Dynamic covalent hydrazine chemistry as a selective extraction and cleanup technique for the quantification of the Fusarium mycotoxin zearalenone in edible oils

Siegel, David J.; Andrae, K.; Proske, M.; Kochan, Cindy; Koch, Matthias; Weber, Marcus; Nehls, Irene

doi:10.1016/j.chroma.2010.02.019

Cited by 28 publications

(23 citation statements)

References 41 publications

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“…Therefore, endeavours are made for the development of molecular imprinted materials that combine ruggedness of conventional solid phase extraction columns with a better selectivity (Urraca et al, 2006;Choi et al, 2009;Lucci et al, 2010). Besides this, experimental bead-based extraction is under study, possibly offering alternatives in the future (Hervas et al, 2009;Siegel et al, 2010).…”

Section: Sample Preparationmentioning

confidence: 99%

Scientific Opinion on the risks for public health related to the presence of zearalenone in food

2011

EFSA Journal

346

142

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Zearalenone is a mycotoxin produced by several Fusarium species. It is commonly found in maize but can be found also in other crops such as wheat, barley, sorghum and rye. The European Commission asked the European Food Safety Authority to review the safety of zearalenone and the risk to consumers of a possible increase of the maximum level (ML) for zearalenone in breakfast cereals. A total of 13,075 analytical results obtained on food samples and 9,877 results on unprocessed grains sampled by 19 European countries in 2005-2010 were used in the evaluation. The highest concentrations of zearalenone were reported for wheat bran, corn and products thereof (e.g. corn flour, cornflakes). Grains and grain-based foods, in particular grains and grain milling products, bread and fine bakery wares, made the largest contribution to the estimated zearalenone exposures. Vegetable oils also made an important contribution to the zearalenone exposure. The critical effects of zearalenone result from its oestrogenic activity. Based on recent data in the most sensitive animal species, the pig, and taking into account comparisons between pigs and humans, the Panel on Contaminants in the Food Chain established a tolerable daily intake (TDI) for zearalenone of 0.25 μg/kg b.w. Estimates of chronic dietary exposure to zearalenone based on the available occurrence data are below or in the region of the TDI for all age groups and not a health concern. A potential increase in the ML for zearalenone in breakfast cereals from 50 µg/kg to 75, 100, 125 or 150 µg/kg is unlikely to result in a chronic dietary exposure exceeding the TDI. In a worst case scenario it is possible that an individual could consume the same batch of breakfast cereal containing zearalenone at the ML every day for 2 to 4 weeks, in which case exposures may exceed the TDI.

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Section: Sample Preparationmentioning

confidence: 99%

Scientific Opinion on the risks for public health related to the presence of zearalenone in food

2011

EFSA Journal

346

142

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“…The LOD was 10 μg/kg, and the recoveries were in the range of 87.0–91.0%. Siegel et al reported the determination of ZON by dynamic covalent hydrazine chemistry (DCHC) with HPLC‐FLD. Specifity and precision of this approach are superior to LLE or GPC purification methods.…”

Section: Mycotoxinsmentioning

confidence: 99%

Analytical approaches for measuring pesticides, mycotoxins and heavy metals in vegetable oils: A review

et al. 2015

Euro J Lipid Sci & Tech

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Nowadays, consumers are concerned about the toxicological implications and in a great demand for more information about the presence of organic residues and contaminants in vegetable oils. Pesticide residues, mycotoxins, and heavy metals can be readily accumulated in vegetable oil during the cultivation, processing and storage. Those chemical contaminants or its metabolites are carcinogenic, teratogenic, and immunotoxic, which result in serious damages to human health. With public health and economic losses considered, many analytical methods have been reported for the determination of chemical contaminants in vegetable oils. The aim of this review is to provide an update on the historical and current methods for the determination of contaminants in oil samples, discuss and evaluate the features, advantages and limitations, and finally outline the prospects for the multi‐class chemical contaminants determination in vegetable oils. Practical applications: Different strategies and advantages of analytical methods for determination of chemical contaminants in vegetable oils are discussed and evaluated. The features and the prospects are useful for the development of the multi‐class methodology in lipid matrix. Vegetable oils are widely used for cooking and processing in the food industry, meeting dietary demands. Major chemical contaminants, such as pesticide residues, mycotoxins, and heavy metals, are commonly found in vegetable oils. In this review, we provide an update on the historical and current methods for the determination of contaminants in oil samples, discuss and evaluate different analytical methods and techniques, and finally outline the prospects for the determination of major chemical contaminants in vegetable oils.

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“…Ein neues Probenvorbereitungsverfahren haben Siegel et al an der Bundesanstalt für Materialprüfung‐ und ‐forschung, BAM, entwickelt und in der Ausführung als Batch‐Technik veröffentlicht 7…”

Section: Ein Neuer Lösungsansatz: Chemiesorptionunclassified

“…Um den Analyten freizusetzen, wird die Hydrazonbindung hydrolysiert und so der chemisch unveränderte Analyt zurückgewonnen (Abbildung 1). Die Literatur benennt dieses Verfahren als dynamisch kovalente Hydrazinchemie (DCHC) 7…”

Section: Ein Neuer Lösungsansatz: Chemiesorptionunclassified

Unpolarer Analyt, unpolare Matrix: das Mykotoxin Zearalenon in Öl

Weiz¹,

Marten²,

Heinze³

et al. 2013

Nachr Chem

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Dynamic covalent hydrazine chemistry as a selective extraction and cleanup technique for the quantification of the Fusarium mycotoxin zearalenone in edible oils

Cited by 28 publications

References 41 publications

Scientific Opinion on the risks for public health related to the presence of zearalenone in food

Scientific Opinion on the risks for public health related to the presence of zearalenone in food

Analytical approaches for measuring pesticides, mycotoxins and heavy metals in vegetable oils: A review

Unpolarer Analyt, unpolare Matrix: das Mykotoxin Zearalenon in Öl

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