Ductal carcinoma in situ in a 15-year-old boy with gynaecomastia: a case report

Abstract

Carcinoma in situ of the male breast is rare, especially when associated with bilateral gynaecomastia and during puberty. Only two cases in adults and one during puberty have been described in the literature. We present the case of a 15-year-old boy whom we have been observing for about 2 years for puberal bilateral gynaecomastia, treated with bilateral exeresis of the mammary gland and subsequently re-operated with total bilateral mastectomy because the tissue removed presented atypical features upon histological examination. The authors believe, after a careful review of relevant literature, that this is the second case of intraductal carcinoma in the presence of gynaecomastia described during adolescence.

Incidental finding of synchronous bilateral ductal carcinoma in situ associated with gynecomastia in a 15-year-old obese boy: case report and review of the literature

“…Male breast cancer is usually invasive, with DCIS representing about 5% of MBC cases [5], most DCIS cases being low grade [1]. Pediatric breast cancer comprises less than 0.1% of all breast cancer cases and occurs mainly in girls [11].…”

“…However, its association with MBC remains unclear, studies showing conflicting results [3]. Association between gynecomastia and DCIS has rarely been reported in adults [1,10], and only 3 cases have been described in teenagers [5][6][7].…”

“…Pediatric breast cancer is also rarely encountered, comprising less than 1% of pediatric cancer malignancies [4]. Few cases of pediatric MBC have been described so far [5][6][7][8][9].…”

Is routine pathological evaluation of tissue from gynecomastia necessary? A 15-year retrospective pathological and literature review

“…Obesity was reported in three cases (12,15,19). Serum karyotyping for Kleinfelter syndrome was reported negative postoperatively in six cases (3,12,14,15,18,20). BRCA mutations were reported negative in the three analyzed patients (12,15,17).…”

Ductal Carcinoma In Situ in a 25-Year-Old Man Presenting with Apparent Unilateral Gynecomastia

“…Other sources endorse mammography to recognize mass, because mammography distinguishes between glandular tissue and fat, although it is not universally supported for small and dense male breasts 6 . Mammography for male breast cancer has been reported to be successful, with 92% sensitivity and 91% specificity 17 .…”