Incidental finding of synchronous bilateral ductal carcinoma in situ associated with gynecomastia in a 15-year-old obese boy: case report and review of the literature

Is routine pathological evaluation of tissue from gynecomastia necessary? A 15-year retrospective pathological and literature review

“…Obesity was reported in three cases (12,15,19). Serum karyotyping for Kleinfelter syndrome was reported negative postoperatively in six cases (3,12,14,15,18,20). BRCA mutations were reported negative in the three analyzed patients (12,15,17).…”

“…Serum karyotyping for Kleinfelter syndrome was reported negative postoperatively in six cases (3,12,14,15,18,20). BRCA mutations were reported negative in the three analyzed patients (12,15,17). However, it should be emphasized that these cases represent a select population of incidentally discovered male breast malignancy in routine histopathological examination of gynecomastia tissue samples; thus, they were not expected to present with any of the well-known risk factors for male breast cancer (MBC).…”

“…The most common diagnosis reported was ductal carcinoma in situ (DCIS), detected in 12 patients, and atypical ductal hyperplasia (ADH) in two patients, as summarized chronologically in Table 1 (1,3,6,7,13-21). Obesity was reported in three cases (12,15,19). Serum karyotyping for Kleinfelter syndrome was reported negative postoperatively in six cases (3,12,14,15,18,20).…”

Bilateral, Synchronous Breast Carcinoma in Monozygotic Male Twins with Multi-system Developmental Anomalies: Proposition of a Congenital Etiology

“…Male breast cancer accounts for less than one percent of all breast cancer cases with ductal carcinoma in situ (DCIS) accounting for just 5% of male breast cancer cases (1)(2)(3)(4). Furthermore, bilateral male breast cancer accounts for less than 0.02% of all breast cancer cases (1).…”

ecancermedicalscience

“…Some studies have shown a lower HER-2 expression in men (2–15%) than in women (18–20%), although the data are inconsistent [19, 20]. …”