Dynamic functional hippocampal markers of residual depressive symptoms in euthymic bipolar disorder

Saccaro, Luigi Francesco; Gaviria, Julian; Ville, Dimitri Van De; Piguet, Camille

doi:10.31234/osf.io/9d76z

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…One hypothesis is that sensory processing, or how a sensory stimulus is perceived and assigned importance or saliency, may underlie ED as a component of the ER process (269). A decrease in SMN-associated FC is documented in depressed BD patients (270,271), and inflammation may also play a role during depressive episodes. Indeed, proinflammatory interleukins (IL-6, 8) have been associated with hypoactive SMN in depressed BD patients (on both pre-and postcentral gyri) (222,257).…”

Section: Inflammatory Correlates Of Behavioural and Neurobiological M...mentioning

confidence: 99%

Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

Petruso¹,

Giff²,

Milano³

et al. 2023

Preprint

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Emotion dysregulation (ED) describes a difficulty with the modulation of which emotions are felt, as well as when and how these emotions are experienced or expressed. It is a focal overarching symptom in many severe and prevalent neuropsychiatric diseases, including bipolar disorders (BD), attention deficit and hyperactivity disorder (ADHD), and borderline personality disorder (BPD). In all these disorders, ED can manifest through symptoms of depression, anxiety, or affective lability. Considering the many similarities in symptoms between BD, ADHD, and BPD, a transdiagnostic approach is a promising lens of investigation. Mounting evidence supports the role of peripheral inflammatory markers and stress in the multifactorial aetiology and physiopathology of BD, ADHD, and BPD. Of note, neural circuits that regulate emotions appear particularly vulnerable to inflammatory insults and peripheral inflammation, which can impact the neuroimmune milieu of the central nervous system. Thus far, few studies have examined the link between ED and inflammation in BD, ADHD, and BPD. To our knowledge, no specific work has provided a critical comparison of the results from these disorders. To fill this gap in the literature, we review the known associations and mechanisms linking ED and inflammation in general, and clinically, in BD, ADHD, and BD. Our narrative review begins with an examination of the routes linking ED and inflammation, followed by a discussion of disorder-specific results accounting for methodological limitations and relevant confounding factors. Finally, we critically discuss both correspondences and discrepancies in the results and comment on potential vulnerability markers and promising therapeutic interventions.

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Section: Inflammatory Correlates Of Behavioural and Neurobiological M...mentioning

confidence: 99%

Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

Petruso¹,

Giff²,

Milano³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The concept of CAP is to categorize temporal frames with similar spatial co‐activation profiles into distinct CAP states through clustering. An expanding body of research has applied CAP analysis to elucidate neurological and psychological disorders (Ma et al., 2020; Saccaro et al., 2023; Yang et al., 2021). Nevertheless, no study has yet employed a time‐frame‐based approach to uncover the dynamics of brain networks in PD.…”

Section: Introductionmentioning

confidence: 99%

The influence of accelerated brain aging on coactivation pattern dynamics in Parkinson's disease

Yan,

Lu,

Zhu

et al. 2024

J of Neuroscience Research

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Aging is widely acknowledged as the primary risk factor for brain degeneration, with Parkinson's disease (PD) tending to follow accelerated aging trajectories. We aim to investigate the impact of structural brain aging on the temporal dynamics of a large‐scale functional network in PD. We enrolled 62 PD patients and 32 healthy controls (HCs). The level of brain aging was determined by calculating global and local brain age gap estimates (G‐brainAGE and L‐brainAGE) from structural images. The neural network activity of the whole brain was captured by identifying coactivation patterns (CAPs) from resting‐state functional images. Intergroup differences were assessed using the general linear model. Subsequently, a spatial correlation analysis between the L‐brainAGE difference map and CAPs was conducted to uncover the anatomical underpinnings of functional alterations. Compared to HCs (−3.73 years), G‐brainAGE was significantly higher in PD patients (+1.93 years), who also exhibited widespread elevation in L‐brainAGE. G‐brainAGE was correlated with disease severity and duration. PD patients spent less time in CAPs involving activated default mode and the fronto‐parietal network (DMN‐FPN), as well as the sensorimotor and salience network (SMN‐SN), and had a reduced transition frequency from other CAPs to the DMN‐FPN and SMN‐SN CAPs. Furthermore, the pattern of localized brain age acceleration showed spatial similarities with the SMN‐SN CAP. Accelerated structural brain aging in PD adversely affects brain function, manifesting as dysregulated brain network dynamics. These findings provide insights into the neuropathological mechanisms underlying neurodegenerative diseases and imply the possibility of interventions for modifying PD progression by slowing the brain aging process.

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Emotional Regulation Underlies Gender Differences in Pathological Eating Behavior Styles of Bariatric Surgery Candidates

Saccaro

Rutigliano

Landi

et al. 2023

Women

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Almost a third of bariatric surgery patients present suboptimal weight loss or important weight regain in the first five postoperative years. While the reasons underlying this are not fully understood, it is known that pathological eating styles (such as emotional or binge eating) can thwart efforts to maintain weight loss. However, detailed characterization and understanding of these eating styles have yet to be achieved. In particular, research on gender differences in pathological eating styles and psychiatric symptoms before bariatric surgery is lacking. To characterize gender differences in eating styles and their association with clinical symptoms, we prospectively enrolled 110 bariatric surgery candidates, collecting eating styles and clinical scores. Women displayed a higher frequency of emotional eating as compared to men (x2 = 9.07, p = 0.003), while men showed a higher frequency of quantitative eating behavioral style (x2 = 4.58, p = 0.044). Binge eating style was associated with higher Difficulties in Emotion Regulation Scale (DERS), Hamilton Depression Scale (HAM-D), and Hamilton Anxiety Scale (HAM-A) scores (p < 0.05). Emotional eating style was associated with higher HAM-D and HAM-A scores (p < 0.05). The present findings highlight the importance of understanding the role of gender differences in emotion regulation processes involved in the development and maintenance of pathological eating styles in bariatric surgery candidates. This paves the way to gender- and symptoms-specific interventions on eating behaviors to improve surgery long-term outcomes.

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Dynamic functional hippocampal markers of residual depressive symptoms in euthymic bipolar disorder

Cited by 3 publications

References 40 publications

Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

The influence of accelerated brain aging on coactivation pattern dynamics in Parkinson's disease

Emotional Regulation Underlies Gender Differences in Pathological Eating Behavior Styles of Bariatric Surgery Candidates

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