Dynamic evolution of V1R putative pheromone receptors between Mus musculus and Mus spretus

Kurzweil, Vanessa; Getman, Mike; Green, Eric D.; Lane, Robert P.

doi:10.1186/1471-2164-10-74

Cited by 26 publications

(22 citation statements)

References 29 publications

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“…Zhang et al (2007) compared the gene repertoires between V1Rs and olfactory receptor genes (ORs) in mice and rats, showing that V1Rs evolved more rapidly than ORs in a species-specific manner. Moreover, Kurzweil et al (2009) and Karn et al (2010) revealed differences in V1Rs in closely related mouse species and subspecies, respectively. These lines of evidence suggest that V1Rs contribute to the speciation and diversification of mammals.…”

Section: Highly Diverse V1r Repertoires In Mammalsmentioning

confidence: 98%

Evolution of <i>V1R</i> pheromone receptor genes in vertebrates: diversity and commonality

Nikaido

2019

Genes Genet. Syst.

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The vomeronasal organ (VNO) plays a key role in sensing pheromonal cues, which elicit innate responses and induce social and sexual behaviors. The vomeronasal receptor 1 genes, V1Rs, encode members of a pheromone receptor family that are mainly expressed in the VNO. Previous studies have revealed that the V1R family shows extraordinary variety among mammalian species owing to successive gene gains and losses. Because species-specific pheromonal interaction may facilitate species-specific reproductive behaviors, understanding the evolution of V1Rs in terms of their origin, repertoire and phylogeny should provide insight into the mechanisms of animal diversification. Here I summarize recent studies about the V1R family from its initial discovery in the rat genome to extensive comparative analyses among vertebrates. I further introduce our recent findings for V1Rs in a broad range of vertebrates, which reveal unexpected diversity as well as shared features common among lineages.

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Section: Highly Diverse V1r Repertoires In Mammalsmentioning

confidence: 98%

Evolution of <i>V1R</i> pheromone receptor genes in vertebrates: diversity and commonality

Nikaido

2019

Genes Genet. Syst.

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“…Recently Kurzweil et al reported the sequencing of a cluster of V1R genes and pseudogenes from a SPRET/EiJ BAC library [33]. We identified nine BAC sequenced V1R genes (8.1 kb of sequence) that was also in our parsed dataset.…”

Section: Resultsmentioning

confidence: 94%

Genomic variation in the vomeronasal receptor gene repertoires of inbred mice

et al. 2012

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BackgroundVomeronasal receptors (VRs), expressed in sensory neurons of the vomeronasal organ, are thought to bind pheromones and mediate innate behaviours. The mouse reference genome has over 360 functional VRs arranged in highly homologous clusters, but the vast majority are of unknown function. Differences in these receptors within and between closely related species of mice are likely to underpin a range of behavioural responses. To investigate these differences, we interrogated the VR gene repertoire from 17 inbred strains of mice using massively parallel sequencing.ResultsApproximately half of the 6222 VR genes that we investigated could be successfully resolved, and those that were unambiguously mapped resulted in an extremely accurate dataset. Collectively VRs have over twice the coding sequence variation of the genome average; but we identify striking non-random distribution of these variants within and between genes, clusters, clades and functional classes of VRs. We show that functional VR gene repertoires differ considerably between different Mus subspecies and species, suggesting these receptors may play a role in mediating behavioural adaptations. Finally, we provide evidence that widely-used, highly inbred laboratory-derived strains have a greatly reduced, but not entirely redundant capacity for differential pheromone-mediated behaviours.ConclusionsTogether our results suggest that the unusually variable VR repertoires of mice have a significant role in encoding differences in olfactory-mediated responses and behaviours. Our dataset has expanded over nine fold the known number of mouse VR alleles, and will enable mechanistic analyses into the genetics of innate behavioural differences in mice.

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“…Prior research has generated controversy over what evolutionary forces mediate V1R evolution. Some studies detect evidence of positive selection and lineage-specific pseudogenization, while another study finds evidence for genetic drift and negative selection (Emes et al, 2004; Kurzweil et al, 2009; Park et al, 2011). Our data suggest that these seemingly contradictory results are not mutually exclusive.…”

Section: Discussionmentioning

confidence: 99%

Distinct evolutionary trajectories of V1R clades across mouse species

Miller

Sheehan

Campbell

2019

Preprint

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29Background: Many animals rely heavily on olfaction to navigate their environment. Among rodents, 30 olfaction is crucial for a wide range of social behaviors. The vomeronasal olfactory system in particular 31 plays an important role in mediating social communication, including the detection of pheromones and 32 recognition signals. Currently, very few vomeronasal receptors have known ligands, which severely limits 33 our understanding of chemosensory-driven social communication. In this study we examine patterns of 34 vomeronasal type-1 receptor (V1R) evolution in the house mouse and related species within the genus 35 Mus. By exploring the evolution of these receptors, we provide insight into the functional roles of receptor 36 subtypes as well as the dynamics of gene family evolution. 37Results: We generated transcriptomes from the vomeronasal organs of 5 Mus species, and produced 38 high quality V1R repertoires for each species. We find that V1R clades in the house mouse and relatives 39 exhibit distinct evolutionary trajectories. Some clades are highly conserved, while others reveal patterns 40 of rapid evolutionary change. We identify putative species-specific gene expansions, including a dramatic 41 clade D expansion in the house mouse. While gene gains are abundant, we detect very few gene losses. 42We describe a novel V1R clade and highlight candidate receptors for future de-orphanization. Based on 43 clade-level evolutionary patterns, we identify receptor families that are strong candidates for detecting 44 social signals and predator cues. Our results further support the view that V1Rs are important for 45 detecting the physiological status of conspecifics, particularly female estrus cues. 46Conclusion: Analysis of clade-level evolution is critical for understanding species' chemosensory 47 adaptations. This study provides clear evidence that V1R clades are characterized by distinct 48 evolutionary trajectories. As receptor evolution is shaped by ligand identity, these results provide a

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Dynamic evolution of V1R putative pheromone receptors between Mus musculus and Mus spretus

Cited by 26 publications

References 29 publications

Evolution of <i>V1R</i> pheromone receptor genes in vertebrates: diversity and commonality

Evolution of <i>V1R</i> pheromone receptor genes in vertebrates: diversity and commonality

Genomic variation in the vomeronasal receptor gene repertoires of inbred mice

Distinct evolutionary trajectories of V1R clades across mouse species

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