Ductal carcinoma in a multiple fibroadenoma: Diagnostic inaccuracies

Rao, Shalinee; Latha, PK; Annamalai, Radha; Thanka, J

doi:10.4103/0973-1482.73350

Cited by 9 publications

(16 citation statements)

References 12 publications

(16 reference statements)

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“…1 The detection of malignancy occuring within a fibroadenoma can be difficult. 2,10 Although malignant transformation of a fibroadenoma is very rare, fibroadenoma in a woman with a positive family history may have greater clinical importance than fibroadenoma occuring in a woman with no additional risk factors. 1,3,6,10 Fibroadenomas observed cysts, sclerosing adenosis, epithelial calcifications or papillary apocrine changes.…”

Section: Discussionmentioning

confidence: 99%

“…2 The surgical treatment is depend on the stage and the presence of axillary or distant metastasis. Breast conservative surgery like as lumpectomy or wide local excision with or without axillary lymph node dissection can be selected if the tumor is small or modified radical mastectomy with axillar dissection can be selected for greater tumors or patient's willingness.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] They are the second most common tumours of the breast after carcinoma and the most common benign tumours of the breast in adolescent girls and young women. 1,3 Malignant transformation of fibroadenoma to carcinoma is very rare (equal or less than 0.5%), and the mean age is fifth decade.…”

mentioning

confidence: 99%

“…1,3 Malignant transformation of fibroadenoma to carcinoma is very rare (equal or less than 0.5%), and the mean age is fifth decade. 2,[4][5][6][7] The most common malignant histologic type coexistence with fibroadenoma is lobular carcinoma in situ (66.9%), followed by ductal carcinoma in situ (12.4%), invasive ductal carcinoma (11%), and invasive lobular carcinoma (3.4%). 4 Positive family history, complex fibroadenomas, proliferative disease adjacent fibroadenomas and BRCA mutation are associated with Turkiye Klinikleri J Case Rep 2015;23 (2) fibroadenomas mild increase risk of subsequent breast cancer.…”

mentioning

confidence: 99%

“…2,[4][5][6][7] The most common malignant histologic type coexistence with fibroadenoma is lobular carcinoma in situ (66.9%), followed by ductal carcinoma in situ (12.4%), invasive ductal carcinoma (11%), and invasive lobular carcinoma (3.4%). 4 Positive family history, complex fibroadenomas, proliferative disease adjacent fibroadenomas and BRCA mutation are associated with Turkiye Klinikleri J Case Rep 2015;23 (2) fibroadenomas mild increase risk of subsequent breast cancer. 8 Histopathological examination should be performed routinely to rule out malignancy because of no definitive clinical or radiological criteria for diagnosing carcinoma occuring within fibroadenoma.…”

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confidence: 99%

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Invasive Breast Carcinoma Occuring Within Fibroadenoma: Case Report

Dandin¹,

Karakaş²,

Balta³

et al. 2015

Turkiye Klinikleri J Case Rep

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A AB BS ST TR RA AC CT T Fibroadenomas are the most common benign tumors of the breast. Carcinomas occuring within fibroadenoma are very rare. Fibroadenomas present in approximately 10% of women at autopsy, also occurs 20% of all the benign breast mass and usually identified as circumscribed masses at physical examination or mammography. The most common histologic type is lobular carcinoma in situ, followed by ductal carcinoma in situ, invasive ductal carcinoma and invasive lobular carcinoma. Positive family history, complex fibroadenomas, proliferative disease adjacent fibroadenomas and BRCA mutation are the risk factors for malign transformation within fibroadenomas. Histopathological examination should be performed routinely to rule out malignancy because of no definitive clinical or radiological criteria for diagnosing carcinoma occuring within fibroadenoma. We presented a case of invasive breast carcinoma occuring within fibroadenoma.K Ke ey y W Wo or rd ds s: : Fibroadenoma; carcinoma, ductal; carcinoma, lobular Ö ÖZ ZE ET T Fibroadenomlar memenin en sık benign tümörleridir. Fibroadenomadan kanser gelişimi oldukça nadirdir. Fibroadenoma, genellikle fizik muayene ve mamografide sınırlı kitleler olarak tanımlanıp, kadınların otopsisinde yaklaşık %10 oranında saptanırken tüm iyi huylu meme kitlelerinin % 20'sini oluşturur. En sık görülen histolojik tip lobular karsinoma in situdur, bunu duktal karsinoma in situ, invaziv duktal karsinom, invazif lobüler karsinom takip eder. Pozitif aile öyküsü, karmaşık fibroadenomalar, fibroadenomaya komşu proliferatif hastalık ve BRCA mutasyonu fibroadenomanın malign transformasyonu için risk faktörleridir. Fibroadenomadan karsinom gelişiminin tanısında kesin bir klinik ve radyolojik kriter olmadığından maligniteyi dışlamak için histopatolojik değerlendirme yapılmalıdır. Burada fibroadenomadan gelişen invaziv meme kanserli bir olguyu sunmaktayız.A An na ah ht ta ar r K Ke el li im me el le er r: : Fibroadenom; karsinom, duktal; karsinom, lobüler T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J C Ca as se e R Re ep p 2 20 01 15 5; ;2 23 3( (2 2) ): :1 14 49 9--5 52 2

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Invasive Breast Carcinoma Occuring Within Fibroadenoma: Case Report

Dandin¹,

Karakaş²,

Balta³

et al. 2015

Turkiye Klinikleri J Case Rep

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Fine‐needle aspiration of gray zone lesions of the breast: Fibroadenoma versus ductal carcinoma

Jing

Normolle

Michael

2012

Diagnostic Cytopathology

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While breast lesions have characteristic cytological features, some lesions, particularly adenocarcinoma and fibroadenoma, may present with overlapping features causing erroneous diagnoses. The current study aimed to define significant cytomorphologic features predictive of fibroadenoma and adenocarcinoma, respectively. Further, we intended to evaluate the predictive characteristics for differentiation between gray zone lesions and to identify root causes contributing to misdiagnoses. First, direct smears prepared from 14 histology-confirmed fibroadenomas and 14 adenocarcinomas were reviewed and characteristics of commonly encountered morphologic features were assessed. We then retrospectively and blindly reviewed nine cytohistologic discrepant cases using the significant characteristic as a guideline, in order to assess whether these discrepant cases could be correctly categorized. Morphologic characteristics predictive of fibroadenoma included moderate cellularity, large, folded cellular sheets/aggregates, staghorn projections, smooth and round borders, monolayers, honeycomb arrangement, smaller nuclear size, and background bipolar cells. Predictive characteristics of adenocarcinoma included high cellularity, loose cohesive sheets/aggregates, pointed projections, irregular borders, larger nuclear size, irregular nuclear membrane, prominent nucleoli, and single atypical epithelial cells. Retrospective, blind review correctly re-classified seven out of nine cytohistologic discrepant cases, including five false negative cases and two false positive cases. Root causes contributing to the misdiagnoses were large branching sheets of carcinoma mimicking folded sheets of fibroadenoma; fibroblasts mimicking myoepithelial cells; apocrine cells mimicking carcinoma cells; and not recognizing the loose myxoid matrix presenting as soap bubbles in fibroadenoma. In conclusion, this study identified significant characteristics that can assist in achieving accurate diagnosis in a subpopulation of breast aspirates that present with overlapping features.

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