DXS10011: a hypervariable tetranucleotide STR polymorphism on the X chromosome

Watanabe, Gotaro; Umetsu, Kazuo; Yuasa, Isao; Suzuki, Tomohiko

doi:10.1007/s004149900096

Cited by 26 publications

(18 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sequence of our primer pair 3 is close to the suggestion of Watanabe et al [4] but was slightly changed according to our sequencing data (allele 31.2, 167 bp).…”

Section: Methodsmentioning

confidence: 81%

“…Similarities in the allele distribution seem to exist between Japanese and Vietnamese populations, however, this is based on a relatively small data base. As shown by Matsuki et al [3] and Watanabe et al [4], DXS10011 is a very complex marker and sequencing a high number of PCR products revealed some structural variants within alleles of identical length. The rare allele variant 43.3 containing a 0.3 repeat, seems to be the result of a loss of a single base in the regular repeat region (type A).…”

Section: Discussionmentioning

confidence: 94%

“…Allele frequencies were published for Japanese and German population samples by Matsuki et al [2,3], Watanabe et al [4] and Koyama et al [5]. Two types of the repeat structure (regular and inter-alleles) were described and designed as type A and type B. DXS10011 is located at Xq28 and is physically closely linked to DXS7423 and DXS8377.…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

DXS10011: studies on structure, allele distribution in three populations and genetic linkage to further q-telomeric chromosome X markers

et al. 2004

View full text Add to dashboard Cite

The hypervariable tetranucleotide STR polymorphism DXS10011 is a powerful marker for forensic purposes. Investigation of this STR led to an allele nomenclature which is in consensus with the ISFG recommendations. DXS10011 is located at Xq28 and genetically closely linked to DXS7423 and DXS8377 but is unlinked to HPRTB and more distant X-chromosomal STRs. DXS10011 is a very complex marker exhibiting some structural variants within alleles of identical length. Two types of repeat structure (regular and inter-alleles) are known and described as types A and B. Two SNPs which are in strong linkage disequilibrium to the different sequence types were found in the repeat flanking region. The type A sequence consists of a long stretch of uninterrupted homogenous repeats which is highly susceptible to slippage mutation during male meiosis.

show abstract

“…The sequence of our primer pair 3 is close to the suggestion of Watanabe et al [4] but was slightly changed according to our sequencing data (allele 31.2, 167 bp).…”

Section: Methodsmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

DXS10011: studies on structure, allele distribution in three populations and genetic linkage to further q-telomeric chromosome X markers

et al. 2004

View full text Add to dashboard Cite

show abstract

“…For homogeneity testing in the Japanese and Korean populations, the P-values were 0.0304, 0.4056 and 0.0065 for HumARA, HPRTB and DXS10011, respectively [11,20,21].…”

Section: Population Differences and Linkage Disequilibrium Test For Tmentioning

confidence: 99%

“…In the meantime, additional X-linked STRs (DXS9898, DXS6809, DXS7424 and DXS10011) have been found to be highly informative in several ethnic populations [6,7,8,9,10,11,12]. In the present study, we applied single multiplex PCR to analyze these four X-STRs in a Korean population.…”

Section: Introductionmentioning

confidence: 96%

Genetic characteristics and population study of 4 X-chromosomal STRs in Koreans: evidence for a null allele at DXS9898

et al. 2004

View full text Add to dashboard Cite

The four X-chromosomal short tandem repeats (STRs), DXS9898, DXS6809, DXS7424 and DXS10011 were analyzed by single multiplex PCR in 150 male and 150 female Koreans. The loss of an allele at DXS9898 was observed in 13 out of 450 chromosomes (2.9%) and the PCR analysis showed that the X-chromosome with a null allele at DXS9898 has more than 1 kb deletion at the DXS9898 locus. Statistical analyses for these four X-STRs showed that they are highly informative for forensic application in Koreans. No linkage disequilibrium was observed among these four STRs and the previously reported five polymorphic STRs, HumARA, DXS101, GATA172D05, HPRTB and DXS8377 in Koreans. The test of homogeneity between allele frequencies revealed that there are some discrepancies in allele distributions between Koreans and Germans.

show abstract

Polymorphism of nine X chromosomal STR loci in Koreans

et al. 2002

View full text Add to dashboard Cite

This study describes the polymorphism of the nine STR loci on the X chromosome, DXS6803, DXS8378, GATA164A09, DXS7132, DXS7133, DXS9895, DXS9898, DXS6789, and DXS6795 in Koreans. In each locus, 4-10 alleles were noted and the allelic distribution patterns were the same for males and females. Heterozygosity in females ranged from 0.42 to 0.84. Among the 303 father-daughter or mother-child pairs examined 29 cases of mutation were found, 13 at the DXS6803 locus, 2 at DXS8378, 4 at DXS164A09, 3 at DXS7132, 1 at DXS7133, 2 at DXS9895, 2 at DXS9898 , 1 at DXS6789 and 1 at DXS6795. In 208 families including 180 fathers and 177 mothers, 530 different haplotypes were found. Unlike the STR loci on the Y chromosome, cases showing recombination were frequent, and in combination with mutation this made it difficult to discriminate the exclusion cases from those with mutation or recombination based on the haplotype. Details of X chromosomal STRs in Koreans which would be useful for a future large scale database are described.

show abstract

DXS10011: a hypervariable tetranucleotide STR polymorphism on the X chromosome

Cited by 26 publications

References 1 publication

DXS10011: studies on structure, allele distribution in three populations and genetic linkage to further q-telomeric chromosome X markers

DXS10011: studies on structure, allele distribution in three populations and genetic linkage to further q-telomeric chromosome X markers

Genetic characteristics and population study of 4 X-chromosomal STRs in Koreans: evidence for a null allele at DXS9898

Polymorphism of nine X chromosomal STR loci in Koreans

Contact Info

Product

Resources

About