Extraventricular neurocytoma in pediatric populations: A case report and review of the literature

Han, Lin; Niu, Hongquan; Wang, Junwen; Wan, Feng; Shu, Kai; Ke, Chao; Lei, Ting

doi:10.3892/ol.2013.1583

Cited by 22 publications

(16 citation statements)

References 46 publications

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“…The incidence of pediatric EVN is so low that the incidence has been estimated only from a number of case reports and series. A review of pediatric EVNs in the PubMed database provided about 50 cases [ 3 4 5 ]. However, to our knowledge, there has been no case report of a pediatric EVN located in the hypothalamic region.…”

Section: Discussionmentioning

confidence: 99%

Hypothalamic Extraventricular Neurocytoma (EVN) in a Pediatric Patient: A Case of EVN Treated with Subtotal Removal Followed by Adjuvant Radiotherapy

Cho

Joo

Kim

et al. 2016

Brain Tumor Res Treat

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Extra ventricular neurocytoma (EVN) is a rare brain tumor with histologic features similar with a central neurocytoma, but located outside of the ventricular system. In this study, we present an unusual case of hypothalamic EVN in a 14-year-old patient. The patient underwent subtotal removal and had tumor relapse. The patient was then treated using intensity modulated radiation therapy, and the tumor remained stable for 24 months. This case report may be important in that this is the first pediatric case of EVN located in the hypothalamic region. EVN has similar radiologic features with pilocytic astrocytomas and therefore a hypothalamic EVN may be misdiagnosed as a hypothalamic glioma. Also, the pathologic-radiologic-clinical correlation of EVN located in the hypothalamic area may be different from that of EVNs originating from other usual sites.

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Section: Discussionmentioning

confidence: 99%

Hypothalamic Extraventricular Neurocytoma (EVN) in a Pediatric Patient: A Case of EVN Treated with Subtotal Removal Followed by Adjuvant Radiotherapy

Cho

Joo

Kim

et al. 2016

Brain Tumor Res Treat

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“…Olig2 can be used as a diagnostic marker for oligodendroglioma, and positivity for Olig2 suggests oligodendroglioma over CN [9495]. This also argues the rarity of CN cells undergoing glial differentiation.…”

Section: Histopathological Analysis and Molecular Pathogenesismentioning

confidence: 99%

Central Neurocytoma: A Review of Clinical Management and Histopathologic Features

Lee

Bui

Chen

et al. 2016

Brain Tumor Res Treat

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Central neurocytoma (CN) is a rare, benign brain tumor often located in the lateral ventricles. CN may cause obstructive hydrocephalus and manifest as signs of increased intracranial pressure. The goal of treatment for CN is a gross total resection (GTR), which often yields excellent prognosis with a very high rate of tumor control and survival. Adjuvant radiosurgery and radiotherapy may be considered to improve tumor control when GTR cannot be achieved. Chemotherapy is also not considered a primary treatment, but has been used as a salvage therapy. The radiological features of CN are indistinguishable from those of other brain tumors; therefore, many histological markers, such as synaptophysin, can be very useful for diagnosing CNs. Furthermore, the MIB-1 Labeling Index seems to be correlated with the prognosis of CN. We also discuss oncogenes associated with these elusive tumors. Further studies may improve our ability to accurately diagnose CNs and to design the optimal treatment regimens for patients with CNs.

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“…Moreover, a GTR did not significantly decrease the risk of the recurrence being a lower Ki67 (MIB-1) the factor more strongly related to a lower tumor recurrence. Thus, the histopathological examination is crucial both to make the diagnosis (based on some peculiarities, such as the presence of ganglion cell differentiation, lower cell density and immunoreactivity for glial fibrillary acidic protein, synaptophysin, and NeuN, markers for glial and neuronal differentiation[ 6 7 8 ]) and to get the proliferative index (MIB-1). Due to its importance for the prognosis, this data should be routinely investigated (in our analysis it was available only in 10 out of 22 cases [45.45%]).…”

Section: Discussionmentioning

confidence: 99%

Primary intramedullary neurocytoma: Case report and literature analysis

et al. 2015

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Background:Primary intramedullary neurocytoma is extremely rare. Due to its rarity, it is difficult to collect a wide series in a single institution to perform a survival analysis and give indications about prognosis and treatment.Case Description:Here, we report on a case of a 37-year-old woman with primary intramedullary neurocytoma and perform a systematic statistical analysis of cases reported in the literature. Of 21 articles found, 15 studies and the present case (22 patients) were eligible for the analysis. We studied the impact of age, sex, number of involved levels (≤2 vs. >2), entity of resection, postoperative radiotherapy (RT), proliferation index (Ki67) on the neurological outcome of patients, and on the recurrence of the tumor. Comparison of categorical variables was performed by the χ2 statistic. The Kaplan–Meier curves were plotted to calculate the progression-free survival (PFS) of these patients. P < 0.05 was considered as statistically significant. The 1-year PFS was 95.45% and the 2-year PFS was 86.36%. A gross total resection was associated to a worsening of the neurological function with no impact on the tumor recurrence. Adjuvant RT significantly improved the neurological function. A lower Ki67 was strongly associated with a lower tumor recurrence.Conclusions:We think that the goal of the surgery should be to preserve a good neurological function even if a residual tumor has to be left. Ki67 should be always evaluated due to its impact on the prognosis. Although adjuvant RT significantly improved the neurological function, its role in preventing the tumor recurrence is not clearly defined.

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Extraventricular neurocytoma in pediatric populations: A case report and review of the literature

Cited by 22 publications

References 46 publications

Hypothalamic Extraventricular Neurocytoma (EVN) in a Pediatric Patient: A Case of EVN Treated with Subtotal Removal Followed by Adjuvant Radiotherapy

Hypothalamic Extraventricular Neurocytoma (EVN) in a Pediatric Patient: A Case of EVN Treated with Subtotal Removal Followed by Adjuvant Radiotherapy

Central Neurocytoma: A Review of Clinical Management and Histopathologic Features

Primary intramedullary neurocytoma: Case report and literature analysis

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