Dynamic High-Resolution Ultrasound In Vivo Imaging of Hyaluronic Acid Filler Injection

Abstract

High-resolution ultrasound allows in vivo study of HA injection behavior. HA adopts different morphology within the tissue depending on the density and compliance of the tissues in the plane of injection.

Ultrasound to improve the safety of hyaluronic acid filler treatments

“…All hyaluronic acid fillers are able to bind water and are thus hydrophilic. As water content does not reflect the sound waves, hyaluronic acid appears black (an echogenic) or light gray hypoechoic) on ultrasound Figure . The ubiquitously used hyaluronic acid fillers come in different particle sizes, meant for different applications, and are placed in different layers of the skin and subdermis.…”

High frequency ultrasound with color Doppler in dermatology

“…In the dermis, there is an increase in echogenicity as subdermal injections produce multiple anechoic pearls. 63 De Pasquale et al observed that, in the subcutaneous tissue, hyaluronic acid is perceived as a regular, well defined, hypoechoic mass. 64 As different fillers have their own characteristics to HFUS, this may also be useful to differentiate their nature so as to detect possible complications.…”

Ultrasound and Histologic Examination after Subcutaneous Injection of Two Volumizing Hyaluronic Acid Fillers: A Preliminary Study

“…The data complement findings from previous research that has used ultrasound imaging and histologic examination to determine the behavior of HA gels after injection into the different dermal layers. 7−9,17 These studies have shown that the tissue distribution and morphology of HA gels is significantly affected by their respective crosslinking technology. Further studies are now warranted to examine the tissue behavior of CPM volumizing gel with lidocaine, which was not available at the time the current study was performed.…”