Dual-sensitive and folate-conjugated mixed polymeric micelles for controlled and targeted drug delivery

Wu, Wen Chung; Huang, Chi Ming; Liao, Po Wen

doi:10.1016/j.reactfunctpolym.2014.05.003

Cited by 20 publications

(5 citation statements)

References 38 publications

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“…24,25 Beyond the stimulus of temperature, many groups have capitalized on slightly acidic microenvironments (pH 6. 8-7.2) (such as those observed in tumor extracellular environments) to modulate the release of drugs from pHresponsive carriers [11][12][13][14][15][16][26][27][28][29][30][31][32][33] and/or interaction between localized cells and carriers. In the case of tumor microenvironments, the slightly acidic tumor conditions are attributed to the elevated metabolism and proliferation of tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Surface sulfonamide modification of poly(N‐isopropylacrylamide)‐based block copolymer micelles to alter pH and temperature responsive properties for controlled intracellular uptake

Cyphert

Recum

Yamato

et al. 2018

J Biomedical Materials Res

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Two different surface sulfonamide-functionalized poly(N-isopropylacrylamide)-based polymeric micelles were designed as pH-/temperature-responsive vehicles. Both sulfadimethoxine- and sulfamethazine-surface functionalized micelles were characterized to determine physicochemical properties, hydrodynamic diameters, zeta potentials, temperature-dependent size changes, and lower critical solution temperatures (LCST) in both pH 7.4 and 6.8 solutions (simulating both physiological and mild low pH conditions), and tested in the incorporation of a proof-of-concept hydrophobic antiproliferative drug, paclitaxel. Cellular uptake studies were conducted using bovine carotid endothelial cells and fluorescently labeled micelles to evaluate if there was enhanced cellular uptake of the micelles in a low pH environment. Both variations of micelles showed enhanced intracellular uptake under mildly acidic (pH 6.8) conditions at temperatures slightly above their LCST and minimal uptake at physiological (pH 7.4) conditions. Due to the less negative zeta potential of the sulfamethazine-surface micelles compared to sulfadimethoxine-surface micelles, and the proximity of their LCST to physiological temperature (37°C), the sulfamethazine variation was deemed more amenable for clinically relevant temperature and pH-stimulated applications. Nevertheless, we believe both polymeric micelle variations have the capacity to be implemented as an intracellular drug or gene delivery system in response to mildly acidic conditions. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1552-1560, 2018.

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Section: Introductionmentioning

confidence: 99%

Surface sulfonamide modification of poly(N‐isopropylacrylamide)‐based block copolymer micelles to alter pH and temperature responsive properties for controlled intracellular uptake

Cyphert

Recum

Yamato

et al. 2018

J Biomedical Materials Res

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“…Nowadays, designing novel polymeric micelles with the capability of dual or even multiple responsiveness is of great interest. PMs systems with dual responsiveness with at least one physically trigger are dual thermal/light-responsive ( Tang et al, 2016 ; Yang et al, 2019 ), dual thermal/pH-responsive ( Zhang et al, 2007 ; He et al, 2010 ; Jia et al, 2010 ; Lee et al, 2010 ; Yang et al, 2010 ; Jain et al, 2011 ; Ding et al, 2013 ; Wu et al, 2014 ; Khine et al, 2015 ; Chen et al, 2017c ; Zhou Z. et al, 2018 ; Ghamkhari et al, 2018 ; Uz et al, 2019 ), dual light/magnet-responsive ( Zheng S. et al, 2018 ), dual thermal/redox-responsive ( Liu et al, 2015 ; Xu J. W. et al, 2018 ; Gao and Dong, 2018 ), dual light/pH-responsive ( Meng et al, 2013 ; Li Z. et al, 2016 ; Wang T. et al, 2016 ), dual ultrasound/reduction-responsive ( Tong et al, 2013 ), dual light/reduction ( Parida et al, 2017 ), and dual thermal/CO 2 -responsive ( Yuan et al, 2016 ). Triple-triggered PMs are thermal/reduction/pH-responsive ( Sun et al, 2018b ; Qu et al, 2018 ), thermal/ultrasound/reduction-responsive ( Lin et al, 2018 ), and light/temperature/pH- responsive ( Falireas and Vamvakaki, 2018 ).…”

Section: Polymeric Micellesmentioning

confidence: 99%

Physically stimulus-responsive nanoparticles for therapy and diagnosis

et al. 2022

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Nanoparticles offer numerous advantages in various fields of science, particularly in medicine. Over recent years, the use of nanoparticles in disease diagnosis and treatments has increased dramatically by the development of stimuli-responsive nano-systems, which can respond to internal or external stimuli. In the last 10 years, many preclinical studies were performed on physically triggered nano-systems to develop and optimize stable, precise, and selective therapeutic or diagnostic agents. In this regard, the systems must meet the requirements of efficacy, toxicity, pharmacokinetics, and safety before clinical investigation. Several undesired aspects need to be addressed to successfully translate these physical stimuli-responsive nano-systems, as biomaterials, into clinical practice. These have to be commonly taken into account when developing physically triggered systems; thus, also applicable for nano-systems based on nanomaterials. This review focuses on physically triggered nano-systems (PTNSs), with diagnostic or therapeutic and theranostic applications. Several types of physically triggered nano-systems based on polymeric micelles and hydrogels, mesoporous silica, and magnets are reviewed and discussed in various aspects.

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“…They demonstrated that FA-hyd micelles had significantly more circulation time and enriched drug into the tumors rather than normal tissues [19]. The similar results were reached in another investigation using two series of FA-targeted pH-sensitive amphiphilic block copolymers, poly(ε-caprolactone)-b-poly[triethylene glycol methacrylate-co-N-methacryloyl caproic acid] and poly(ε-caprolactone)-b-poly[triethylene glycol methacrylate-co-N-(2-(methacrylamido)ethyl] in vitro in FR-positive (HeLa) and FR-negative (HT-29) tumor cell lines [20]. There are other reports, which applied pH-dependent drug release approach for the control of tumor growth in FA-targeted micelles.…”

Section: Polymeric Micellesmentioning

confidence: 99%

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

et al. 2015

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The selective and efficient drug delivery to tumor cells can remarkably improve different cancer therapeutic approaches. There are several nanoparticles (NPs) which can act as a potent drug carrier for cancer therapy. However, the specific drug delivery to cancer cells is an important issue which should be considered before designing new NPs for in vivo application. It has been shown that cancer cells over-express folate receptor (FR) in order to improve their growth. As normal cells express a significantly lower levels of FR compared to tumor cells, it seems that folate molecules can be used as potent targeting moieties in different nanocarrier-based therapeutic approaches. Moreover, there is evidence which implies folate-conjugated NPs can selectively deliver anti-tumor drugs into cancer cells both in vitro and in vivo. In this review, we will discuss about the efficiency of different folate-conjugated NPs in cancer therapy.

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Dual-sensitive and folate-conjugated mixed polymeric micelles for controlled and targeted drug delivery

Cited by 20 publications

References 38 publications

Surface sulfonamide modification of poly(N‐isopropylacrylamide)‐based block copolymer micelles to alter pH and temperature responsive properties for controlled intracellular uptake

Surface sulfonamide modification of poly(N‐isopropylacrylamide)‐based block copolymer micelles to alter pH and temperature responsive properties for controlled intracellular uptake

Physically stimulus-responsive nanoparticles for therapy and diagnosis

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

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