The influence of accelerated brain aging on coactivation pattern dynamics in Parkinson's disease
Su Yan,
Jun Lu,
Hongquan Zhu
et al.
Abstract:Aging is widely acknowledged as the primary risk factor for brain degeneration, with Parkinson's disease (PD) tending to follow accelerated aging trajectories. We aim to investigate the impact of structural brain aging on the temporal dynamics of a large‐scale functional network in PD. We enrolled 62 PD patients and 32 healthy controls (HCs). The level of brain aging was determined by calculating global and local brain age gap estimates (G‐brainAGE and L‐brainAGE) from structural images. The neural network act… Show more
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