Dural Melanoma Associated with Ocular Melanosis and Multiple Blue Nevi

Rivers, Jason K.; Bhayana, Shelly; Martinka, Magdalena

doi:10.1007/s10227-001-0004-2

Cited by 12 publications

(4 citation statements)

References 38 publications

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“…A total of 10 arose within nevi of Ota and 3 in nevi of Ito . In addition to these cutaneous melanomas arising in association with nevi of Ota and Ito, over 40 cases of primary melanoma of the uveal tract (choroid, iris and ciliary body), orbital soft tissues, central nervous system, meninges and dura have been reported in association with nevi of Ota . We could not identify reports of malignant transformation of Mongolian spot.…”

Section: Summary Of Cases Of Primary Cutaneous Melanoma Arising In Thmentioning

confidence: 87%

Melanoma arising in a nevus of Ito: novel genetic mutations and a review of the literature on cutaneous malignant transformation of dermal melanocytosis

et al. 2015

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Dermal melanocytosis refers to a spectrum of benign melanocytic proliferations that includes Mongolian spot, nevus of Ota and nevus of Ito. These lesions most commonly occur in persons of Asian or African descent and are often present at birth or develop during childhood. Very rarely, dermal melanocytoses undergo malignant transformation. There have been only 13 reports in the literature of primary cutaneous melanoma arising in dermal melanocytoses. We report a case of a Chinese woman with melanoma arising in a congenital nevus of Ito. We performed targeted next-generation sequencing of the tumor which revealed mutations of GNAQ and BAP1, suggesting that alterations in these two genes led to malignant transformation of the nevus of Ito. We also provide a summary of reports in the literature regarding primary cutaneous melanoma arising in the context of dermal melanocytosis.

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Section: Summary Of Cases Of Primary Cutaneous Melanoma Arising In Thmentioning

confidence: 87%

Melanoma arising in a nevus of Ito: novel genetic mutations and a review of the literature on cutaneous malignant transformation of dermal melanocytosis

et al. 2015

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“…On CT imaging, primary CNS melanomas appear as dense or slightly dense shadows with varying contrast enhancement (Greco Crasto et al, 2001;Lee et al, 2010;Rivers et al, 2001;Somers et al, 2013). However, CT has limitations and cannot accurately visualize all microscopic or diffuse meningeal lesions.…”

Section: M Ag E Pr E S E Ntati O Nmentioning

confidence: 99%

Clinicopathological features, current status, and progress of primary central nervous system melanoma diagnosis and treatment

Guo,

Wei,

Guo

et al. 2023

Pigment Cell Melanoma Res

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Primary central nervous system (CNS) melanoma is an extremely rare condition, with an incidence rate of 0.01 per 100,000 individuals per year. Despite its rarity, the etiology and pathogenesis of this disease are not yet fully understood. Primary CNS melanoma exhibits highly aggressive biological behavior and presents clinically in a distinct manner from other types of melanomas. It can develop at any age, predominantly affecting the meninges as the primary site, with clinical symptoms varying depending on the neoplasm’s location. Due to the lack of specificity in its presentation and the challenging nature of imaging diagnosis, distinguishing primary CNS melanoma from other CNS diseases. The combination of challenges in early detection, heightened tumor aggressiveness, and the obscured location of its origin contribute to an unfavorable prognostic outcome. Furthermore, there has been currently no consensus on a standardized treatment approach for primary CNS melanoma. Despite recent advancements in targeted therapy and immunotherapy for CNS melanoma, patients with primary CNS melanoma have limited treatment options due to their inadequate response to these therapies. Here, we provided a comprehensive summary of the epidemiology, clinical features, molecular pathological manifestations, and available diagnostic and therapeutic approaches of primary CNS melanoma. Additionally, we proposed potential therapeutic strategies for it.

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“…Multiple blue nevi in association with nevus of Ota have rarely been documented. 4 Unlike Mongolian spots and nevus of Ota, blue nevi are typically acquired and more common in whites. They are usually solitary or few, but eruptive lesions have been reported.…”

Section: Commentmentioning

confidence: 99%

Diffuse Dermal Melanocytosis: Follow-up 30 Years Later With Novel Findings of Eruptive Blue Nevi

Diehl¹,

Berk²,

Ney³

et al. 2011

Arch Dermatol

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Dural Melanoma Associated with Ocular Melanosis and Multiple Blue Nevi

Cited by 12 publications

References 38 publications

Melanoma arising in a nevus of Ito: novel genetic mutations and a review of the literature on cutaneous malignant transformation of dermal melanocytosis

Melanoma arising in a nevus of Ito: novel genetic mutations and a review of the literature on cutaneous malignant transformation of dermal melanocytosis

Clinicopathological features, current status, and progress of primary central nervous system melanoma diagnosis and treatment

Diffuse Dermal Melanocytosis: Follow-up 30 Years Later With Novel Findings of Eruptive Blue Nevi

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