Dynamic Changes in the Tear Film in Dry Eyes

Montés‐Micó, Robert; Alió, Jorge L.; Charman, W. N.

doi:10.1167/iovs.05-0017

Cited by 156 publications

(127 citation statements)

References 17 publications

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“…[6][7][8] In other studies, the changes of higher order ocular surface wavefront aberrations were investigated in normal and dry eyes. 3,9 The higher order aberrations were found to first decrease immediately after a blink, reaching a minimum 6 s post-blink, and then to increase steadily. 3 Nemeth et al 2 used high-speed videokeratoscopy to assess tear film regularity changes at a sampling frequency of 4 Hz.…”

Section: Introductionmentioning

confidence: 97%

Dynamics of ocular surface topography

Zhu

Collins

Iskander

2006

Eye

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Purpose To investigate fluctuations in the ocular surface, we used high-speed videokeratoscopy (50 Hz) to measure the dynamics of the ocular surface topography. Methods Ocular surface height difference maps were computed to illustrate the changes in the tear film in the inter-blink interval. Topography data were used to derive the ocular surface wavefront aberrations up to the fourth radial order of the Zernike polynomial expansion. We examined the ocular surface dynamics and temporal changes in the ocular surface wavefront aberrations in the inter-blink interval. Results During the first 0.5 s following a blink, the ocular surface height at the upper edge of the topography map increased by about 2 lm. Temporal changes occurred for some ocular surface wavefront aberrations and appeared to be related to changes in the distribution of tear film. Conclusion In the clinical measurement of ocular surface topography using videokeratoscopy or optics of the eye using wavefront sensors, care should be taken to avoid the initial tear film build-up phase following a blink to achieve more consistent results.

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Section: Introductionmentioning

confidence: 97%

Dynamics of ocular surface topography

Zhu

Collins

Iskander

2006

Eye

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“…Several studies have been devoted to understanding the dynamics of ocular aberrations, as well as their origin. Fixational eye movements [6,7], tear film dynamics [8][9][10] and micro-fluctuations of accommodation [11,12] were identified as important sources of temporal variation of ocular aberration. However, the relative contribution of each of these elements remains unknown or incompletely known, especially concerning fixational eye movements, i.e.continuous and involuntary movements while the subject is looking at a fixation target.…”

Section: Introductionmentioning

confidence: 99%

Fixational eye movement: a negligible source of dynamic aberration

Mecê¹,

Jarosz²,

Conan³

et al. 2018

Biomed. Opt. Express

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“…Several studies have investigated the influence of tear film dynamics on sequential wavefront aberrations in dry eyes and normal eyes. 26,31,32 Nowadays, wavefront sensing has been recognized as a practical objective method for evaluating sequential changes in optical quality of the eye. Thus, in the present study, we examined the sequential changes in ocular aberrations with the wavefront aberrometer to comprehend the detailed influence of eye ointment on ocular optical quality.…”

Section: Discussionmentioning

confidence: 99%

Time course of changes in ocular wavefront aberration after administration of eye ointment

Hiraoka

Yamamoto²,

Okamoto

et al. 2012

Eye

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Purpose To investigate the influence of an eye ointment on ocular aberration. Design Prospective, comparative study. Methods In 10 normal volunteers, ocular aberration was assessed before and 5, 30 min, 1, 2, 3, 6, and 12 h after administration of ofloxacin eye ointment. Ocular aberration was sequentially measured over a period of 10 s, and the root mean square (RMS) of the second-, third-, fourth-, and total higher-order aberrations (HOAs) were determined. From the sequential changes in total HOAs during 10 s, the fluctuation index (FI) and stability index (SI) were calculated. The obtained data were compared with those of another 17 normal volunteers who received timolol maleate gel-forming ophthalmic solution.Results No significant changes in secondorder RMS were observed after administration of the ointment. HOAs such as third-, fourth-, and total higher-order RMS significantly changed during the study period (Po0.05, repeated-measures analysis of variance). The RMS of each HOA component significantly increased 5 min after administration compared with the baseline values (Po0.05, Dunnett test). FI also increased significantly 5 min after administration (Po0.05), but SI did not change significantly. When compared with the results of the gel-forming solution group, HOAs and FI showed significantly higher values at several time points during 6 h after application (Po0.05, Mann-Whitney U-test). Conclusions Administration of eye ointment significantly degrades optical quality of the eye by increasing and oscillating HOAs. These changes were more pronounced than those after instillation of gel-forming ophthalmic solution for at least several hours.

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Dynamic Changes in the Tear Film in Dry Eyes

Cited by 156 publications

References 17 publications

Dynamics of ocular surface topography

Dynamics of ocular surface topography

Fixational eye movement: a negligible source of dynamic aberration

Time course of changes in ocular wavefront aberration after administration of eye ointment

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