Dumbbell-like Au-Fe3O4 nanoparticles as label for the preparation of electrochemical immunosensors

A sandwich type immunosensor for ultrasensitive electrochemical quantification of p53 protein based on gold nanoparticles/graphene oxide

“…Similarly, the key to improve the sensitivity is the use of materials that can provide high active surface area, enhancement of electron transfer rate, enhancing the amount of immobilized antibody and applying the appropriate signal amplification procedure [2]. Recently, different materials have been utilized to amplify the response of the immunosensors, including metal nanoparticles such as Pt NPs [14], Au-Fe 3 O 4 NPs [15], carbon NPs [1], graphene nanosheets [16] and carbon nanostructures [17].…”

Synthesis and characterization of l-carnosine coated iron oxide nanoparticles

“…Among these, superparamagnetic iron oxide nanoparticles (SPION) receive increasing attention in different fields of physics, medicine, biology, and materials science due to their multifunctional magnetic, catalytic, biological and conducting properties which make them feasible to find applications in various fields [1]. In clinical area, these particles are used as delivery systems for drugs [2], in medical diagnosis [3][4][5], hyperthermia [6][7][8], cell separation [9,10], etc. Most of these applications require well-dispersed chemically stable nanoparticles having uniform size and shape.…”

“…An important potential application of nano-sized magnetite (NSM) particles is in thermo-genesis, to kill tumor cells under an ac magnetic field [3]. To explore their bio-applications the developments of biocompatible, highly water dispersible and functionalized ferromagnetic nano-materials are crucial, asbiomedical applications require chemically stable, well-dispersed and uniform size particles (5-20 nm diameters) [13,14].…”

Electrochemical immunosensor for prostate-specific antigen using a glassy carbon electrode modified with a nanocomposite containing gold nanoparticles supported with starch-functionalized multi-walled carbon nanotubes

“…As a result, the sensitivity declines when the immunosensor is used to determine a higher concentration of antigen [30]. Compared with some PSA immunosensors reported previously [27,28,37,38], our biosensor is more excellent because of the low detection limit.…”