Duration of acidosis and recovery determine preretinal neovascularization in the rat model of acidosis-induced retinopathy

Chen, Yi; Zhang, Shuichen; Karger, Randy A.; Lanier, William L.; Holmes, Jonathan M.

doi:10.1076/ceyr.24.4.281.8410

Cited by 7 publications

(3 citation statements)

References 8 publications

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“…The two known major risk factors of ROP are extreme prematurity (1–5) and hyperoxia (3,6). Other risk factors for ROP have been previously reported, including hyperglycemia (4), apnea (6), hypoxia (7), bacterial and fungal late‐onset sepsis (1,8), multiple blood transfusions (3,9,10), metabolic acidosis in animals (11,12), hypercapnia in animals and humans (13), small for gestational age (SGA) status (5,14), male gender (5), genetic factors (15), overexpression of vascular endothelial growth factor (VEGF) (16–19) and low serum level of insulin growth factor‐1 (IGF‐1) (7). In addition, severity of respiratory distress syndrome (RDS) was shown to be significantly associated with development of ROP (9).…”

Section: Introductionmentioning

confidence: 99%

Late postnatal systemic steroids predispose to retinopathy of prematurity in very‐low‐birth‐weight infants: a comparative study

et al. 2008

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Section: Introductionmentioning

confidence: 99%

Late postnatal systemic steroids predispose to retinopathy of prematurity in very‐low‐birth‐weight infants: a comparative study

et al. 2008

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“…Estrogen and the prostaglandin-cyclo-oxygenase pathway may function as modulators of VEGF expression under different oxygen conditions [15,16] . Periods of acidosis lead to neovascularization in the rat and a brief episode of systemic acidosis may be a risk factor for ROP in human neonates [17] .…”

Section: Introductionmentioning

confidence: 99%

Does Insulin-Like Growth Factor 1 Contribute in Red Blood Cell Transfusions to the Pathogenesis of Retinopathy of Prematurity during Retinal Neovascularization?

Hübler

Knote²,

Kauf³

et al. 2006

Neonatology

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Background: Red blood cell (RBC) transfusions are associated with the development of retinopathy of prematurity (ROP). During the period of retinal neovascularization a rise of insulin-like growth factor 1 (IGF-1) may trigger rapid growth of new blood vessels. Objectives: To study endocrine factors in RBC transfusions that might be of importance for ROP. Methods: IGF-1, IGF-2 and their binding proteins 1–3 (IGFBP-1–3) were determined by radioimmunoassays in 7 very-low-birthweight (VLBW) infants with ROP ≧ stage 2 receiving a RBC transfusion, in 10 controls (VLBW infants with ROP ≤ stage 1, no transfusion), in supernatants of 7 RBCs and of 5 washed RBCs (WRBC). Results: IGF-1 (mean ± SD) in infants with ROP was 20.0 ± 4.2 µg/l, in controls 35.9 ± 15.2 µg/l (Mann-Whitney U test, p = 0.030). IGF-1 in RBC was 12.88 ± 5.03 µg/l and in WRBC 0.45 ± 0.74 µg/l (average of the three-course washing procedure). IGF-2 in infants with ROP was 485.67 ± 158.73 µg/l, in controls 389.9 ± 102.8 µg/l (not significant), in RBC 109.50 ± 117.89 µg/l, in WRBC 61.07 ± 30.0 µg/l. Except for IGFBP-3 other IGFBPs were barely or not detectable in RBC or WRBC. Conclusions: Considering lower IGF-1 concentrations in preterm infants than in adults (factor 20), the IGF-1 in RBC transfusions is equivalent to a single dose of 1 µg/kg IGF-1 (5–10% of the adult dose with proved metabolic responses). Endocrinological relationships between the donor’s load and the acceptor’s individual features are a new aspect of potential side effects of RBC transfusions. Further research is necessary to clarify the share of the described IGF administration on the development of ROP.

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“…Low pH in the ELGAN cohort has been associated with severe ROP 40 . In animal models, metabolic acidosis increases retinal neovascularization and development of ROP 41 . To what extent acidemia contributes to organ damage remains to be clarified.…”

Section: Discussionmentioning

confidence: 99%

Antecedents and correlates of visual field deficits in children born extremely preterm

Holm

Msall

Skranes

et al. 2015

European Journal of Paediatric Neurology

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Aim We sought to identify the antecedents and correlates of visual field deficits (VFDs) at age 2 years among infants born before the 28th week of gestation. Methods The visual fields of 1023 infants were assessed by confrontation at age 2 years. We compared the ante-and postnatal characteristics and exposures of the 65 infants with a VFD to their peers who did not have a VFD. We used time-oriented logistic regression risk models to assess the associations of potential antecedents and correlates with a VFD. Results In the final regression model, VFD was associated with maternal consumption of aspirin during the current pregnancy, recurring/persistent acidemia during the first 3 postnatal days, cerebral ventriculomegaly seen on neonatal ultrasound, prethreshold retinopathy of prematurity (ROP), and supplemental oxygen and ventilator dependence at 36 weeks post-menstrual age. Birth before the 27th week was also associated with increased risk, but its significance was diminished by the addition of postnatal variables. Conclusion In this sample of extremely preterm born infants, antenatal as well as early and late postnatal characteristics and exposures are associated with an increased risk of having a VFD. Our study adds to our knowledge about the complex etiology of visual deficits of prematurity, and supports a multifactorial cause of these deficits.

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Duration of acidosis and recovery determine preretinal neovascularization in the rat model of acidosis-induced retinopathy

Cited by 7 publications

References 8 publications

Late postnatal systemic steroids predispose to retinopathy of prematurity in very‐low‐birth‐weight infants: a comparative study

Late postnatal systemic steroids predispose to retinopathy of prematurity in very‐low‐birth‐weight infants: a comparative study

Does Insulin-Like Growth Factor 1 Contribute in Red Blood Cell Transfusions to the Pathogenesis of Retinopathy of Prematurity during Retinal Neovascularization?

Antecedents and correlates of visual field deficits in children born extremely preterm

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