Durability of Collagen Injection for Stress Urinary Incontinence in Women Proven by Transvaginal 3-Dimensional Ultrasound

Bacsu, Chasta; Cunningham, Caitlin; Christie, Alana

doi:10.1097/spv.0000000000000094

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…We also studied our MPQ cohort in comparison with our previous long-term report on collagen which had data over 10 years. 8 While collagen had a retention rate of 87% from the first to last 3DUS, our current study has confirmed superior retention rates with MPQ, albeit at a mid-term follow-up.…”

Section: Discussionsupporting

confidence: 68%

“…Our group has extensive experience with 3DUS, as we used this imaging technique to report on the durability of collagen over time in women treated for bothersome SUI who had a well-supported urethra and intrinsic sphincter deficiency (ISD). 8 In that study, we found that despite an overall volume retention rate of 84% at mean follow-up of 43 months, collagen significantly decreased in volume between the first and last follow-up visits.…”

mentioning

confidence: 75%

“…Note: Collagen data from our prior study (see Reference8 ) were analyzed using the same methodology as this study with MPQ, and compared to results from patients receiving MPQ using Kruskal-Wallis tests. Collagen was found to lose considerable volume between injection and first 3DUS, particularly when compared to MPQ.…”

mentioning

confidence: 99%

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Durability of Macroplastique volume and configuration in women with stress urinary incontinence secondary to intrinsic sphincter deficiency: A retrospective review

Carroll

Christie

Foreman

et al. 2020

LUTS

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Objectives: To evaluate the durability of Macroplastique ® (MPQ) volume and configuration in women with stress urinary incontinence (SUI) secondary to intrinsic sphincter deficiency (ISD) using serial three-dimensional ultrasound (3DUS) measurements.Methods: Following Institutional Review Board approval, charts of women with SUI and ISD (defined based on leak point pressure; lateral imaging of urethral support without hypermobility) who underwent MPQ were reviewed from a prospectively maintained database. All had at least two serial transperineal 3DUS measurements with no MPQ or other bulking agent injection between measurements. 3DUS was performed using the Philips IU22 ultrasound system with endovaginal 3D 9-3V end-fire probe typically at 6-8 weeks post-injection and yearly thereafter. The same imaging team blinded to clinical outcomes evaluated volume and configuration (circumferential/symmetric or asymmetric) at each 3DUS.Results: Between 2011 and 2019, 62 of 174 women met study criteria. Those with prior other bulking agent injection or having ≤1 3DUS follow-up were excluded.Seventy-one percent of patients had one injection, while the remainder had two or more (29%). Median time between first and second 3DUS was 12 months. The mean change in MPQ volume between the first and last 3DUS measurement was −0.2 cc (95% CI: −0.5 to 0.004; P = .054). A median of 5.0 cc were injected in each patient.Forty-seven women had symmetric MPQ at first 3DUS, of whom only five (11%) had a follow-up 3DUS showing asymmetric MPQ distribution.Conclusions: At mid-term follow-up, repeat transperineal 3DUS after MPQ injection revealed minimal change in volume and configuration in the urethral wall.

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Section: Discussionsupporting

confidence: 68%

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confidence: 75%

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Durability of Macroplastique volume and configuration in women with stress urinary incontinence secondary to intrinsic sphincter deficiency: A retrospective review

Carroll

Christie

Foreman

et al. 2020

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“…Repeat synthetic MUS's after MUS complications were not favored by women who wished to avoid repeating a procedure that had already failed once and required removal. Furthermore, long‐term data on injectable agents supports better durability than initially reported …”

Section: Discussionsupporting

confidence: 52%

Urodynamics for incontinence after midurethral sling removal

Çoşkun

Lavelle

Alhalabi

et al. 2015

Neurourology and Urodynamics

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“…In this report, as we did for Collagen in the past ( 4 - 6 ), we examined our longer term experience with MPQ using subjective and objective (three-dimensional ultrasound (3DUS)) outcome criteria as well as studied factors that could predict success over time in order to better counsel patients with bothersome incontinence interested in a minimally invasive approach.…”

Section: Introductionmentioning

confidence: 99%

Macroplastique for women with stress urinary incontinence secondary to intrinsic sphincter deficiency

et al. 2019

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Objective: To evaluate the subjective and objective outcomes of Macroplastique® (MPQ) in women with stress urinary incontinence (SUI) secondary to intrinsic sphincter defi ciency (ISD). Materials and Methods: Following Institutional Review Board (IRB) approval, charts of non-neurogenic women with SUI secondary to ISD who underwent MPQ injection and had 6 months minimum follow-up were reviewed from a prospectively maintained database. Patients were divided into 3 groups: Naïve (Group I), Prior Anti-Incontinence Surgery (Group II), and combined Prior Bulking Agent and Anti-Incontinence Surgery (Group III). Data collected included SUI self-report, Urogenital Distress Inventory (UDI-6) Question 3, and VAS Quality of Life (QoL) Questionnaire scores at baseline and in follow-up. Three-dimensional ultrasound (3DUS) evaluated volume/confi guration of MPQ. Success was defi ned after the last MPQ injection as a UDI-6 Question 3 score of 0 (dry) or 1, and no reoperation for SUI. Results: From 2011-2017, 106 of 142 women met study criteria. At a median follow-up of 20 months (mean=26 months; range: 6-71), success rate was 41% for Group I, 40% for Group II, and 65% for Group III (p = 0.22). QoL scores were signifi cantly improved over baseline in all groups. There was no signifi cant difference in clinical outcome between the asymmetrical and symmetrical group on 3DUS. The completely dry rate was highest in Group III at 29%, compared to 4% for Group I and 15% for Group II (p = 0.05). Conclusion: Macroplastique® improved subjective and objective outcome measures for SUI secondary to ISD as both a primary and secondary treatment option in women.

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Durability of Collagen Injection for Stress Urinary Incontinence in Women Proven by Transvaginal 3-Dimensional Ultrasound

Abstract: Although believed to be nondurable, CI was found to be objectively stable over time by transvaginal 3D US in a subset of women with durably improved SUI symptoms.

Cited by 10 publications

References 22 publications

Durability of Macroplastique volume and configuration in women with stress urinary incontinence secondary to intrinsic sphincter deficiency: A retrospective review

Durability of Macroplastique volume and configuration in women with stress urinary incontinence secondary to intrinsic sphincter deficiency: A retrospective review

Urodynamics for incontinence after midurethral sling removal

Macroplastique for women with stress urinary incontinence secondary to intrinsic sphincter deficiency

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