Dynamic changes in fibrinogen and D-dimer levels in COVID-19 patients on nafamostat mesylate

Osawa, Itsuki; Okamoto, Koh; Ikeda, Mahoko; Otani, Amato; Wakimoto, Yuji; Yamashita, Marie; Shinohara, Takayuki; Kanno, Yoshihiro; Jubishi, Daisuke; Kurano, Makoto; Harada, Sohei; Okugawa, Shu; Yatomi, Yutaka; Moriya, Kyoji

doi:10.1007/s11239-020-02275-5

Cited by 20 publications

(15 citation statements)

References 28 publications

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“…Interestingly, we show no difference in D-Dimers between the two cohorts at admission [34]. This is in line with recent evidence suggesting dynamic changes in D-Dimers over the course of hospitalization to predict subsequent coagulopathy in COVID-19 patients [35].…”

Section: Discussionsupporting

confidence: 92%

Complement system component dysregulation is a distinctive feature of COVID-19 disease: a prospective and comparative analysis of patients admitted to the emergency department for suspected COVID-19 disease

Gauchel

Rieder

Krauel

et al. 2021

J Thromb Thrombolysis

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The complement system (CS) plays a pivotal role in Coronavirus disease 2019 (COVID-19) pathophysiology. The objective of this study was to provide a comparative, prospective data analysis of CS components in an all-comers cohort and COVID-19 patients. Patients with suspected COVID-19 infection admitted to the Emergency department were grouped for definite diagnosis of COVID-19 and no COVID-19 accordingly. Clinical presentation, routine laboratory and von Willebrand factor (vWF) antigen as well as CS components 3, 4 and activated 5 (C5a) were assessed. Also, total complement activity via the classical pathway (CH50) was determined. Levels of calprotectin in serum were measured using an automated quantitative lateral flow assay. We included 80 patients in this prospective trial. Of those 19 (23.7%) were tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with COVID-19 had higher levels of CS components 5a and 4 (54.79 [24.14–88.79] ng/ml vs. 35 [23.15–46.1] ng/ml; p = 0.0433 and 0.3772 [± 0.1056] g/L vs. 0.286 [0.2375–0.3748] g/L; p = 0.0168). COVID-19 patients had significantly higher levels of vWF antigen when compared to the control group (288.3 [± 80.26] % vs. 212 [151–320] %; p = 0.0469). There was a significant correlation between CS C3 and 5a with vWF antigen (rs = 0.5957 [p = 0.0131] and rs = 0.5015 [p = 0.042]) in COVID-19 patients. There was no difference in calprotectin plasma levels (4.786 [± 2.397] µg/ml vs. 4.233 [± 2.142] µg/ml; p = 0.4175) between both groups. This prospective data from a single centre all-comers cohort accentuates altered levels of CS components as a distinct feature of COVID-19 disease. Deregulation of CS component 3 and C5a are associated with increased vWF antigen possibly linking vascular damage to alternative CS activation in COVID-19.

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Section: Discussionsupporting

confidence: 92%

Complement system component dysregulation is a distinctive feature of COVID-19 disease: a prospective and comparative analysis of patients admitted to the emergency department for suspected COVID-19 disease

Gauchel

Rieder

Krauel

et al. 2021

J Thromb Thrombolysis

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“… 6 For example, a typical abnormality of COVID-19 disease is high levels of C-reactive protein (CRP) 7 and D-dimer. 8 Furthermore, serum procalcitonin (PCT) 9 and fibrinogen (Fg) 10 also have diagnostic value for patients with COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Predictors of COVID-19 Hospital Treatment Outcome

Tomasiuk¹,

Dąbrowski²,

Smykiewicz³

et al. 2021

IJGM

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Background There are more than 228,394,572 confirmed cases and 4,690,186 confirmed deaths caused by COVID-19 worldwide. The magnitude of the COOVID-19 pandemic has stimulated research on the treatment and diagnosis of COVID-19 patients. Objective In this report, a battery of specific parameters was used to develop a model that allows prediction of the outcome of the COVID-19 treatment. These parameters are C-reactive protein, procalcitonin, fibrinogen, D-dimers, immature granulocytes, and interleukin-6. Methods The study was carried out on a sample of N = 49 survivors (22 men, 27 women) and 83 deceased patients (62 men, 21 women). The distribution of means and differences in means of the parameters studied between survivors and deceased patients were evaluated using the bootstrap method. Results A mathematical model that allows for the prediction of hospitalization outcome was obtained using the Naive Bayes model. The results demonstrated a statistically significant difference between survivors and deceased patients in all parameters studied. A mathematical model employing a battery of parameters provided a 97% precision in predicting the outcome of hospitalization. Conclusion This study showed that the cross-correlation of survivability with absolute levels of C-reactive protein, procalcitonin, fibrinogen, D-dimers, immature granulocytes, and interleukin-6 could be used successfully in the hospital setting as a diagnostic tool.

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“…Osawa et al (22) revealed that COVID-19 infection is usually associated with coagulopathy resulting in elevated D-dimer levels. The increase in D-dimer levels during admission is associated with thromboembolic events.…”

Section: Discussionmentioning

confidence: 99%

Long-COVID neurological symptoms are associated with D-dimer levels in COVID-19 patients

et al. 2022

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Background Coronavirus disease 2019 (COVID-19) is a disease designated as a global pandemic by the WHO that can manifest clinically as neurological disorders that can occur in the acute phase or after the acute phase (long COVID-19), such as headache, myalgia, anosmia, and cognitive impairment. These neurological disorders as symptoms of long COVID-19 are presumably caused by hypercoagulable conditions characterized by an increase in D-dimer level. This study aims to determine the correlation of long COVID-19 neurological symptoms with hypercoagulable conditions and the role of D-dimer as a biomarker of long COVID-19 neurological symptoms. MethodsThis was a cross-sectional study involving 31 patients with long COVID-19 symptoms. Admitted long COVID-19 cases with recorded D-dimer levels and definitive outcomes were included consecutively. Long COVID-19 neurological symptoms were collected. D-dimer level was measured using immunofluorescence assay and reported in fibrinogen equivalent units (ìg/mL). The correlation between D-dimer levels and neurological clinical manifestations was assessed by using ordinal regression analysis. The p-value of <0.05 was considered statistically significant. ResultsThe mean age of the subjects was 38.81 ± 11.58 years and 18 (58.06%) were female. Long COVID neurological symptoms comprised myalgia, anosmia and cephalgia, and most subjects complained of myalgia (80.65%). On multivariable analysis, long-COVID-19 neurological symptoms were significantly correlated with D-dimer [odds ratio (OR) = 1.05; p=0.020]. ConclusionThe number of neurological long COVID symptoms were significantly correlated with level of D-Dimer. Ultimately, more clarity is needed on the neurological impact of COVID-19, its diagnosis, and its treatment.

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Dynamic changes in fibrinogen and D-dimer levels in COVID-19 patients on nafamostat mesylate

Cited by 20 publications

References 28 publications

Complement system component dysregulation is a distinctive feature of COVID-19 disease: a prospective and comparative analysis of patients admitted to the emergency department for suspected COVID-19 disease

Complement system component dysregulation is a distinctive feature of COVID-19 disease: a prospective and comparative analysis of patients admitted to the emergency department for suspected COVID-19 disease

Predictors of COVID-19 Hospital Treatment Outcome

Long-COVID neurological symptoms are associated with D-dimer levels in COVID-19 patients

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