Duplex sonography of retro-orbital and carotid arteries in patients with normal-tension glaucoma

Akcar, Nevbahar; Yıldırım, Nilgün; Adapınar, Baki; Kaya, Tamer İrfan; Ozkan, I. Ragıp

doi:10.1002/jcu.20137

Cited by 7 publications

(5 citation statements)

References 28 publications

(45 reference statements)

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“…Doppler US has been recognized in many papers as an effective tool to assess alteration in these flow dynamics [12, 13, 15]. Most of published studies include healthy patients without glaucoma risk factors as controls and patients with well-established glaucomatous damage as cases, while our population was performed by subjects with risk factors for glaucoma, but without yet established visual field impairment (<−5 dB of MD).…”

Section: Discussionmentioning

confidence: 99%

Role of Color Doppler Imaging in Early Diagnosis and Prediction of Progression in Glaucoma

Jimenez-Aragon

García‐Martín

Larrosa-Lopez

et al. 2013

BioMed Research International

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This longitudinal and prospective study analyzes the ability of orbital blood flow measured by color Doppler imaging (CDI) to predict glaucoma progression in patients with glaucoma risk factors. Patients with normal perimetry but having glaucoma risk factors and patients in the initial phase of glaucoma were prospectively included in the study and divided, after a five-year follow-up, into two groups: “Progression” and “No Progression” based on the changes in the Moorfields regression analysis (MRA) classification of Heidelberg retina tomograph (HRT). An orbital CDI was performed in all patients and the parameters obtained were correlated with changes in HRT. A logistic discrimination function (LDF) was calculated for ophthalmic artery (OA) and central retinal artery (CRA) parameters. Receiver operating characteristics curves (ROC) were used to assess the usefulness of LDFs to predict glaucomatous progression. A total of 71 eyes were included. End-diastolic velocity, time-averaged velocity, and resistive index in the OA and CRA were significantly different (P < 0.05) between the Progression and No Progression groups. The area under the ROC curves calculated for both LDFs was of 0.695 (OA) and 0.624 (CRA). More studies are needed to evaluate the ability of CDI to perform early diagnosis and to predict progression in glaucoma in eyes.

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Section: Discussionmentioning

confidence: 99%

Role of Color Doppler Imaging in Early Diagnosis and Prediction of Progression in Glaucoma

Jimenez-Aragon

García‐Martín

Larrosa-Lopez

et al. 2013

BioMed Research International

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“…CDI has been recognized in many studies as a useful modality to assess alteration in orbital blood flow dynamics. [11][12][13] Authors have analysed flow indices in ophthalmic artery and CRA. The posterior ciliary arteries are small caliber vessels and due to their direction, variable intonation angles are usually required for their analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The CDI imaging was carried out using Philips HD5 scanner using high frequency probe (10)(11)(12). In each eye, Peak systolic Velocity(PSV), End Diastolic Velocity (EDV) and Resistivity index (RI) of OA and CRA.…”

Section: Methodsmentioning

confidence: 99%

Ocular doppler imaging: opening a new window in decoding glaucoma

Senger

Anand²,

Singh³

et al. 2019

Int J Res Med Sci

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Background: In the aetiopathogenesis of multifactorial glaucoma autoregulation of ocular blood flow plays an important role as failure of autoregulation may lead to progression of disease. Aim of this study to understand this better this study was designed to investigate the quantum of these abnormalities and their likely role in pathogenesis and prognosis of primary open angle glaucoma(POAG).Methods: This is a case control study design which involved 67 POAG patients and 67 matched controls. The parameters assessed includes peak systolic velocity(PSV), end diastolic velocity(EDV) and resistive index(RI) of ophthalmic artery(OA) and central retinal artery(CRA) of patients having POAG with age and sex matched healthy subjects. The data obtained was statistically analysed using IBM SPSS 21.Results: The study showed decreased PSV of 31.7 cm/s vs 42.7 cm/s(p=0.0001) and EDV11.7 cm/s vs 19.8 cm/s(p=0.002) with increased RI 0.63 vs 0.53(p=0.000) in OA and PSV of 15.2 cm/s vs 21.4 cm/s(p=0.001) and EDV4.7 cm/s vs 11.7 cm/s(p=0.003) with increased RI 0.69 vs 0.45(p=0.000) in CRA in both eyes in POAG patients as compared to healthy controls.Conclusion: The study has shown the promising application of ocular Doppler in evaluating POAG patients. However, more such studies are needed with larger study sample and on follow up basis for better understanding glaucoma hemodynamics and applicability of ocular Doppler in management of glaucoma.

