191)(192). The fundamental drawback of ASL, however, is that it is relatively insensitive and therefore has considerable difficulty in quantifying low perfusion values, such as those occurring in resting skeletal muscle.…”

Section: Mri Of Muscle Perfusion and Oxygenationmentioning

confidence: 99%

Dynamic MRS and MRI of skeletal muscle function and biomechanics

et al. 2006

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MR is a powerful technique for studying the biomechanical and functional properties of skeletal muscle in vivo in health and disease. This review focuses on 31 P, 1 H and 13 C MR spectroscopy for assessment of the dynamics of muscle metabolism and on dynamic 1 H MRI methods for non-invasive measurement of the biomechanical and functional properties of skeletal muscle. The information thus obtained ranges from the microscopic level of the metabolism of the myocyte to the macroscopic level of the contractile function of muscle complexes. The MR technology presented plays a vital role in achieving a better understanding of many basic aspects of muscle function, including the regulation of mitochondrial activity and the intricate interplay between muscle fiber organization and contractile function. In addition, these tools are increasingly being employed to establish novel diagnostic procedures as well as to monitor the effects of therapeutic and lifestyle interventions for muscle disorders that have an increasing impact in modern society.

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“…The T2* difference map (Fig. 2) is markedly different from perfusion maps obtained with arterial spin labeling or contrast enhancement techniques (23), which suggests that the change of fluid level in the calf was more likely associated with mechanisms related to postural change. The T2* difference maps demonstrate the heterogeneous character of the T2* changes over the lower-leg cross section (Fig.…”

Section: Discussionmentioning

confidence: 86%

Proton and sodium MRI assessment of fluid level in calf tissue

Chen

Villafuerte

Henry

et al. 2006

Magnetic Resonance Imaging

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Purpose:To investigate the feasibility of using 1 H and 23 Na MRI to detect fluid levels in the lower leg muscle. Materials and Methods:Proton and sodium MRI was applied to detect body fluid levels in the lower leg muscles of 18 healthy young male subjects at 3T and 4T. The paradigms under investigation were a postural change from sitting upright to lying supine, and saline infusion. Results:We found that the average proton MR signal in gastrocnemius and soleus muscles were reduced following the postural change by 3.5% Ϯ 1.4% (P Ͻ 0.05) and rose following saline infusion by 3.7% Ϯ 0.9% (P Ͻ 0.01). More dramatically, the sodium MR signal decreased by 7.1% Ϯ 1.2% (P Ͻ 0.01) following the postural change and increased following saline infusion by 12% Ϯ 3.8% (P Ͻ 0.05). The ratio of intra-to extracellular fluid levels was 1.6 Ϯ 0.5 for the subjects based on the acquired proton and sodium data. Conclusion:Our results indicate that proton and sodium MRI can be used to assess fluid levels in the lower extremities, and this technique may be applied to evaluate fluid retention.

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Dynamic imaging of perfusion in human skeletal muscle during exercise with arterial spin labeling

Cited by 104 publications

References 32 publications

Calf muscle perfusion at peak exercise in peripheral arterial disease: Measurement by first‐pass contrast‐enhanced magnetic resonance imaging

Calf muscle perfusion at peak exercise in peripheral arterial disease: Measurement by first‐pass contrast‐enhanced magnetic resonance imaging

Dynamic MRS and MRI of skeletal muscle function and biomechanics

Proton and sodium MRI assessment of fluid level in calf tissue

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