Duration of Analgesic Use and Risk of Hearing Loss in Women

Lin, Brian M.; Curhan, Sharon G.; Wang, Molin; Eavey, Roland D.; Stanković, Konstantina M.; Curhan, Gary C.

doi:10.1093/aje/kww154

Cited by 21 publications

(5 citation statements)

References 55 publications

(64 reference statements)

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“…To the best of our knowledge, this is the largest series evaluating HL in AS. Another strength of the our study was that we performed objective audiometry rather than using subjective self‐reported HL, which earlier studies have done to see the relation between NSAID intake and hearing loss . A limitation of the study was that NSAID intake was noted using recall and prescriptions available with the patient rather than by prospective observation of drug intake.…”

Section: Discussionmentioning

confidence: 99%

Hearing loss in ankylosing spondylitis

et al. 2019

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Aim: Several studies have described sensorineural deafness in ankylosing spondylitis (AS) patients while conductive hearing loss has been reported to be rare. In our study we have studied the prevalence of hearing loss (HL) among AS patients and its association with non-steroidal anti-inflammatory drug (NSAID) intake. Methods:We studied 100 AS patients and 40 controls. HL was defined as pure-tone thresholds greater than 20 dB (decibel) in at least two frequencies of the audiogram.Severity of HL was defined as given by World Health Organization. Clinical details and cumulative NSAID doses were noted.Results: Ninety-six of the 100 patients were male with mean age of 32 ± 12 years and mean duration of illness of 8.2 ± 6 years. Median Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI) and cumulative NSAID dose were 3.5 ± 2.2, 2.75 ± 2, 3.7 ± 2.6 and 1202 ± 1290, respectively. Of the 48 with HL, 28 patients had bilateral HL. Twenty-nine patients had pure conductive HL while 16 had mixed HL (components of both sensory and conductive) and 3 had pure sensorineural HL. HL was mild in 38 patients, and moderate to severe in 10 patients. The presence of HL was associated with higher age (P ≤ 0.05). Conductive HL was at low frequency (0.25, 0.5, 1 kHz) in 70% of cases. Sensorineural HL was at high frequency (4, 8 kHz) in 75% of cases. There was no association of HL with disease parameters such as BASMI, BASDI, BASFI or cumulative NSAID dose.Conclusion: HL is common in AS. Conductive HL is more common than sensorineural HL. It is usually mild and occurs at low frequencies. K E Y W O R D Sanalgesics, ankylosing spondylitis, NSAIDs

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Section: Discussionmentioning

confidence: 99%

Hearing loss in ankylosing spondylitis

et al. 2019

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“…30 Associations between several other risk factors and hearing loss have been demonstrated using these assessment methods. [31][32][33][34]…”

Section: Ascertainment Of Hearing Lossmentioning

confidence: 99%

“…Factors considered included age, 35 race, 35 body mass index, 36 waist circumference, 36 alcohol intake, 15,37 trans-fat, 3 long-chain omega-3 polyunsaturated fatty acids, 38 folate, 39,40 beta-carotene, 40 beta-cryptoxanthin, 40 vitamin B 12 , 41 vitamin C, 40 magnesium, 42 physical activity, 36,43 , hypertension, 31 diabetes, 44 tinnitus, 45,46 , acetaminophen use, 32,47 and nonsteroidal anti-inflammatory drug use. 32,47 Covariates were updated based on information provided on the biennial questionnaires. Information on dietary intake was obtained from semiquantitative food frequency questionnaires that were administered every four years.…”

Section: Ascertainment Of Covariatesmentioning

confidence: 99%

Cigarette Smoking, Smoking Cessation, and Risk of Hearing Loss in Women

Lin

Wang

Stanković

et al. 2020

The American Journal of Medicine

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Author contributions: BML and SGC conceived and designed the study. BML, SGC, MW, RE, KMS, MJM, and GCC were involved in the analysis and interpretation of the data. BML and SGC drafted the manuscript. All of the authors had full access to all of the data in the study and take responsibility for the integrity of the data and accuracy of the data analysis. All authors critically reviewed and revised the manuscript for important intellectual content, contributed to the writing, and are in agreement with its submission.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Data Access, Responsibility, and Analysis: BML and SGC had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

