Late postnatal systemic steroids predispose to retinopathy of prematurity in very‐low‐birth‐weight infants: a comparative study

Abstract

Significantly more neonates in the ROP group received late postnatal systemic steroids as compared to controls. We speculate that steroids, by altering insulin growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) expression, might contribute to the pathogenesis of ROP.

Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity

“…On the other hand, Sobel et al (238) showed a reduction in the need for cryotherapy with prolonged dexamethasone. Several other reports confirmed the findings of Baton et al (237) of an increased risk of ROP with steroids (239)(240)(241)(242)(243)(244), while other studies showed no association (245)(246)(247)(248)(249). However, meta-analyses showed that early exposure to steroids was not associated with a risk of severe ROP (250,251), while exposure at > 7days (252) and >3weeks (253), caused an increase in severe ROP.…”

Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity

“…On the other hand, Sobel et al (238) showed a reduction in the need for cryotherapy with prolonged dexamethasone. Several other reports confirmed the findings of Baton et al (237) of an increased risk of ROP with steroids (239)(240)(241)(242)(243)(244), while other studies showed no association (245)(246)(247)(248)(249). However, meta-analyses showed that early exposure to steroids was not associated with a risk of severe ROP (250,251), while exposure at > 7days (252) and >3weeks (253), caused an increase in severe ROP.…”

Early Experience with Diode Laser Combined with Systemic Steroid Therapy for Severe Stages of Retinopathy of Prematurity

“…Most recent reports point out the presence of normal cerebral development in only 23.5% of VLBW newborns, confirming global, mental and psychomotor retardation in the remaining group with the lack of systemic steroids application [17]. Contrary to that, other data in the literature also underline that the majority of prematures exposed to Dexamethasone in BPD do not develop cerebral palsy or global developmental disability, nevertheless one cannot exclude other more subtle adverse effects after steroids in further periods of childhood [1,8,29,30,[33][34][35].…”

A Psychoneuroimmunologic Examination of Cumulative Perinatal Steroid Exposures and Preterm Infant Behavioral Follow-Up

“…ROP can result in detached retinas, nearsightedness, eye misalignment, and blindness. Smolkin et al (2008) found that the incidence of ROP was higher in neonates who received late postnatal systemic steroids. They suggested that steroids may alter insulin growth factor 1 (IGF-1) and vascular endothelial growth factor (VEGF) expression, which might contribute to the pathogenesis of ROP.…”

Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity

“…On the other hand, Sobel et al (238) showed a reduction in the need for cryotherapy with prolonged dexamethasone. Several other reports confirmed the findings of Baton et al (237) of an increased risk of ROP with steroids (239)(240)(241)(242)(243)(244), while other studies showed no association (245)(246)(247)(248)(249). However, meta-analyses showed that early exposure to steroids was not associated with a risk of severe ROP (250,251), while exposure at > 7days (252) and >3weeks (253), caused an increase in severe ROP.…”

Early Experience with Diode Laser Combined with Systemic Steroid Therapy for Severe Stages of Retinopathy of Prematurity

“…Most recent reports point out the presence of normal cerebral development in only 23.5% of VLBW newborns, confirming global, mental and psychomotor retardation in the remaining group with the lack of systemic steroids application [17]. Contrary to that, other data in the literature also underline that the majority of prematures exposed to Dexamethasone in BPD do not develop cerebral palsy or global developmental disability, nevertheless one cannot exclude other more subtle adverse effects after steroids in further periods of childhood [1,8,29,30,[33][34][35].…”

A Psychoneuroimmunologic Examination of Cumulative Perinatal Steroid Exposures and Preterm Infant Behavioral Follow-Up

“…ROP can result in detached retinas, nearsightedness, eye misalignment, and blindness. Smolkin et al (2008) found that the incidence of ROP was higher in neonates who received late postnatal systemic steroids. They suggested that steroids may alter insulin growth factor 1 (IGF-1) and vascular endothelial growth factor (VEGF) expression, which might contribute to the pathogenesis of ROP.…”

Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity

“…On the other hand, Sobel et al (238) showed a reduction in the need for cryotherapy with prolonged dexamethasone. Several other reports confirmed the findings of Baton et al (237) of an increased risk of ROP with steroids (239)(240)(241)(242)(243)(244), while other studies showed no association (245)(246)(247)(248)(249). However, meta-analyses showed that early exposure to steroids was not associated with a risk of severe ROP (250,251), while exposure at > 7days (252) and >3weeks (253), caused an increase in severe ROP.…”

Early Experience with Diode Laser Combined with Systemic Steroid Therapy for Severe Stages of Retinopathy of Prematurity

“…Most recent reports point out the presence of normal cerebral development in only 23.5% of VLBW newborns, confirming global, mental and psychomotor retardation in the remaining group with the lack of systemic steroids application [17]. Contrary to that, other data in the literature also underline that the majority of prematures exposed to Dexamethasone in BPD do not develop cerebral palsy or global developmental disability, nevertheless one cannot exclude other more subtle adverse effects after steroids in further periods of childhood [1,8,29,30,[33][34][35].…”

A Psychoneuroimmunologic Examination of Cumulative Perinatal Steroid Exposures and Preterm Infant Behavioral Follow-Up

“…ROP can result in detached retinas, nearsightedness, eye misalignment, and blindness. Smolkin et al (2008) found that the incidence of ROP was higher in neonates who received late postnatal systemic steroids. They suggested that steroids may alter insulin growth factor 1 (IGF-1) and vascular endothelial growth factor (VEGF) expression, which might contribute to the pathogenesis of ROP.…”