Hearing loss in ankylosing spondylitis

Ajmani, Sajal; Keshri, Amit; Srivastava, Rakesh K.; Aggarwal, Amita; Lawrence, Able

doi:10.1111/1756-185x.13560

Cited by 11 publications

(16 citation statements)

References 23 publications

(26 reference statements)

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“…The prevalence of AS in males was found to be 0.42%, which is 2.8 times higher than that in females, resulting in a statistically significant difference between the sexes. This finding is consistent with the general AS epidemiological finding that males have a higher prevalence than females [1,4,31]. The prevalence of AS in both the southern and northern populations of mainland China in this study was 0.31%, indicating no significant difference according to geographical region.…”

Section: Discussionsupporting

confidence: 92%

“…The results of the present study showed that the prevalence rates are higher than 0.24% in the community population and 0.23% in the military population reported in Swee's 2007 research [1] and exhibit an increasing tendency. The global average prevalence of AS is 0.1-1% [4,29,30]. The prevalence rates of AS in China are in the relatively low range compared to those worldwide, for example, the rates reported in the current study are lower than those reported in Norway (1.1-1.4%) and in indigenous Alaskan populations (0.4%).…”

Section: Discussioncontrasting

confidence: 62%

“…AS is a subtype of axSpA and presents typical radiographic manifestations. AS can cause physiological damage, disability, and neurological deafness [3,4], leading to reduced quality of life (QOL) and placing a substantial financial burden on patients, their families and society [5][6][7]. An American study on the direct and indirect economic burden of patients with AS showed that the average direct medical costs were $2674 during the first year, while the indirect costs were $4945 [8].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of ankylosing spondylitis in a Chinese population: a systematic review and meta-analysis

Zhao

Huang

et al. 2020

Rheumatol Int

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Ankylosing spondylitis (AS) is a common inflammatory rheumatic disease that affects the axial skeleton. In this study, we systematically reviewed Chinese AS epidemiological studies from the past 15 years to elucidate its prevalence and provide scientific data for China's health care system. AS epidemiological research in China was summarized by conducting a literature review. A review and statistical analysis of the literature on the epidemiology of AS in mainland China published from May 2005 to May 2019 were performed via a meta-analysis. We calculated the prevalence of AS and analysed differences by sex, region, and population source using STATA12.0 software. Eleven papers including 122,558 subjects from mainland China were included. Over the past 15 years, the total prevalence of AS in mainland China was 0.29% (95% CI 0.22-0.35%), ranging from 0.42% (95% CI 0.31-0.52%) in males to 0.15% (95% CI 0.13-0.18%) in females; the difference in the prevalence of AS by sex was statistically significant (P < 0.001). The prevalence of AS in both southern and northern China was 0.31% (95% CI 0.21-0.42% and 0.21-0.40%, respectively), with no significant difference noted (P = 0.816 > 0.005). The prevalence of AS in Chinese military populations was 0.27% (95% CI 0.09-0.45%), and in community populations, it was 0.29% (95% CI 0.23-0.35%). There was no statistically significant difference in the prevalence of AS by sampling resource (P = 0.115 > 0.005). The prevalence of AS in China was 0.29% and continues to increase. Sex differences in its prevalence were identified; the prevalence rate was 2.8 times higher in males than in females. Epidemiologists in China should formulate precise scientific investigations to provide additional authoritative epidemiological data for the prevention and treatment of AS.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

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Prevalence of ankylosing spondylitis in a Chinese population: a systematic review and meta-analysis

Zhao

Huang

et al. 2020

Rheumatol Int

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“…The longer the course of the disease, the higher the activity of the disease and the more obvious are the systemic symptoms. It was found in studies with an average course of > 8 years that the longer the duration of AS, the greater the risk of cardiovascular disease, hearing loss, and poor physical mobility [ 70 , 71 ]. At the same time, AS causes the lung interstitium to develop lesions at an early stage, and the range of lesions increases with the duration of the disease [ 72 ].…”

Section: Discussionmentioning

confidence: 99%

Serum RANKL levels in Chinese patients with ankylosing spondylitis: a meta-analysis

