Calf muscle perfusion at peak exercise in peripheral arterial disease: Measurement by first‐pass contrast‐enhanced magnetic resonance imaging

Isbell, David C.; Epstein, Frederick H.; Zhong, Xiaodong; DiMaria, Joseph M; Berr, Stuart S.; Meyer, Craig H.; Rogers, W. Todd; Harthun, Nancy L.; Hagspiel, Klaus D.; Weltman, Arthur; Kramer, Christopher M.

doi:10.1002/jmri.20899

Cited by 76 publications

(70 citation statements)

References 41 publications

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“…26 Meanwhile, the exercise of the muscular tissues was accompanied by heat production 27 and the increasing of local blood perfusion. 28 Both will promote the water diffusion in vivo. The slight increase of l 1 probably suggests that the promotion of water diffusion caused by heat production and the increase of local blood perfusion may exceed the hindrance caused by muscle shortening.…”

Section: Discussionmentioning

confidence: 99%

In vivomorphological and functional evaluation of the lateral pterygoid muscle: a diffusion tensor imaging study

Liu¹,

Wang²,

Ai³

et al. 2016

BJR

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Objective: To explore the feasibility of morphological and functional evaluation of the lateral pterygoid muscle (LPM) by diffusion tensor imaging (DTI) in vivo. Methods: 30 healthy volunteers underwent DTI with the jaw in the rest position, opening and clenching. Diffusion parameters of the superior head of the LPM (SHLP) and the inferior head of the LPM (IHLP) at different jaw positions were calculated. Results: When the jaw was in the rest position, l 3 of the SHLP was significantly lower than that of the IHLP; fractional anisotropy (FA) value of the SHLP was significant higher than that of the IHLP. There was no significant difference in l 1 , l 2 and apparent diffusion coefficient (ADC) value. During jaw opening, there was significant increase of all three eigenvalues and ADC value, and significant decrease of FA value both at the SHLP and IHLP. Clenching caused a significant increase in the ADC and all three eigenvalues, and caused a significant decrease of FA at the SHLP. However, at the IHLP, the variations of all diffusion parameters by clenching in the intercuspal position showed no significance when compared with those at rest. Conclusion: The morphological and functional changes of LPM fibres caused by jaw movements could be sensitively detected by DTI which may serve as a new and noninvasive method for simultaneously investigating the functional and morphological features of the LPM during jaw movement. Advances in knowledge: A new application of DTI is proposed for the morphological and functional evaluation of the LPMs. The results show that the significant change of three eigenvalues indicates the activity of the LPM in a specific jaw movement, a finding that shows the potential value of DTI serving as a new and non-invasive method for investigation of the LPM.

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Section: Discussionmentioning

confidence: 99%

In vivomorphological and functional evaluation of the lateral pterygoid muscle: a diffusion tensor imaging study

Liu¹,

Wang²,

Ai³

et al. 2016

BJR

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“…The molecular size-dependent basal vascular permeability rates used in this PAD model were the same as those used in the healthy model (81) (Table S. 2). In light of evidence suggestive of decreased muscle perfusion in PAD patients, including measurements of decreased red blood cell velocity (17), increased time to peak intensity of bolus-injected ultrasound contrast agents (19), decreased calf muscle perfusion at peak exercise (35), decreased skin perfusion pressure (68), and increased percentage of no-flow capillaries (9), we assume the effective vascular permeability rate for the PAD calf at control (supine position) to be at 50% of healthy basal level by adjusting the endothelial surface area recruitment factor to ␥ ϭ 0.5 (Table 3). However, the loss of the venoarterial reflex (VAR) had been documented in PAD patients, such that the lower-than-normal perfusion of the supine foot about doubled (i.e., increased, rather than decreased as should happen with a normal VAR) to a higher-than-normal perfusion in the dependent position (14).…”

Section: Model Parameterization For a Sedentary Pad Patientmentioning

confidence: 99%

VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model

Stefanini

Gabhann

et al. 2010

American Journal of Physiology-Heart and Circulatory Physiology

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Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis, the growth of new capillaries from existing microvasculature. In peripheral arterial disease (PAD), lower extremity muscle ischemia develops downstream of atherosclerotic obstruction. A working hypothesis proposed that the maladaptive overexpression of soluble VEGF receptor 1 (sVEGFR1) in ischemic muscle tissues, and its subsequent antagonism of VEGF bioactivity, may contribute to the deficient angiogenic response in PAD, as well as the limited success of therapeutic angiogenesis strategies where exogenous VEGF genes/proteins are delivered. The objectives of this study were to develop a computational framework for simulating the systemic distributions of VEGF and sVEGFR1 (e.g., intramuscular vs. circulating, free vs. complexed) as observed in human PAD patients and to serve as a platform for the systematic optimization of diagnostic tools and therapeutic strategies. A three-compartment model was constructed, dividing the human body into the ischemic calf muscle, blood, and the rest of the body, connected through macromolecular biotransport processes. Detailed molecular interactions between VEGF, sVEGFR1, endothelial surface receptors (VEGFR1, VEGFR2, NRP1), and interstitial matrix sites were modeled. Our simulation results did not support a simultaneous decrease in plasma sVEGFR1 during PAD-associated elevations in plasma VEGF reported in literature. Furthermore, despite the overexpression in sVEGFR1, our PAD control demonstrated increased proangiogenic signaling complex formation, relative to our previous healthy control, due to sizeable upregulations in VEGFR2 and VEGF expression, thus leaving open the possibility that impaired angiogenesis in PAD may be rooted in signaling pathway disruptions downstream of ligand-receptor binding.

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“…13 Our group has performed a series of studies to validate and assess the potential use of these measures in PAD. [14][15][16] …”

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confidence: 99%

Peripheral Arterial Disease Assessment

Kramer

2007

Topics in Magnetic Resonance Imaging

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Calf muscle perfusion at peak exercise in peripheral arterial disease: Measurement by first‐pass contrast‐enhanced magnetic resonance imaging

Cited by 76 publications

References 41 publications

In vivomorphological and functional evaluation of the lateral pterygoid muscle: a diffusion tensor imaging study

In vivomorphological and functional evaluation of the lateral pterygoid muscle: a diffusion tensor imaging study

VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model

Peripheral Arterial Disease Assessment

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