Dual T<sub>1</sub>/T<sub>2</sub> MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles

Borges, Marcio; Yu, Shujuan; Laromaine, Anna; Roig, Anna; Suárez-García, Salvio; Lorenzo, Júlia; Ruiz‐Molina, Daniel; Novio, Fernando

doi:10.1039/c5ra17661a

Cited by 37 publications

(23 citation statements)

References 64 publications

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“…The iron-based NCPs exhibit a signal enhancement in a concentration-dependent manner and a T 1 positive contrast of r 1 = 0. 49 However, they present a high T 2 negative contrast, which make these nanoparticles a very promising T 2 contrast agent with r 2 relaxivities nearly 25 times higher than Gd-DTPA.…”

mentioning

confidence: 99%

Versatile iron–catechol-based nanoscale coordination polymers with antiretroviral ligand functionalization and their use as efficient carriers in HIV/AIDS therapy

et al. 2019

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mentioning

confidence: 99%

Versatile iron–catechol-based nanoscale coordination polymers with antiretroviral ligand functionalization and their use as efficient carriers in HIV/AIDS therapy

et al. 2019

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“…Os materiais híbridos constituem uma alternativa para a produção de novos materiais multifuncionais, com uma larga faixa de aplicações. 68,71 Normalmente, as características desejadas não são encontradas em um único constituinte e a combinação adequada dos componentes tem levado à formação de materiais que apresentam propriedades complementares, que não são encontradas em uma única substância. 68,71 Dentre das diversas aplicações desses materiais híbridos, podemos citar o uso deles como ACs, os estudos ainda são muito recentes, mas já mostram serem promissores.…”

Section: 5materias Híbridosunclassified

Contrast Agents for Magnetic Resonance Imaging: A Review

Gonçalves¹,

Ramalho²

2017

Rev. Virtual Quim.

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Abstract:The Magnetic Resonance Imaging (MRI) is a noninvasive technique based on the magnetic properties of the 1 H atoms. Currently, about 30% of MRI exams use paramagnetic compounds, which are defined as contrast agents (CAs), able to reduce the relaxation times (T 1 and T 2 ) of hydrogen atoms from water molecules. In this review, we show the main compounds employed as CAs. Among these, Gd 3+ complexes are frequently used, but problems related to their high toxicity and relaxivities, promoting the development of new ACs, such as iron oxides, hybrid compounds as well as Mn 2+ and Ni 2+ complexes, which are less toxic and more effective.Keywords: Contrast agents; MRI; paramagnetic compounds. ResumoA Imagem por Ressonância Magnética (IRM) é uma técnica não invasiva baseada nas propriedades magnéticas dos átomos de 1H. Atualmente, cerca de 30% dos exames de IRM utilizam compostos paramagnéticos capazes de reduzir os tempos de relaxação (T 1 e T 2 ) dos átomos de hidrogênio a partir das moléculas de água, que são definidos como agentes de contrastes (ACs). Nesta revisão, mostramos os principais compostos utilizados como ACs. Entre eles, complexo de Gd3+ são frequentemente utilizados, mas os problemas relacionados com a sua elevada toxicidade e relaxatividade, promoveu o desenvolvimento de novos ACs, tais como óxidos de ferro, compostos híbridos, bem como complexos de Mn2+ e Ni2+ que são menos tóxicos e mais eficazes.

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“…38 Thus, a low r 2 /r 1 ratio (<5) is considered to be ideal for positive MRI contrast agents. 39 As is observed in Fig. 6, the r 1 value obtained for the Eu(5%):NaGd (MoO 4 ) 2 @citrate sample at 1.5 T was very high (8.96 mM −1 s −1 ), whereas r 2 was 5.03 mM −1 s −1 , resulting in an r 2 /r 1 ratio of 1.78, which is among the lowest values ever reported for Gd containing nanoparticles 5,16,40 making our system appropriate as a positive MRI contrast agent.…”

Section: Ln-doped Nagd(moo 4 ) 2 Nanoparticlesmentioning

confidence: 99%

Multifunctional Eu-doped NaGd(MoO₄)₂ nanoparticles functionalized with poly(l-lysine) for optical and MRI imaging

et al. 2016

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A method for the synthesis of non-aggregated and highly uniform Eu doped NaGd(MoO) nanoparticles is reported for the first time. The obtained particles present tetragonal structure, ellipsoidal shape and their size can be varied by adjusting the experimental synthesis parameters. These nanoparticles, which were coated with citrate anions and functionalised with PLL, have also been developed in order to improve their colloidal stability in physiological medium (2-(N-morpholino)ethanesulfonic acid, MES). A study of the luminescent dynamics of the samples as a function of the Eu doping level has been conducted in order to find the optimum nanophosphors, whose magnetic relaxivity and cell viability have also been evaluated for the first time for this system, in order to assess their suitability as multifunctional probes for optical (in vitro) and magnetic bioimaging applications.

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Dual T₁/T₂ MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles

Abstract: A novel dual T1/T21H-MRI contrast agent based on the encapsulation of super-paramagnetic iron oxide nanoparticles (SPIONs) with an iron coordination polymer is proposed.

Cited by 37 publications

References 64 publications

Versatile iron–catechol-based nanoscale coordination polymers with antiretroviral ligand functionalization and their use as efficient carriers in HIV/AIDS therapy

Versatile iron–catechol-based nanoscale coordination polymers with antiretroviral ligand functionalization and their use as efficient carriers in HIV/AIDS therapy

Contrast Agents for Magnetic Resonance Imaging: A Review

Multifunctional Eu-doped NaGd(MoO₄)₂ nanoparticles functionalized with poly(l-lysine) for optical and MRI imaging

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Dual T1/T2 MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles

Abstract: A novel dual T1/T21H-MRI contrast agent based on the encapsulation of super-paramagnetic iron oxide nanoparticles (SPIONs) with an iron coordination polymer is proposed.

Cited by 37 publications

References 64 publications

Versatile iron–catechol-based nanoscale coordination polymers with antiretroviral ligand functionalization and their use as efficient carriers in HIV/AIDS therapy

Versatile iron–catechol-based nanoscale coordination polymers with antiretroviral ligand functionalization and their use as efficient carriers in HIV/AIDS therapy

Contrast Agents for Magnetic Resonance Imaging: A Review

Multifunctional Eu-doped NaGd(MoO4)2 nanoparticles functionalized with poly(l-lysine) for optical and MRI imaging

Contact Info

Product

Resources

About

Dual T₁/T₂ MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles

Multifunctional Eu-doped NaGd(MoO₄)₂ nanoparticles functionalized with poly(l-lysine) for optical and MRI imaging