Versatile iron–catechol-based nanoscale coordination polymers with antiretroviral ligand functionalization and their use as efficient carriers in HIV/AIDS therapy

Solórzano, Rubén; Tort, Olivia; García-Pardo, Javier; Escribà, Tuixent; Lorenzo, Júlia; Arnedo, Mireia; Ruiz‐Molina, Daniel; Alibés, Ramón; Busquè, Félix; Novio, Fernando

doi:10.1039/c8bm01221k

Cited by 27 publications

(20 citation statements)

References 65 publications

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“…These polymers offered long-lasting drug release and improved colloidal stabilities, as well as enhanced cellular uptake (ie, an increase of up to 50fold). 144 The proliposomes increased the MRT of adefovir dipivoxil in the liver by approximately 3-fold compared with the adefovir suspension. 145 The poly (lactic acid)-poly (ethylene glycol)-ligand NPs targeted the intestinal transporter PepT1 and increased permeability by 2.7-fold compared with free acyclovir.…”

Section: Nanotechnology To Improve Pharmacokinetics Of Avds Delivery System To Improve Pharmacokineticsmentioning

confidence: 95%

Antiviral Drug Delivery System for Enhanced Bioactivity, Better Metabolism and Pharmacokinetic Characteristics

Chen¹,

Wang²,

Song³

et al. 2021

IJN

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Antiviral drugs (AvDs) are the primary resource in the global battle against viruses, including the recent fight against corona virus disease 2019 . Most AvDs require multiple medications, and their use frequently leads to drug resistance, since they have poor oral bioavailability and low efficacy due to their low solubility/low permeability. Characterizing the in vivo metabolism and pharmacokinetic characteristics of AvDs may help to solve the problems associated with AvDs and enhance their efficacy. In this review of AvDs, we systematically investigated their structure-based metabolic reactions and related enzymes, their cellular pharmacology, and the effects of metabolism on AvD pharmacodynamics and pharmacokinetics. We further assessed how delivery systems achieve better metabolism and pharmacology of AvDs. This review suggests that suitable nanosystems may help to achieve better pharmacological activity and pharmacokinetic behavior of AvDs by altering drug metabolism through the utilization of advanced nanotechnology and appropriate administration routes. Notably, such AvDs as ribavirin, remdesivir, favipiravir, chloroquine, lopinavir and ritonavir have been confirmed to bind to the severe acute respiratory syndrome-like coronavirus (SARS-CoV-2) receptor and thus may represent anti-COVID-19 treatments. Elucidating the metabolic and pharmacokinetic characteristics of AvDs may help pharmacologists to identify new formulations with high bioavailability and efficacy and help physicians to better treat virus-related diseases, including COVID-19.

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Section: Nanotechnology To Improve Pharmacokinetics Of Avds Delivery System To Improve Pharmacokineticsmentioning

confidence: 95%

Antiviral Drug Delivery System for Enhanced Bioactivity, Better Metabolism and Pharmacokinetic Characteristics

Chen¹,

Wang²,

Song³

et al. 2021

IJN

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show abstract

“…In particular, catechol–Fe(III)–catechol crosslinking led to self‐healing hydrogels 108. Subsequently, numerous hydrogels using catechol/Fe(III) binding109 as well as force measurements of bis‐catechol‐Fe 3+ (200 pN) and tris‐catechol‐Fe 3+ (100 pN) at the single molecule level110 were reported. In contrast to the use of Fe(III) in a catechol system, the collaboration team of Lee and Lee found that the gelation kinetics of catechol‐conjugated polymers dramatically differs when using vanadium ions.…”

Section: Studies By Kaist Faculty Membersmentioning

confidence: 99%

Polydopamine and Its Derivative Surface Chemistry in Material Science: A Focused Review for Studies at KAIST

2020

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Polydopamine coating, the first material‐independent surface chemistry, and its related methods significantly influence virtually all areas of material science and engineering. Functionalized surfaces of metal oxides, synthetic polymers, noble metals, and carbon materials by polydopamine and its related derivatives exhibit a variety of properties for cell culture, microfluidics, energy storage devices, superwettability, artificial photosynthesis, encapsulation, drug delivery, and numerous others. Unlike other articles, this review particularly focuses on the development of material science utilizing polydopamine and its derivatives coatings at the Korea Advanced Institute of Science and Technology for a decade. Herein, it is demonstrated how material‐independent coating methods provide solutions for challenging problems existed in many interdisciplinary areas in bio‐, energy‐, and nanomaterial science by collaborations and independent research.

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“…An example of this approach is the work done by Gref et al who studied the use of a MOF obtained by reacting Fe(III) and trimesic acid as an anti-HIV AZT-TP drug delivery system [63]. Other examples are the work of Keskin and Kızılel about the antiviral drug delivery uses of three different MOFs developed by reacting Zn 4 O(CO) 2 and three different dicarboxylate linkers [64] and the work Novio et al about the uses of iron-catechol-based MOFs as antiviral drugs delivery systems [65].…”

Section: Supporting Rolementioning

confidence: 99%

Polymers in the Medical Antiviral Front-Line

2020

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Antiviral polymers are part of a major campaign led by the scientific community in recent years. Facing this most demanding of campaigns, two main approaches have been undertaken by scientists. First, the classic approach involves the development of relatively small molecules having antiviral properties to serve as drugs. The other approach involves searching for polymers with antiviral properties to be used as prescription medications or viral spread prevention measures. This second approach took two distinct directions. The first, using polymers as antiviral drug-delivery systems, taking advantage of their biodegradable properties. The second, using polymers with antiviral properties for on-contact virus elimination, which will be the focus of this review. Anti-viral polymers are obtained by either the addition of small antiviral molecules (such as metal ions) to obtain ion-containing polymers with antiviral properties or the use of polymers composed of an organic backbone and electrically charged moieties like polyanions, such as carboxylate containing polymers, or polycations such as quaternary ammonium containing polymers. Other approaches include moieties hybridized by sulphates, carboxylic acids, or amines and/or combining repeating units with a similar chemical structure to common antiviral drugs. Furthermore, elevated temperatures appear to increase the anti-viral effect of ions and other functional moieties.

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Versatile iron–catechol-based nanoscale coordination polymers with antiretroviral ligand functionalization and their use as efficient carriers in HIV/AIDS therapy

Abstract: Iron-based nanoscale coordination polymers as novel drug delivery systems for efficient HIV/AIDS therapy.

Cited by 27 publications

References 65 publications

Antiviral Drug Delivery System for Enhanced Bioactivity, Better Metabolism and Pharmacokinetic Characteristics

Antiviral Drug Delivery System for Enhanced Bioactivity, Better Metabolism and Pharmacokinetic Characteristics

Polydopamine and Its Derivative Surface Chemistry in Material Science: A Focused Review for Studies at KAIST

Polymers in the Medical Antiviral Front-Line

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