Dynamic Changes in Brain Activity during Prism Adaptation

Luauté, Jacques; Schwartz, Sophie; Rossetti, Yves; Spiridon, Mona; Rode, Gilles; Boisson, Dominique; Vuilleumier, Patrik

doi:10.1523/jneurosci.3054-08.2009

Cited by 218 publications

(210 citation statements)

References 47 publications

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“…The neural correlates of sensorimotor adaptation have been investigated from various viewpoints, such as sensorimotor plasticity and motor learning. [17][18][19] Contrary to our expectations, most of these studies have proposed the importance of the cerebellum and the parietal cortex for sensorimotor adaptation. Too little has been reported on the involvement of the PFC.…”

Section: Introductioncontrasting

confidence: 85%

Role of the prefrontal cortex in the cognitive control of reaching movements: near-infrared spectroscopy study

Goto

Hoshi²,

Masashi

et al. 2011

J. Biomed. Opt.

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Abstract.To elucidate the role of the prefrontal cortex in cognitive control of reaching movements, by multichannel near-infrared spectroscopy we examine changes in oxygenated hemoglobin (oxy-Hb) as an indicator of changes in regional cerebral blood flow in the bilateral dorsolateral (DLPFC), ventrolateral prefrontal cortex (VLPFC), and frontopolar cortex (FPC) during a reaching task with normal visual feedback (a consistent task) and a reaching task with flipped horizontal visual feedback (an inconsistent task). Subjects first perform 12 trials of the consistent task, and then perform six blocks of the inconsistent task, each of which consists of six trials. During the consistent task, oxy-Hb is increased only in the right VLPFC. During the first block of the inconsistent task, increases in oxy-Hb are observed in the bilateral DLPFC and the right VLPFC, whereas the increased oxy-Hb was gradually reduced as the block proceeded, which was accompanied by an improvement in the task performance. Eventually, there were no differences in the degree of change in oxy-Hb between the consistent and inconsistent tasks in the DLPFC and VLPFC. These findings suggest that the DLPFC is engaged in higher order cognitive control, while the right VLPFC is engaged in both higher and lower order cognitive controls. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Section: Introductioncontrasting

confidence: 85%

Role of the prefrontal cortex in the cognitive control of reaching movements: near-infrared spectroscopy study

Goto

Hoshi²,

Masashi

et al. 2011

J. Biomed. Opt.

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“…These effects suggest rapid plasticity mechanisms and cerebral reorganisation in response to the visuo-motor mismatch. Interestingly, a recent fMRI study of prism adaptation in healthy participants (Luaute et al, 2009) reported that the magnitude of error produced by prismatic shift was correlated with activation of the ACC, consistent with the notion that this region plays crucial role in error detection (Kerns et al, 2004).…”

Section: Introductionsupporting

confidence: 56%

Parametric modulation of error-related ERP components by the magnitude of visuo-motor mismatch

Vocat¹,

Pourtois

Vuilleumier³

2011

Neuropsychologia

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a b s t r a c tErrors generate typical brain responses, characterized by two successive event-related potentials (ERP) following incorrect action: the error-related negativity (ERN) and the positivity error (Pe). However, it is unclear whether these error-related responses are sensitive to the magnitude of the error, or instead show all-or-none effects. We studied error-monitoring with ERPs while healthy adult participants performed ballistic pointing movements towards a visual target with or without optical prisms, in alternating runs. This allowed us to record variable pointing errors, ranging from slight to large deviations relative to the visual target. Behavioural results demonstrated a classic effect of prisms on pointing (i.e. initial shifts away from targets, with rapidly improving performance), as well as robust prismatic after-effects (i.e. deviations in the opposite direction when removing the prisms after successful adaptation). Critically, the amplitude of both ERN and Pe were strongly influenced by the magnitude of errors. Error-related ERPs were observed for large deviations, but their amplitudes decreased monotonically when pointing accuracy increased, revealing a parametric modulation of monitoring systems as a function of the severity of errors. These results indicate that early error detection mechanisms do not represent failures in an allor-none manner, but rather encode the degree of mismatch between the actual and expected motor outcome, providing a flexible cognitive control process that can discriminate between different degrees of mismatch between intentions and outcomes.

