Duration of spermatogenesis and sperm transit time through the epididymis in the Piau boar

França, Luiz R.; Cardoso, F.M.

doi:10.1016/s0040-8166(98)80038-4

Cited by 56 publications

(35 citation statements)

References 18 publications

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“…The timing of appearance of spermatocytes or spermatozoa in the xenografts was similar to those observed in developing boars [33,34]. Zeng et al [35] demonstrated that the length of the spematogenic cycle in porcine xenografts implanted into immunodeficient mice was about 9 days, which is similar to that observed in boars [33,36]. However, spermatogenesis in the grafted tissues did not reach the quantitatively normal levels observed in young adult boars.…”

Section: Inhibin and Fsh In Host Mousesupporting

confidence: 55%

Endocrine Status and Development of Porcine Testicular Tissues in Host Mice

Kaneko

Kikuchi

Nakai

et al. 2008

Journal of Reproduction and Development

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Abstract. Clarification of the endocrine status of host mice provides us with basic knowledge with which we can manipulate the growth and function of xenografted testicular tissues. We investigated the hormonal profiles of castrated mice grafted with porcine immature testicular tissues from 30 to 210 or more days after grafting (day 0= castration and grafting). The serum follicle stimulating hormone (FSH) concentrations of the host mice declined (P<0.05) from day 60 compared with those of the castrated, ungrafted mice. The serum inhibin and testosterone levels were higher (P<0.05) than those in the castrated, ungrafted mice from days 30 and 90 days, respectively. The inhibin levels further increased (P<0.05) from day 90, during which time the levels were higher (P<0.05) than those in the intact male mice. In the grafts, formation of lumens occurred in the seminiferous cords on day 90 and spermatozoa appeared in the lumens from day 120. However, spermatogenesis in the grafts did not reach the qualitatively normal levels observed in adult boars. The intensity of the immune reaction to inhibin α subunits in the Sertoli cells of the grafts decreased with differentiation of the seminiferous tubules. The present findings indicate that a feedback loop was established between the mouse hypothalamo-pituitary axis and the grafted porcine tissues from 60 days post-grafting. The results also indicate that the serum inhibin levels in the host mice remained high even after the appearance of lumens in the seminiferous tubules of the grafted tissues; this is strikingly different to the situation in normal male animals, in which the serum inhibin levels decline at around the time of tubular differentiation. The lack of efferent ducts in the tubules of the grafted tissues probably caused the accumulation of inhibin to be released into the lumens, resulting in high concentrations of circulating inhibin. These high levels of inhibin may directly affect spermatogenic activity and suppress FSH secretion. [6], and then xenografted into immunodeficient mice. Successful recovery of spermatozoa from the grafts has been proven in several species (pigs [3], cats [5] and rhesus monkeys [6]). However, no progeny have been obtained from spermatozoa isolated from the xenografts of these animals. Clarification of the endocrine status of the host mouse would likely help us to improve spermatogenesis in grafted testicular tissues, since development of the testis is controlled by the balance between the pituitary hormones, which stimulate testicular function, and testicular hormones, which alter the secretion of the pituitary hormones [7]. To date, the hormonal characteristics of host mice have been elucidated only after grafting of murine testicular tissues [8]; the study indicated that a feedback loop was established between the graft and the host's hypothalamo-pituitary 2 weeks after grafting, when the graft acquired the ability to produce testosterone. However, the time required for testicular maturation is much longer in large animals, such ...

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Section: Inhibin and Fsh In Host Mousesupporting

confidence: 55%

Endocrine Status and Development of Porcine Testicular Tissues in Host Mice

Kaneko

Kikuchi

Nakai

et al. 2008

Journal of Reproduction and Development

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“…The meiotic phase was longer than what is currently observed the observed in domestic mammals -10% [7] but similar to A. cursor and O. nigripes [27]. The eight stages of the SEC were distributed in a segmental arrangement along the seminiferous tubule, a pattern described for most mammals, except primates [28]. The average frequency of each stage of the SEC is considered a constant variable in individuals of the same species [7].…”

Section: Discussionmentioning

confidence: 67%

Germ cells and the seminiferous epithelium cycle in the wild rodent Oxymycterus rufus (Rodentia: Cricetidae)

Carolina¹,

Morais²,

Balarini³

et al. 2016

IOSR

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“…The testicular parenchyma is a functional part of the testis and consists of two compartments: a tubular compartment and an interstitial one (21). Tubular measurement is one of the approaches used as a spermatogenic indicator in experiments related to the testicular function (3,6,20). Differences between the parameters in the experimental and control groups depending on omega-3 and -6 polyunsaturated fatty acids are presented in Table 3.…”

Section: Resultsmentioning

confidence: 99%

Histomorphometric study on testes in rams fed with linseed oil rich in omega-3 and -6 polyunsaturated fatty acids

Vaškas¹,

Šiukščius²,

Razmaitė³

et al. 2017

Medycyna Weterynaryjna

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Many researchers have pointed out that the intake of omega-3 and -6 fatty acids is beneficial to animal health and reproductive capacity, but the effect of fatty acids on the histomorphology of ram testes is still unknown. The aim of this study was to investigate the effect of linseed oil containing polyunsaturated fatty acids on the morphology and histomorphometric characteristics of ram testis and epididymis. Testes of 12 Lithuanian local coarse wool rams were investigated histomorphologically and histomorphometrically in the present work. The rams were divided into two groups, an experimental group and a control group following, the principle of analogues – the same origin, age, weight, and condition score. The experimental group (n = 6) received 2% linseed oil sediments while the control group (n = 6) received 1.2% sunflower oil for 9 months. The diameter of testicular tubules and the height of the germinal epithelium, the spermatogenic index and the number of Leydig cells were higher in the experimental group than those in the control group. In addition, the number of degenerated tubules was not significantly lower in the group that received 2% linseed oil sediments. Still, the height of the epididymal epithelium was lower than that in the control group....

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Duration of spermatogenesis and sperm transit time through the epididymis in the Piau boar

Cited by 56 publications

References 18 publications

Endocrine Status and Development of Porcine Testicular Tissues in Host Mice

Endocrine Status and Development of Porcine Testicular Tissues in Host Mice

Germ cells and the seminiferous epithelium cycle in the wild rodent Oxymycterus rufus (Rodentia: Cricetidae)

Histomorphometric study on testes in rams fed with linseed oil rich in omega-3 and -6 polyunsaturated fatty acids

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