Dual-Stimuli-Responsive Microparticles

Sokolovskaya, Ekaterina; Rahmani, Sahar; Misra, Asish C.; Bräse, Stefan; Lahann, Joerg

doi:10.1021/acsami.5b01592

Cited by 45 publications

(54 citation statements)

References 44 publications

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“…21 In the past decade, the fabrication of multicompartmental fibers and particles with two to seven different compartments and with various shapes via EHD co-jetting has been well-established. [22][23][24][25][26] Additionally, within these systems, the incorporation of water-based and organicbased polymers, 25,[27][28][29] functional polymers for the creation of specific targeting and stealth patches on the surface of the particles, 30,31 stimuliresponsive polymers for on-demand therapeutic release kinetics, [32][33][34] small molecule-based therapeutics, [33][34][35] DNA-based therapeutics, 36 protein-based therapeutics, 35 and imaging agents 22 have been explored. Furthermore, the interaction of such systems with various cell types, 34,[36][37][38][39][40][41] their biodistribution in vivo, 42 and their functionality as carriers for dual therapeutic delivery to the cochlea 35,43 have demonstrated that multifunctional systems fabricated based on EHD co-jetting can be ideal carriers for targeted delivery in various applications.…”

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confidence: 99%

Engineering of nanoparticle size via electrohydrodynamic jetting

Rahmani

Ashraf

Hartmann

et al. 2016

Bioengineering & Transla Med

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Engineering the physical properties of particles, especially their size, is an important parameter in the fabrication of successful carrier systems for the delivery of therapeutics. Here, various routes were explored for the fabrication of particles in the nanosize regime. It was demonstrated that the use of a charged species and/or solvent with high dielectric constant can influence the size and distribution of particles, with the charged species having a greater effect on the size of the particles and the solvent a greater effect on the distribution of the particles. In addition to the fabrication of nanoparticles, their fractionation into specific size ranges using centrifugation was also investigated. The in vitro particle uptake and intracellular transport of these nanoparticles was studied as a function of size and incubation period. The highest level of intralysosomal localization was observed for the smallest nanoparticle group (average of 174 nm), followed by the groups with increasing sizes (averages of 378 and 575 nm), most likely due to the faster endosomal uptake of smaller particles. In addition, the internalization of nanoparticle clusters and number of nanoparticles per cell increased with longer incubation periods. This work establishes a technological approach to compartmentalized nanoparticles with defined sizes. This is especially important as relatively subtle differences in size can modulate cell uptake and determine intercellular fate. Future work will need to address the role of specific targeting ligands on cellular uptake and intracellular transport of compartmentalized nanoparticles.

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confidence: 99%

Engineering of nanoparticle size via electrohydrodynamic jetting

Rahmani

Ashraf

Hartmann

et al. 2016

Bioengineering & Transla Med

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“…(Bahadur, Thapa, & Xu, ; B. Cheng et al, ; Cong et al, ; Y. Gao & Dong, ; F. Wu et al, ; Z. Xu, Liu, Kang, & Wang, ). This “intelligent” nanomedicine possesses the properties of programmed site‐specific drug release behavior for improved cancer treatment (R. Cheng, Meng, Deng, Klok, & Zhong, ; Kakwere et al, ; Sokolovskaya, Rahmani, Misra, Brase, & Lahann, ; F. Xu et al, ). The named DOX/Au@Pt‐cRGD nanocarrier showed controlled drug release behavior, which dual trigged by pH and NIR laser (Q. Yang et al, ).…”