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“…A role for the PPC during reaching prism adaptation tasks is also supported by lesion studies (Pisella et al 2004). Activity in the cerebellum has been shown to increase during the early phase of prism exposure such that it is elevated in late prism adaptation compared with early adaptation and remains higher for longer durations compared with the PPC (Chapman et al 2010;Luauté et al 2009). Results in patients with cerebellar lesions also support this idea, as they lack the ability to adapt to prismatic displacement during a throwing task (Martin et al 1996a).…”

Section: Discussionmentioning

confidence: 90%

“…Although several brain regions are most likely at work during prism adaptation, two structures in particular have emerged as playing a dominant role: the PPC and the cerebellum. Recent neuroimaging studies found that the anterior intraparietal sulcus (AIP) is active in the early phase of prism exposure when reaching error is high (Chapman et al 2010;Clower et al 1996;Danckert et al 2008;Luauté et al 2009). Luauté et al (2009) suggest that AIP is involved in error detection since its activity is related to the trial-by-trial size of reaching error.…”

Section: Discussionmentioning

confidence: 99%

“…Recent neuroimaging studies found that the anterior intraparietal sulcus (AIP) is active in the early phase of prism exposure when reaching error is high (Chapman et al 2010;Clower et al 1996;Danckert et al 2008;Luauté et al 2009). Luauté et al (2009) suggest that AIP is involved in error detection since its activity is related to the trial-by-trial size of reaching error. A role for the PPC during reaching prism adaptation tasks is also supported by lesion studies (Pisella et al 2004).…”

Section: Discussionmentioning

confidence: 99%

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Prism adaptation and generalization during visually guided locomotor tasks

Alexander

Flodin

Marigold

2011

Journal of Neurophysiology

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Alexander MS, Flodin BW, Marigold DS. Prism adaptation and generalization during visually guided locomotor tasks. J Neurophysiol 106: 860 -871, 2011. First published May 25, 2011 doi:10.1152/jn.01040.2010.-The ability of individuals to adapt locomotion to constraints associated with the complex environments normally encountered in everyday life is paramount for survival. Here, we tested the ability of 24 healthy young adults to adapt to a rightward prism shift (ϳ11.3°) while either walking and stepping to targets (i.e., precision stepping task) or stepping over an obstacle (i.e., obstacle avoidance task). We subsequently tested for generalization to the other locomotor task. In the precision stepping task, we determined the lateral end-point error of foot placement from the targets. In the obstacle avoidance task, we determined toe clearance and lateral foot placement distance from the obstacle before and after stepping over the obstacle. We found large, rightward deviations in foot placement on initial exposure to prisms in both tasks. The majority of measures demonstrated adaptation over repeated trials, and adaptation rates were dependent mainly on the task. On removal of the prisms, we observed negative aftereffects for measures of both tasks. Additionally, we found a unilateral symmetric generalization pattern in that the left, but not the right, lower limb indicated generalization across the 2 locomotor tasks. These results indicate that the nervous system is capable of rapidly adapting to a visuomotor mismatch during visually demanding locomotor tasks and that the prism-induced adaptation can, at least partially, generalize across these tasks. The results also support the notion that the nervous system utilizes an internal model for the control of visually guided locomotion.

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Dynamic Changes in Brain Activity during Prism Adaptation

Cited by 218 publications

References 47 publications

Role of the prefrontal cortex in the cognitive control of reaching movements: near-infrared spectroscopy study

Role of the prefrontal cortex in the cognitive control of reaching movements: near-infrared spectroscopy study

Parametric modulation of error-related ERP components by the magnitude of visuo-motor mismatch

Prism adaptation and generalization during visually guided locomotor tasks

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