Zhang

Peng

et al. 2021

J Orthop Surg Res

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Objective We aimed to determine the association between serum receptor activator of nuclear factor-kappa B ligand (sRANKL) levels and ankylosing spondylitis (AS) in Chinese patients. Methods The PubMed, Cochrane Library, Embase, Chinese Biomedical Database, Web of Science, China National Knowledge Infrastructure, VIP, and Wan Fang databases were searched for studies conducted before October 1, 2020, without language restrictions. STATA version 12.0 and Revman version 5.3 were used to analyze the data. The standard mean differences (SMDs) and corresponding 95% confidence intervals (95% CIs) were calculated. Results Twelve clinical case–control studies, including 585 patients with AS and 423 healthy controls, were included. The combined SMD for sRANKL suggested that the sRANKL level was significantly higher in Chinese patients with AS than in healthy controls (SMD: 3.27, 95% CI 2.11–4.43, P < 0.00001). Serum RANKL-related factor osteoprotegerin (OPG) levels (SMD: 0.86, 95% CI 0.09–1.64, P < 0.03) were lower in the Chinese patients with AS than in healthy controls, and the RANKL/OPG ratio (SMD = 1.05, 95% CI 0.64–1.46, P < 0.00001) in Chinese patients with AS was approximately the same as that of healthy controls. Subgroup analysis indicated that patients from North and South China had higher sRANKL levels than controls; the sRANKL levels of patients from South China were higher in the subgroup with a Bath Ankylosing Spondylitis Functional Index (BASFI) of > 4 than those of patients in other subgroups. In terms of duration, patients with AS for > 8 years had higher sRANKL levels than health controls. Other subgroup analyses were conducted by region, language, source of control, age, and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). In these subgroups, the sRANKL levels were significantly higher in the patients with AS than in healthy controls. The BASFI and BASDAI were sources of heterogeneity. Conclusions The sRANKL levels are higher in Chinese patients with AS, especially among those from South China. sRANKL levels may be positively correlated with the pathogenesis of AS among Chinese patients.

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“…(3) AS is a subtype of axSpA and presents typical radiographic man ifestations. AS can cause physiological damage, d isability, and neurological deafness (4), (5) leading to reduced quality of life (QOL) and placing a substantial financial burden (6)Health-related quality of life (HRQo L) co mprises the functional effect of the disorder and its treat ment, as perceived by the patient. Patients with AS frequently report high levels of pain, gradual affection of spinal mov ement, fatigue following simple activity, sleep d isturbance and depression (7) Poor Qo L in AS patients was significantly associated with more severe rad iological changes, as indicated by severe kyphosis (8) The strongest predictors of ASQo L were BASDA I, ASDAS, peripheral arthritis and BASFI.…”

Section: Introductionmentioning

confidence: 99%

Health Related Quality Of Life Of Patient With Ankylosing Spondylitis Attending Baghdad Teaching Hospital

Abed¹,

Al-Sarray²,

Hafidh³

2021

ASRO

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Background: Anky losing Spondylitis is a comp lex systemic rheumatological d isease It primarily affects the axial joints, most notably the sacroiliac joints. Other sites include the spine, peripheral jo ints, and entheses; inflammatory enthesopathy progressing to ossification and an kylosis is the pathologic basis for the disease which o ften causes severe disability and impaired quality of life. Objecti ves: To assess health-related quality of life (HRQo L) and associated variables in Iraqi an kylosing spondylitis (AS) patients .Methods: A descriptive; cross sectional study conducted ,included 278 patients The data collection continued for the period starting on 5th of May 2019 to the 30th of September 2019. Results: The results of demographic data was conducted on patients with their mean age(38.9±9.8) years ranging from (17-75) years and the highest percentage (37.1%)were in the age group (30 -39) years and the lowest percentage(1.4) were in the age group (age>60) years, most of studied sample were males (84.5%) and married (74.8%),regard ing Educational level the highest percentage (33.8%) fro m Co llege and higher educational level, the lowest percentage fro m illiterate, the majority of studied samp le (39.9%) were fair score and (33.8%) were poor score of quality of life Conclusion: QoL of Ankylosing Spondylitis patients in Baghdad Teaching Hospital / had acceptable level. Most cases were male, married, in the age group (30 -39) year and fro m urban area. Positive family h istory & HLA typing we re reported in 27.7%, 47.1% of total cases respectively. Most cases of Ankylosing Spondylitis (75.9%) co mmencement Biological therapy. Recommendations: Early d iagnosis and effective treat ment provides improvement of pain, fat igue, disease activity . Educating the patient about the disease may reduce bad feelings and promote coping with the disease illness and QOL imp rovement. More research can lead to interventions to improving the quality of life of ankylosing spondylitis patients.

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Hearing loss in ankylosing spondylitis

Cited by 11 publications

References 23 publications

Prevalence of ankylosing spondylitis in a Chinese population: a systematic review and meta-analysis

Prevalence of ankylosing spondylitis in a Chinese population: a systematic review and meta-analysis

Serum RANKL levels in Chinese patients with ankylosing spondylitis: a meta-analysis

Health Related Quality Of Life Of Patient With Ankylosing Spondylitis Attending Baghdad Teaching Hospital

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