Dual-stimuli responsive PNiPAM microgel achieved via layer-by-layer assembly: Magnetic and thermoresponsive

Wong, John E.; Gaharwar, Akhilesh K.; Müller-Schulte, Detlef; Bahadur, D.; Richtering, Walter

doi:10.1016/j.jcis.2008.05.024

Cited by 133 publications

(97 citation statements)

References 40 publications

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“…These magnetic hydrogels have a reversible behavior and therefore can re-acquire the initial conformation when the AMF is off [14]. Several groups have thus developed remotely triggered drug delivery systems with micro-gels [15,16], injectable hydrogels [17] and solid patches that can release drug when exposed to an AMF [14,18]. Others have proposed hydrogels that potentially can target and heat a tumor for hyperthermia treatment [19].…”

Section: Introductionmentioning

confidence: 99%

Dynamic and biocompatible thermo-responsive magnetic hydrogels that respond to an alternating magnetic field

Crippa

Moore

Mortato

et al. 2017

Journal of Magnetism and Magnetic Materials

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Magnetic thermo-responsive hydrogels are a new class of materials that have recently attracted interest in biomedicine due to their ability to change phase upon magnetic stimulation. They have been used for drug release, magnetic hyperthermia treatment, and can potentially be engineered as stimuli-responsive substrates for cell mechanobiology. In this regard, we propose a series of magnetic thermo-responsive nanocomposite substrates that undergo cyclical swelling and de-swelling phases when actuated by an alternating magnetic field in aqueous environment. The synthetized substrates are obtained with a facile and reproducible method from poly-N-isopropylacrylamide and superparamagnetic iron oxide nanoparticles. Their conformation and the temperature-related, magnetic, and biological behaviors were characterized via scanning electron microscopy, swelling ratio analysis, vibrating sample magnetometry, alternating magnetic field stimulation and indirect viability assays. The nanocomposites showed no cytotoxicity with fibroblast cells, and exhibited swelling/deswelling behavior near physiological temperatures (around 34°C). Therefore these magnetic thermo-responsive hydrogels are promising materials as stimuli-responsive substrates allowing the study of cell-behavior by changing the hydrogel properties in situ.

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Section: Introductionmentioning

confidence: 99%

Dynamic and biocompatible thermo-responsive magnetic hydrogels that respond to an alternating magnetic field

Crippa

Moore

Mortato

et al. 2017

Journal of Magnetism and Magnetic Materials

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“…[8] To overcome this problem, silver NPs are usually loaded or dispersed in a solid matrix, such as polymeric matrices e.g. hydrogels, [9] polyelectrolyte brushes, [10] and dendrimers, [11] or inorganic oxides e.g. silica, [12] alumina, [13] titania [14] and zeolite.…”

Section: Introductionmentioning

confidence: 99%

Ag‐nanoparticle embedded p(AA) hydrogel as an efficient green heterogeneous Nano‐catalyst for oxidation and reduction of organic compounds

Ghorbanloo

Heydari

Yahiro

2017

Applied Organom Chemis

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P(AA)‐Ag heterogeneous catalyst system comprised of Ag nanoparticles embedded within hydrogel matrices has been described for the selective aerobic oxidation of alcohols and reduction of nitro phenols in water. P(AA)‐Ag nanocomposite was characterized by Fourier transform infrared (FT‐IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), X‐Ray photoelectron spectroscopy (XPS) and inductively coupled plasma atomic emission spectrometer (ICP). Catalytic activity of p(AA)‐Ag catalyst was investigated in the aerobic oxidation of primary alcohols and reduction of nitro compounds by emphasizing the effect of different parameters such as temperature, catalyst amount, substituent effect, etc. The catalyst was easily recovered from the reaction medium and it could be re‐used for other three runs without significant loss of activity.

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“…This holds promise for future clinical applications in that this system can target deep into the tissue, enables a non-invasive and remotely controlled drug release and can be combined with hyperthermia treatment and magnetic resonance imaging system [10][11][12] . Such platforms include: (1) MNPs/pNIPAM hybrid microgel particles [13][14][15] and (2) macroscopic hydrogel scaffolds incorporating immobilized MNPs [16][17][18] . The pNIPAM-based microgel platforms demonstrated a finely-tunable volume phase transition responsiveness to magneto-thermal stimuli.…”

Section: Introductionmentioning

confidence: 99%

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Sung

Shaffer

Sittek

et al. 2016

JoVE

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Magnetically-responsive nano/micro-engineered biomaterials that enable a tightly controlled, on-demand drug delivery have been developed as new types of smart soft devices for biomedical applications. Although a number of magnetically-responsive drug delivery systems have demonstrated efficacies through either in vitro proof of concept studies or in vivo preclinical applications, their use in clinical settings is still limited by their insufficient biocompatibility or biodegradability. Additionally, many of the existing platforms rely on sophisticated techniques for their fabrications. We recently demonstrated the fabrication of biodegradable, gelatin-based thermo-responsive microgel by physically entrapping poly(N-isopropylacrylamide-co-acrylamide) chains as a minor component within a three-dimensional gelatin network. In this study, we present a facile method to fabricate a biodegradable drug release platform that enables a magneto-thermally triggered drug release. This was achieved by incorporating superparamagnetic iron oxide nanoparticles and thermo-responsive polymers within gelatin-based colloidal microgels, in conjunction with an alternating magnetic field application system. Video LinkThe video component of this article can be found at

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Dual-stimuli responsive PNiPAM microgel achieved via layer-by-layer assembly: Magnetic and thermoresponsive

Cited by 133 publications

References 40 publications

Dynamic and biocompatible thermo-responsive magnetic hydrogels that respond to an alternating magnetic field

Dynamic and biocompatible thermo-responsive magnetic hydrogels that respond to an alternating magnetic field

Ag‐nanoparticle embedded p(AA) hydrogel as an efficient green heterogeneous Nano‐catalyst for oxidation and reduction of organic compounds

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

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