“…Intra-and interchromosomal interactions (Gerasimova et al, 2000;Lanctot et al, 2007;Simonis et al, 2006;Xu et al, 2004), mediated by macromolecular complexes comprising proteins and nucleic acids, provide one mechanism by which the genome could be spatially arranged into functional subcompartments. This potential is exemplified by the fact that the interacting DNA sequences are often not linearly arranged or even on the same chromosome (Dostie et al, 2006;Ling et al, 2006;O'Sullivan et al, 2004;Simonis et al, 2006;Spilianakis et al, 2005;Zhao et al, 2006).…”