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“…Some of the studies reported here showed HL/VL in patients who were on methadone treatment and then overdosed on other drugs, or patients who misused prescription opioids and acetaminophen (Nicoucar et al 2005). Human studies have shown that there is a higher risk of HL with the combined use of other analgesics and acetaminophen (Curhan et al 2010, 2012; Lin et al 2017), which may be linked to an oxidative stress mechanism (Yorgason et al 2010; Kalinec et al 2014; McGill et al 2016). Given these concomitant drug uses, it is difficult to extrapolate whether the HL/VL was related to one specific substance versus the other or polysubstance use, confounding the results.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Substance Misuse on Auditory and Vestibular Function: A Systematic Review

Chiao,

Hughes,

Karimuddanahalli Premkumar

et al. 2023

Ear &Amp; Hearing

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Background: Chronic substance misuse is an ongoing and significant public health concern. Among a myriad of health complications that can occur, substance misuse potentially causes ototoxic effects. Case reports, retrospective chart data, and a few cohort studies suggest that certain prescription opioids and illicit drugs can have either temporary or permanent effects on auditory and/or vestibular function. Given the steady rise of people with a substance-use disorder (SUD), it is of growing importance that audiologists and otolaryngologists have an insight into the potential ototoxic effects of substance misuse. Objectives: A systematic review was conducted to (1) synthesize the literature on the illicit drugs, prescription opioids, and alcohol misuse on the auditory and vestibular systems, (2) highlight common hearing and vestibular impairments for each substance class, and (3) discuss the limitations of the literature, the potential mechanisms, and clinical implications for clinicians who may encounter patients with hearing or vestibular loss related to substance misuse, and describe opportunities for further study. Design: Systematic searches were performed via PubMed, Scopus, and Google Scholar, and the final updated search was conducted through March 30, 2022. Inclusion criteria included peer-reviewed articles, regardless of study design, from inception until the present that included adults with chronic substance misuse and hearing and/or vestibular complaints. Articles that focused on the acute effects of substances in healthy people, ototoxicity from already known ototoxic medications, the relationship between hearing loss and development of a SUD, articles not available in English, animal work, and duplicates were excluded. Information on the population (adults), outcomes (hearing and/or vestibular data results), and study design (e.g., case report, cohort) were extracted. A meta-analysis could not be performed because more than 60% of the studies were single-case reports or small cohort. Results: The full text of 67 studies that met the eligibility criteria were selected for the review. Overall, 21 studies reported associations between HL/VL related to illicit drug misuse, 28 studies reported HL/VL from prescription opioids, and 20 studies reported HL/VL related to chronic alcohol misuse (2 studies spanned more than one category). Synthesis of the findings suggested that the misuse and/or overdose of amphetamines and cocaine was associated with sudden, bilateral, and temporary HL, whereas HL from the combination of a stimulant and an opioid often presented with greater HL in the mid-frequency range. Reports of temporary vertigo or imbalance were mainly associated with illicit drugs. HL associated with misuse of prescription opioids was typically sudden or rapidly progressive, bilateral, moderately severe to profound, and in almost all cases permanent. The misuse of prescription opioids occasionally resulted in peripheral VL, especially when the opioid misuse was long term. Chronic alcohol misuse tended to associate with high-frequency sudden or progressive sensorineural hearing loss, or retrocochlear dysfunction, and a high occurrence of central vestibular dysfunction and imbalance. Conclusions: Overall, chronic substance misuse associates with potential ototoxic effects, resulting in temporary or permanent hearing and/or vestibular dysfunction. However, there are notable limitations to the evidence from the extant literature including a lack of objective test measures used to describe hearing or vestibular effects associated with substance misuse, small study sample sizes, reliance on case studies, lack of controlling for confounders related to health, age, sex, and other substance-use factors. Future large-scale studies with prospective study designs are needed to further ascertain the role and risk factors of substance misuse on auditory and vestibular function and to further clinical management practices.

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Duration of Analgesic Use and Risk of Hearing Loss in Women

Cited by 21 publications

References 55 publications

Hearing loss in ankylosing spondylitis

Hearing loss in ankylosing spondylitis

Cigarette Smoking, Smoking Cessation, and Risk of Hearing Loss in Women

The Effects of Substance Misuse on Auditory and Vestibular Function: A Systematic Review

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