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“…However, due to several problems, it is difficult to accurately and directly measure the ocular blood flow in real time. Many previous studies have suggested that CDI can assess the changes in ocular hemodynamics [13,[31][32][33]. Although CDI can monitor the ocular blood flow velocity in real time, it indirectly detects the blood flow of large arteries that supply the eyes instead of the blood flow in the ocular microvessels.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Optic Nerve Head Microcirculation Using Optical Coherence Tomography Angiography and the Upstream Macrocirculation Using Color Doppler Imaging in Low-Tension and High-Tension Glaucoma Patients

Hou¹,

Feng²,

Chen³

et al. 2022

Ophthalmic Res

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Introduction: To analyze the optic nerve head (ONH) microcirculation using optical coherence tomography angiography (OCT-A) and the upstream macrocirculation using color Doppler imaging (CDI) in low-tension and high-tension glaucoma (LTG and HTG, respectively). Methods: This cross-sectional study included 67 eyes of 67 HTG patients, 55 eyes of 55 LTG patients, and 42 eyes of 42 healthy controls. We recorded the complete ophthalmological examination, visual fields, retinal nerve fiber layer (RNFL) thickness, ONH vessel density (VD) measured using OCT-A, peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index (RI) measured using CDI. SPSS software was used for data analysis. Data are presented as mean ± standard deviation or median (interquartile range) and compared using t-test or Mann-Whitney U test, as appropriate. Pearson chi-square test or Fisher’s exact test was used for comparisons, as appropriate. Pearson correlation analysis was used to evaluate for the correlations between variables. P < 0.05 was considered statistically significant. Results: The ONH VD and RNFL thickness were considerably lower in glaucomatous eyes than in healthy eyes (both p < 0.001). Compared with the HTG group, the LTG group had lower VD in the peripapillary region (p = 0.027). Compared with the healthy group, the HTG group had lower PSV (p = 0.029 and = 0.023, respectively), lower EDV (p = 0.023 and < 0.001, respectively), and higher RI (p = 0.019 and = 0.006, respectively) of internal carotid artery (ICA) and central retinal artery (CRA). The LTG group had lower PSV (p = 0.015 and < 0.001, respectively) and EDV (p = 0.047 and = 0.001, respectively) of ophthalmic artery (OA) and CRA. The LTG group had lower PSV of CRA than the HTG group (p = 0.034). In glaucomatous eyes, peripapillary VD had a significant association with the mean defect (MD) (p < 0.001) and RNFL thickness (p < 0.001), but not with the other CDI indices (all p > 0.05). Conclusion: The ONH microcirculation and upstream macrocirculation of the large arteries exhibited differences in the blood flow characteristics between the LTG and HTG groups. These differences may improve our understanding of glaucoma. There was no correlation between the characteristics of the ONH microcirculation and the upstream macrocirculation of large vessels in the LTG and HTG groups

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Duplex sonography of retro-orbital and carotid arteries in patients with normal-tension glaucoma

Abstract: In patients with symmetric normal-tension glaucoma, duplex sonography showed an elevated RI in CRA and PCA. The Doppler evaluation of carotid arteries was useful.

Cited by 7 publications

References 28 publications

Role of Color Doppler Imaging in Early Diagnosis and Prediction of Progression in Glaucoma

Role of Color Doppler Imaging in Early Diagnosis and Prediction of Progression in Glaucoma

Ocular doppler imaging: opening a new window in decoding glaucoma

Analysis of the Optic Nerve Head Microcirculation Using Optical Coherence Tomography Angiography and the Upstream Macrocirculation Using Color Doppler Imaging in Low-Tension and High-Tension Glaucoma Patients

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