Dual sensing of methionine and aspartic acid in aqueous medium by a quinoline-based fluorescent probe

Abstract

Quinoline based Schiff base 6-methyl-2-oxo-1,2-dihydro-quinoline-3carboxaldehyde-4(N)-phenylsemicarbazone (6MPS) sensor has been developed for selective sensing of methionine and aspartic acid in aqueous medium through selective detection of copper ion as “on-off-on” type....

Discriminative ‘Turn-on’ Detection of Al3+ and Ga3+ Ions as Well as Aspartic Acid by Two Fluorescent Chemosensors

“…Therefore, designing a chemosensor that can selectively detect an amino acid is always difficult [ 77 ]. Chemosensors L1 and L2 containing electron-rich groups and various binding sites make them ideal for the detection of amino acids [ 27 , 29 ]. Hence, the detection ability of L1 and L2 was checked towards all 20 amino acids: Gly, Ala, Glu, Pro, Cys, Ile, Tyr, Arg, Gln, Lys, Thr, Asp, Asn, His, Leu, Met, Phe, Ser, Trp, and Val.…”

“…Amongst all nonessential amino acids, Aspartic Acid (Asp) plays several critical roles in various biological and physiological processes [ 24 , 25 , 26 ]. Asp is specifically required for its role in the tricarboxylic acid (TCA) cycle [ 27 , 28 ]. Asp also serves as the main precursor for the synthesis of two amino acids, i.e., Glutamic acid and Glycine [ 24 , 29 ].…”

“…Asp acts as a major excitatory neurotransmitter in the mammalian central nervous system [ 24 , 30 ]. Studies have shown the use of K + Asp as a cure for heart and liver diseases and diabetes, but a higher amount of Asp can also cause Lou Gehrig’s disease, and it is also connected with the early onset of Alzheimer’s disease [ 25 , 27 , 30 ]. Therefore, the selective and sensitive detection of Asp is quite essential.…”

A fast survey on recent developments in designing colorimetric and fluorescent sensors for the selective detection of essential amino acids

“…Analytical Methods off-on" type of mechanism. 75 Ligand 63 initially exhibited uorescence but the addition of Cu 2+ resulted in the sudden quenching of the uorescence intensity. Upon the addition of aspartic acid/methionine to the complex solution, a notable increase in the uorescence intensity was observed.…”

“…Prabhakaran et al reported the copper( ii ) complex of a quinoline-based Schiff base sensor ( 63 ) for the selective detection of methionine in aqueous medium through an “on–off–on” type of mechanism. 75 Ligand 63 initially exhibited fluorescence but the addition of Cu 2+ resulted in the sudden quenching of the fluorescence intensity. Upon the addition of aspartic acid/methionine to the complex solution, a notable increase in the fluorescence intensity was observed.…”