Section: Dual and Multi‐responsive Nanomedicinementioning

confidence: 99%

Physical‐, chemical‐, and biological‐responsive nanomedicine for cancer therapy

Liao

Jia

et al. 2019

WIREs Nanomed Nanobiotechnol

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Cancer therapy is unsatisfactory as it typically has serious side effects, because normal cells in healthy organs are destroyed along with the tumor. Thus, researchers have tried to develop effective therapies with minimal side effects. One such method is to use nanotechnology to carry the drugs or therapeutic agents to the tumor region by secure encapsulation without leakage. Once the nanomedicine enters the target tumor site, it can release therapeutic agents in an effective manner. Accordingly, various nanomedicines have been developed to enhance the efficiency of cancer therapy and minimize the systematic toxicity. Here, we provide an overview and discuss the different types of responsive nanomedicines including physically, chemically, biologically, dual, and multi‐responsive nanomedicines, for the in situ release of cargos in recent years. We propose critical considerations that must be considered for the design of excellent stimuli‐nanomedicine. Furthermore, the possible directions for the development of successful stimuli‐responsive (smart) nanomedicine are highlighted. With the development of responsive nanomedicines, precise and personalized nanomedicine will be realized with great promise in the future. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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“…More recently, the development of electrohydrodynamic (EHD) cojetting, which imparts multiple chemical functionalities within distinct compartmental domains of both particles and fibers, has shown great promise in creating more complex drug delivery platforms as well as patterned targeting domains . Additionally, multicomponent fibers have shown promise in creating next‐generation tissue engineering constructs and stimuli‐responsive micro‐ and nanoactuators .…”

Section: Introductionmentioning

confidence: 99%

“…[6] This technology has been implemented in a variety of applications ranging from chemical sensors, [7,8] filtration membranes, [9,10] and tissue engineering, [10][11][12][13] to drug delivery vehicles [5,14] and microencapsulation. [15] More recently, the development of electrohydrodynamic (EHD) cojetting, [16] which imparts multiple chemical functionalities within distinct compartmental domains of both particles and fibers, has shown great promise in creating more complex drug delivery platforms [17][18][19] as well as patterned targeting domains. [20,21] Additionally, Electrohydrodynamic cojetting can result in fibers (electrospinning) and particles (electrospraying) with complex, bicompartmental architectures.…”

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confidence: 99%

Needleless Electrohydrodynamic Cojetting of Bicompartmental Particles and Fibers from an Extended Fluid Interface

Jordahl

Ramcharan

Gregory

et al. 2016

Macromol. Rapid Commun.

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Back Cover: 3D ordered macroporous films can be fabricated using ordered arrays of the monodispersed droplets as templates of the macropores, which are self-assembled in the space between two parallel flat glass plates. In the case with two or more layers, the lattice structure of the macroporous films also changes due to the confinement effects. Further details can be found in the article by Y. Iwai, Y. Uchida,* H. Yabu, and N. Nishiyama on page 1600502. Front Cover: 2D and 3D light-triggered modulation of hydrogel stiffness is described. UV lithography and 3D two-photon direct laser writing technology afford to alter hydrogel crosslinking degree in two and three dimensions, exploiting a specific chemistry design. Spatially controlled changes in hydrogel mechanical properties induce a biological response: elongated cells and higher proliferation are evident on 2D stiff patterns compared to the less cross-linked soft regions. 3D ordered macroporous films with a pore diameter of more than 100 μm can be fabricated using ordered arrays of monodispersed droplets self-assembling in the space between two flat glass plates as templates. As the gap between the glass plates changes, the number of the layer and the lattice structure of the macro-porous films change due to the confinement effects. A novel needleless electrohydrodynamic cojetting technique allows for the preparation of particles and fibers with two distinct compartments. Application of a high electric field results in the spontaneous formation of several distinct Taylor cones along a fluid interface, resulting in the deposition of bicompartmental fibers and particles. Production rates of fibers are more than 30 times higher than needle-based cojetting methods. Nanoparticles made by polymerization-induced self-assembly can show reversible stimulus-triggered polymorphism ("shape-shifting") that differs from the phase behaviour known for unimeric smart polymers. This review explains the background of this promising behaviour and summarises the current state-of-the-art. A hydrogel material with tailorable 2D and 3D cross-linking degree by conventional UV lithography and 3D two-photon direct laser writing technology is presented. Mechanical properties (e.g., stiffness) can be modulated to induce different cell behaviors: elongated cells and higher proliferation are evident on 2D stiff patterns compared to the less cross-linked soft regions. Communications

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Dual-Stimuli-Responsive Microparticles

Cited by 45 publications

References 44 publications

Engineering of nanoparticle size via electrohydrodynamic jetting

Engineering of nanoparticle size via electrohydrodynamic jetting

Physical‐, chemical‐, and biological‐responsive nanomedicine for cancer therapy

Needleless Electrohydrodynamic Cojetting of Bicompartmental Particles and Fibers from an Extended Fluid Interface

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