Dural Metastasis of Atypical Extraventricular Neurocytoma with the Codeletion of Chromosomes 1p/19q

Wang, L; Chen, G; Wei, Hongquan; Liu, F; Hu, Hang; Zhang, J

doi:10.1177/147323001103900549

Cited by 4 publications

(2 citation statements)

References 21 publications

(15 reference statements)

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“…Stapleton et al recently reported a rare case in the pediatric population of a diffuse CN with craniospinal dissemination that was identified at the time of the initial diagnosis by the immunohistochemical results of an elevated Ki-67 proliferation index (53). To date, there have been five reported cases of EVN with craniospinal dissemination (8,30,49,54–56), including four males (7, 24, 48 and 75 years old) and one female (71 years old). Two of the patients showed drop dural metastasis and one tumor was initially located in the sellar region and was associated with multiple remote disseminations in the spinal cord and drop metastasis in the frontal cranial base in the route of the initial surgery (54).…”

Section: Discussionmentioning

confidence: 99%

“…Two of the patients showed drop dural metastasis and one tumor was initially located in the sellar region and was associated with multiple remote disseminations in the spinal cord and drop metastasis in the frontal cranial base in the route of the initial surgery (54). The other tumor was initially located in the left occipital-parietal lobe and was associated with drop metastasis along the frontotemporal dura with an intratumoral hemorrhage outside the field of the initial surgery (56). The initial tumor of the patient in the present case report was located in the right frontal lobe.…”

Section: Discussionmentioning

confidence: 99%

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Extraventricular neurocytoma in pediatric populations: A case report and review of the literature

Han

Niu

Wang³

et al. 2013

Oncology Letters

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Extraventricular neurocytomas (EVNs) are rare neuronal tumors included in the definition of neoplasms in the 2007 World Health Organization classification of tumors of the central nervous system. Although a small case series of EVNs in adults has been previously reported, EVNs in pediatric populations are extremely rare. The current case report presents the clinicopathological features of an EVN in a 2-year-old female who presented with nausea and vomiting that had lasted for five days. In addition, an analysis of the imaging features, histology, treatment and prognosis of these reported rare lesions is presented. Immunohistochemically, EVNs are characterized by the robust expression of synaptophysin, but with a lack of oligodendrocyte transcription factor 2, isocitrate dehydrogenase enzyme isoform 1 (IDH1) R132/IDH2 R172 mutations and p53 immunoexpression. The treatment for EVNs in pediatric and adult populations is gross total resection, with post-operative radiation reserved for subtotal resection or recurrent disease. In addition, drop metastasis must be carefully avoided.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Extraventricular neurocytoma in pediatric populations: A case report and review of the literature

Han

Niu

Wang³

et al. 2013

Oncology Letters

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Extraventricular neurocytoma of the sellar region with spinal dissemination

Kawaji¹,

Saito²,

Amano³

et al. 2012

Brain Tumor Pathol

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Extraventricular neurocytoma (EVN) is a rare tumor that mainly occurs in the cerebral hemispheres and spinal cord. Sellar neurocytoma is extremely rare, with only two previously reported cases. We report a sellar EVN in a 48-year-old man presenting with visual impairment. This tumor was partially resected. The residual tumor disappeared on MRI with adjuvant radiotherapy. However, 2 years later the tumor recurred with craniospinal dissemination, which is also very rare, with only four previously reported cases. The recurrent tumor showed atypical features with an MIB-1 LI score of 3 %. It is suggested that postoperative adjuvant radiation therapy with long-term follow-up is required for incompletely resected EVN.

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A clinicopathologic study of extraventricular neurocytoma

Ouyang

Wang

et al. 2016

J Neurooncol

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In 2007, extraventricular neurocytoma was classified as a separate entity among glioneuronal tumors. However, extraventricular neurocytoma is not fully understood and may be misdiagnosed. Here, we describe the clinical and pathological features, prognoses, and treatments of 13 extraventricular neurocytoma cases, and compare their immunophenotypes with those of oligodendroglioma, diffuse astrocytoma, and ependymoma. Six typical and 7 atypical cases comprised the 13 extraventricular neurocytoma cases. Histological features included oligodendroglioma-like perinuclear halo, neuropil-like matrix, ganglion or ganglioid cells, perivascular pseudorosettes, vessel hyalinization, calcifications, and myxoid degeneration. Atypical histological features included increased mitotic figures, focal necrosis, endothelial cell proliferation, and/or a Ki-67 index of >2%. All lesions expressed synaptophysin and microtubule-associated protein-2, which distinguished them from other similar tumors. Two patients with atypical extraventricular neurocytoma had tumor recurrence, one of whom had cerebrospinal fluid dissemination, suggesting that atypical histological features might represent adverse prognostic factors. In conclusion, the present study identified morphological and immunohistochemical features that would aid the differential diagnosis of extraventricular neurocytoma. In addition, radiotherapy with subtotal resection could be considered an effective treatment for extraventricular neurocytoma, but because a pediatric patient died of intracranial hemorrhage during radiotherapy, radiotherapy-related side effects should be considered, especially when treating children. Additional cases with long-term follow-up are needed to develop optimal management protocols for extraventricular neurocytoma.

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Dural Metastasis of Atypical Extraventricular Neurocytoma with the Codeletion of Chromosomes 1p/19q

Abstract: Extraventricular neurocytoma (EVN) is

Cited by 4 publications

References 21 publications

Extraventricular neurocytoma in pediatric populations: A case report and review of the literature

Extraventricular neurocytoma in pediatric populations: A case report and review of the literature

Extraventricular neurocytoma of the sellar region with spinal dissemination

A clinicopathologic study of extraventricular neurocytoma

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