Dual Stimuli-Triggered Nanogels in Response to Temperature and pH Changes for Controlled Drug Release

Kim, Yun Kyoung; Kim, Eun-Joong; Lim, Jae Hyun; Cho, Heui Kyoung; Hong, Woo Jin; Jeon, Hyang; Chung, Bong Geun

doi:10.1186/s11671-019-2909-y

Cited by 66 publications

(43 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1b). Compared to our previous work [15], the LCST of Dox@PNIPAM-ppy-FA was slightly decreased than that of PNIPAM-AAc (42 °C). This difference could be caused by the reduced carboxyl groups in PNIPAM-AAc owing to polymerized ppy and conjugated cancer targeting ligand [28].Subsequently, we monitored the change of particle size depending on the temperature in Fig.…”

Section: Synthesis and Characterization Of Nir And Thermos-responsivecontrasting

confidence: 91%

“…The thermo-responsive PNIPAM copolymerized with AAc nanoparticle was synthesized according to previous report [15]. 1.13 g of NIPAM monomer, 0.077 g of MBA and 0.136 g of AAc were dissolved in 100 mL deionized water and added in a 250-mL three-neck roundbottom flask.…”

Section: Synthesis Of Ppy-decorated Pnipam-aac Nanoparticlementioning

confidence: 99%

“…For the generation of thermo-responsive PNIPAM-based nanocomposites, PNIPAM-AAc nanoparticles were fabricated by a radical polymerization method [15]. To control LCST via NIR laser irradiation, ppy was covered by polymerization reaction in as-prepared PNIAPM-AAc.…”

Section: Synthesis and Characterization Of Nir And Thermos-responsivementioning

confidence: 99%

“…However, due to the spontaneous drug release at body temperature, PNIPAMbased nanocarrier is not sufficient to use in advanced DDS. To surmount this, the previous studies added the organic acids (e.g., vinyl acetic, acrylic, and allyl acetic acid) in synthetic process of PNIPAM, resulting in the reduced side effects by the continuous drug release [15].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, since nanocomposites did not have a targeting moiety against specific cancer cells, it could cause the serious side effects to other organs or normal tissues. In our previous report, we developed a bi-directional controlled release system using the thermo-and pH-sensitive properties of PNIPAM [15]. PNIPAM nanogels were co-polymerized with acrylic acid (AAc) contents for efficient control of LCST.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Near-Infrared Light-Triggered Thermo-responsive Poly(N-Isopropylacrylamide)-Pyrrole Nanocomposites for Chemo-photothermal Cancer Therapy

et al. 2020

Self Cite

View full text Add to dashboard Cite

The combination therapy based on multifunctional nanocomposites has been considered as a promising approach to improve cancer therapeutic efficacy. Herein, we report targeted multi-functional poly(N-isopropylacrylamide) (PNIPAM)-based nanocomposites for synergistic chemo-photothermal therapy toward breast cancer cells. To increase the transition temperature, acrylic acid (AAc) was added in synthetic process of PNIPAM, showing that the intrinsic lower critical solution temperature was changed to 42 °C . To generate the photothermal effect under near-infrared (NIR) laser irradiation (808 nm), polypyrrole (ppy) nanoparticles were uniformly decorated in PNIPAM-AAc. Folic acid (FA), as a cancer targeting ligand, was successfully conjugated on the surplus carboxyl groups in PNIPAM network. The drug release of PNIPAM-ppy-FA nanocomposites was efficiently triggered in response to the temperature change by NIR laser irradiation. We also confirmed that PNIPAM-ppy-FA was internalized to MDA-MB-231 breast cancer cells by folate-receptor-mediated endocytosis and significantly enhanced cancer therapeutic efficacy with combination treatment of chemo-photothermal effects. Therefore, our work encourages further exploration of multi-functional nanocarrier agents for synergistic therapeutic approaches to different types of cancer cells.

show abstract

Section: Synthesis and Characterization Of Nir And Thermos-responsivecontrasting

confidence: 91%

Section: Synthesis Of Ppy-decorated Pnipam-aac Nanoparticlementioning

confidence: 99%

Section: Synthesis and Characterization Of Nir And Thermos-responsivementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Near-Infrared Light-Triggered Thermo-responsive Poly(N-Isopropylacrylamide)-Pyrrole Nanocomposites for Chemo-photothermal Cancer Therapy

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

Tuning the Volume Phase Transition Temperature of Microgels by Light

Jelken

Jung

Lomadze

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

Temperature‐responsive microgels find widespread applications as soft materials for designing actuators in microfluidic systems, as carriers for drug delivery or catalysts, as functional coatings, and as adaptable sensors. The key property is their volume phase transition temperature, which allows for thermally induced reversible swelling/deswelling. It is determined by the gel's chemical structure as well as network topology and cannot be varied easily within one system. Here a paradigm change of this notion by facilitating a light‐triggered reversible switching of the microgel volume in the range between 32 and 82 °C is suggested. Photo‐sensitivity is introduced by photosensitive azobenzene containing surfactant, which forms a complex with microgels consisting of poly(N‐isopropylacrylamide‐co‐acrylic acid) (PNIPAM‐AAc) chains when assuming a hydrophobic trans‐state, and prefers to leave the gel matrix in its cis‐state. Using a similar strategy, it is demonstrated that at a fixed temperature, for example, 37 °C, one can reversibly change the microgel radius by a factor of 3 (7–21 µm) by irradiating either with UV (collapsed state) or green light (swollen state). It is envisaged that the possibility to deploy a swift external means of adapting the swelling behavior of microgels may impact and redefine the latter's application across all fields.

show abstract

Tailored Beta‐Lapachone Nanomedicines for Cancer‐Specific Therapy

Feng

Guo

Wang

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Nanotechnology shows the power to improve efficacy and reduce the adverse effects of anticancer agents. As a quinone‐containing compound, beta‐lapachone (LAP) is widely employed for targeted anticancer therapy under hypoxia. The principal mechanism of LAP‐mediated cytotoxicity is believed due to the continuous generation of reactive oxygen species with the aid of NAD(P)H: quinone oxidoreductase 1 (NQO1). The cancer selectivity of LAP relies on the difference between NQO1 expression in tumors and that in healthy organs. Despite this, the clinical translation of LAP faces the problem of narrow therapeutic window that is challenging for dose regimen design. Herein, the multifaceted anticancer mechanism of LAP is briefly introduced, the advance of nanocarriers for LAP delivery is reviewed, and the combinational delivery approaches to enhance LAP potency in recent years are summarized. The mechanisms by which nanosystems boost LAP efficacy, including tumor targeting, cellular uptake enhancement, controlled cargo release, enhanced Fenton or Fenton‐like reaction, and multidrug synergism, are also presented. The problems of LAP anticancer nanomedicines and the prospective solutions are discussed. The current review may help to unlock the potential of cancer‐specific LAP therapy and speed up its clinical translation.

show abstract

Dual Stimuli-Triggered Nanogels in Response to Temperature and pH Changes for Controlled Drug Release

Cited by 66 publications

References 37 publications

Near-Infrared Light-Triggered Thermo-responsive Poly(N-Isopropylacrylamide)-Pyrrole Nanocomposites for Chemo-photothermal Cancer Therapy

Near-Infrared Light-Triggered Thermo-responsive Poly(N-Isopropylacrylamide)-Pyrrole Nanocomposites for Chemo-photothermal Cancer Therapy

Tuning the Volume Phase Transition Temperature of Microgels by Light

Tailored Beta‐Lapachone Nanomedicines for Cancer‐Specific Therapy

Contact Info

Product

Resources

About