A comprehensive clinicopathological evaluation of the differential expression of microRNA-331 in breast tumors and its diagnostic significance

Papadopoulos, Emmanuel I.; Papachristopoulou, Georgia; Ardavanis, Alexandros; Scorilas, Andreas

doi:10.1016/j.clinbiochem.2018.07.008

Cited by 10 publications

(9 citation statements)

References 35 publications

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“…Discovery that microRNAs are detected in patients' sera raised the assumption that these serum biomarkers can be used as a less invasive screening or diagnostic tools [8]. miR-331-3p is one of the most upregulated miRNAs that promote proliferation, migration, and invasion of the tumor cells, including HCC [9]. miR-23b-3p was identified as a tumor suppressor that downregulated in different classes of human malignant tumors [10].…”

Section: Introductionmentioning

confidence: 99%

The expression of microRNA-331-3p and microRNA-23b3 in Egyptian patients with early-stage hepatocellular carcinoma in hepatitis C-related liver cirrhosis

Aboelwafa

Ellakany

Gamaleldin

et al. 2021

Egypt Liver Journal

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Background Hepatocellular carcinoma and hepatitis C are strongly associated. The current work aimed to study the expression levels of microRNA-331-3p and microRNA-23b-3p as propable biomarkers for detecting liver cancer (HCC) at its early stages in patients with HCV-related liver cirrhosis. The current prospective study included two hundred participants, divided into three groups: group I, 100 patients with HCV-related liver cirrhosis; group II, 50 HCC patients at early stages; and group III, 50 apparentlyhealthy controls. All patients had routine laboratory workup and ultrasound hepatic assessment. Values of microRNA-331-3p and microRNA-23b-3p were measured by real-time quantitative PCR. Results Levels of miR-331-3p were significantly higher in HCC patients than in cirrhotic patients and controls (p < 0.001), while levels of miR-23b-3p were significantly lower in HCC patients compared to cirrhotics and controls (p < 0.001). ROC curve revealed that miR-23b-3p had 80% sensitivity and 74% specificity, miR-331-3p had 66% sensitivity and 61% specificity, and AFP had 64% sensitivity and 61% specificity of 61% in discrimination between HCC patients from controls. Conclusion Serum miR-23b-3p is a more effective predictor than miR-331-3p and AFP for the development of hepatocellular carcinoma in hepatitis C (HCV)-related cirrhotic patients.

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Section: Introductionmentioning

confidence: 99%

The expression of microRNA-331-3p and microRNA-23b3 in Egyptian patients with early-stage hepatocellular carcinoma in hepatitis C-related liver cirrhosis

Aboelwafa

Ellakany

Gamaleldin

et al. 2021

Egypt Liver Journal

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“…Our results demon- and miR-378. [6][7][8]14,15 Considering that all these microRNAs are highly upregulated in breast cancer, [16][17][18][19][20][21] one can speculate that the decreased expression of ST7L in breast cancer may be an effect of these dysregulated microRNAs. Notably, the expression of ST7L in cancer is also controlled by long noncoding RNAs.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, increasing studies have revealed that decreased expression of ST7L in tumour tissues is due to the effects of dysregulated microRNAs such as miR‐23a/b, miR‐24, miR‐331‐3p and miR‐378 . Considering that all these microRNAs are highly upregulated in breast cancer, one can speculate that the decreased expression of ST7L in breast cancer may be an effect of these dysregulated microRNAs. Notably, the expression of ST7L in cancer is also controlled by long noncoding RNAs …”

Section: Discussionmentioning

confidence: 99%

Suppression of the proliferation and invasion of breast cancer cells by ST7L occurs through inhibition of activation of Wnt/GSK‐3β/β‐catenin signalling

Wang

Sun

Jiang

et al. 2019

Clin Exp Pharma Physio

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Emerging evidence has indicated that suppression of tumorigenicity 7-like (ST7L) is a tumour suppressor in multiple types of cancers. However, the functional involvement of ST7L has not been studied in breast cancer. In the present study, we aimed to investigate the potential biological function of ST7L in breast cancer. Herein, we found that ST7L expression was frequently downregulated in breast cancer cell lines.

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“…They observed that miR-331 significantly correlated with malignant breast tumors compared to their benign counterparts. Therefore, miR-331 could be considered a good prognostic marker for BC [ 118 ]. Kim et al investigated the prognostic value of five microRNAs (miR-134, miR-125b-5P, miRNA-30a, miR-10a-5p, and miR-222) in HR-positive BC during tamoxifen treatment in 176 tumor tissues from HR+ patients receiving tamoxifen through qRT-PCR.…”

Section: Clinical Value Of Non-coding Rnas In Bcmentioning

confidence: 99%

Predictive and Prognostic Value of Non-Coding RNA in Breast Cancer

Sobhani

Chahwan

Roudi

et al. 2022

Cancers

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For decades since the central dogma, cancer biology research has been focusing on the involvement of genes encoding proteins. It has been not until more recent times that a new molecular class has been discovered, named non-coding RNA (ncRNA), which has been shown to play crucial roles in shaping the activity of cells. An extraordinary number of studies has shown that ncRNAs represent an extensive and prevalent group of RNAs, including both oncogenic or tumor suppressive molecules. Henceforth, various clinical trials involving ncRNAs as extraordinary biomarkers or therapies have started to emerge. In this review, we will focus on the prognostic and diagnostic role of ncRNAs for breast cancer.

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A comprehensive clinicopathological evaluation of the differential expression of microRNA-331 in breast tumors and its diagnostic significance

Cited by 10 publications

References 35 publications

The expression of microRNA-331-3p and microRNA-23b3 in Egyptian patients with early-stage hepatocellular carcinoma in hepatitis C-related liver cirrhosis

The expression of microRNA-331-3p and microRNA-23b3 in Egyptian patients with early-stage hepatocellular carcinoma in hepatitis C-related liver cirrhosis

Suppression of the proliferation and invasion of breast cancer cells by ST7L occurs through inhibition of activation of Wnt/GSK‐3β/β‐catenin signalling

Predictive and Prognostic Value of Non-Coding RNA in Breast Cancer

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