Duck hepatitis B virus and liver diseases

Omata, Masao; Uchiumi, Katsuo; Ito, Yoshimi; Yokosuka, Osamu; Mori, Junko; Terao, Kiyoshi; Ye, Wei‐Fa; O'Connell, Anna P.; London, W. T.; Okuda, Kunio

doi:10.1016/0016-5085(83)90309-8

Cited by 86 publications

(18 citation statements)

References 10 publications

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“…Primary DHBV infection can also induce liver injury (68), though the long-term consequences of this are less clear. Hepatocellular carcinoma is known to occur in duck flocks in some parts of the world (69,70) , but data on concomitant viral infection is lacking and the fr equent presence of dietary aflatoxin, a known hepatic carcinogen, presents additional uncertainties. However, one well-characterized example of PHC arising in a DHBV carrier has been reported (69).…”

Section: Animal Hepadnavirusesmentioning

confidence: 99%

The Molecular Biology of the Hepatitis B Viruses

Ganem¹,

Varmus²

1987

Annu. Rev. Biochem.

1,013

591

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Section: Animal Hepadnavirusesmentioning

confidence: 99%

The Molecular Biology of the Hepatitis B Viruses

Ganem¹,

Varmus²

1987

Annu. Rev. Biochem.

1,013

591

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“…In woodchucks, persistent WHV infection is associated with acute and chronic inflammatory changes (that is, chronic hepatitis), but not with c i r r h o s i~.~~*~~ A large proportion of persistently infected woodchucks develop H C C .~~ Liver disease in DHBV-infected ducks has been reported only from a single area in China. 68 Colonies of infected Pekin ducks from Japan and the United States have not shown histologic evidence of liver disease. A single DHBV-infected animal is reported to have developed H C C ,~~ but the relationship of this tumor to DHBV infection is not yet established.…”

Section: Other Hepadna Virusesmentioning

confidence: 98%

Hepatitis B Virus and Hepatocellular Carcinoma: Molecular Biology and Mechanistic Considerations

Sherman¹,

Shafritz²

1984

Semin Liver Dis

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The question of whether HBV causes HCC has to date best been answered by epidemiologic studies, in particular prospective analysis such as the ongoing study in Taiwan. The mechanism whereby HBV may cause HCC by genetic or epigenetic means, acting alone or in concert with other agents, is still moot . To date, studies of HBV gene expression have not shown the presence of a transforming gene or an oncogene associated with this virus. The finding of integrated HBV DNA in most HCC of carriers is highly suggestive of a causal role of the virus in the pathogenesis of neoplasia. In order to be more certain, it will be necessary to show that expression of integrated HBV genes or of cellular genes, as a result of HBV infection, causes neoplastic transformation of cells. Failure to date to demonstrate that HBV DNA induces neoplastic transformation of eukaryotic cells in culture may be simply due to an inadequate experimental model. The majority of these experiments have used fibroblasts or monkey kidney cells as the recipient cell, whereas cultured human hepatocytes might be more suitable. Whatever role HBV eventually is shown to have in the pathogenesis of HCC, molecular biologic techniques will have in great measure contributed to that knowledge. The use of these powerful new methods will permit studies of the replication of HBV and possible elucidation of how this virus affects the hepatocyte during persistent infection and will in time lead to a better understanding of cell and molecular events leading to development of hepatic malignancy.

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“…Chronic courses of hepadnavirus infections also occur in ducks, squirrels, and NHPs (Table 2). 30,96,112,113,[116][117][118]153 Whether chronic hepadnavirus infections occur in bats is unclear. 30 Among non-human hepaciviruses, studies reporting chronic infections are scarce.…”

Section: Chronic Courses Of Infection Occur In Diverse Hepatitis Virumentioning

confidence: 99%