Dual-screening of anti-inflammatory and antioxidant active ingredients of shenxiang suhe pill and its potential multi-target therapy for coronary heart disease

Liu, Jinghua; Wang, Siwei; Tan, Wangxiao; Lv, Bin; Dai, Yongna; Wang, Yu; Zhang, Zhaojian; Wang, Xiaoying

doi:10.1016/j.biopha.2020.110283

Cited by 11 publications

(2 citation statements)

References 12 publications

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“…The result showed that blumeatin (0.01 mmol/L and 0.1 mmol/L) and luteolin (0.01 mmol/L, 0.1 mmol/L and 1 mmol/L) have anti-inflammatory activity by inhibit NF-ĸB expression. Ingenuity pathway analysis (IPA) predicted that blumeatin has an anti-inflammatory effect related to Hif-1α [17]. Luteolin and luteolin-7-O-glycoside have been reported for anti-inflammatory effects due to TNF-α inhibition [18].…”

Section: Discussionmentioning

confidence: 99%

The potency of blumeatin and luteolin as caspase-1 inhibitor by molecular docking

Pratama¹,

Putra²,

Pujasari³

et al. 2022

Pharm.Rep.

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COVID-19 infection induces inflammation by increasing cytokines such as IL-1b, IL-6, IL-18, IFN-γ, and TNF-α. IL-1b is generated by the involvement of caspase-1. Therefore, caspase-1 inhibitor can be potential for inflammation therapy caused by COVID-19 infection. This study aims to determine the potential of blumeatin and luteolin as anti-inflammatory agents by inhibiting caspase-1 using a molecular docking approach. This study was carried out by caspase-1 (PDB ID: 1RWK) preparation, blumeatin and luteolin structure optimization, docking protocol validation, and docking of blumeatin and luteolin on caspase-1. Bluematin and luteolin had a binding affinity of -5,63 kcal/mol and -5,93 kcal/mol, lower than Q158 native ligand (-3.92 kcal/mol). Similar amino acid residues in hydrogen bonds interaction were observed between Q158 native ligand, blumeatin, and luteolin with caspase-1 (GLN 283 and ARG 179). Blumeatin and luteolin are potentially anti-inflammation agents through the inhibition of the caspase-1 in silico.

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Section: Discussionmentioning

confidence: 99%

The potency of blumeatin and luteolin as caspase-1 inhibitor by molecular docking

Pratama¹,

Putra²,

Pujasari³

et al. 2022

Pharm.Rep.

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show abstract

“…Moreover, the prevention and treatment of coronary heart disease may be related to related biological processes such as stress response, immune-inflammatory response, signal transduction, and atherosclerotic plaque instability by Choerospondias axillaris. COX-2 was reported to be a key enzyme that participated in platelet aggregation, and regulate the resistance of peripheral blood vessels and the distribution of renal blood flow (6)(7)(8). Therefore, it is of great importance that started with COX-2 to study the active pharmaceutical compounds and their mechanism of action from Choerospondias axillaris.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Ligand Fishing Using Immobilized Cyclooxygenase-2 for Identification and Screening of Anticoronary Heart Disease Ligands From Choerospondias axillaris

Miaomiao¹,

Wang²,

Yan³

et al. 2022

Front. Nutr.

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Inhibition of cyclooxygenase-2 (COX-2) activity is an effective way for treatment of coronary heart disease. And as an important source of COX-2 inhibitors, bioactive compounds of Choerospondias axillaris and pharmacological mechanisms remained lacking in prospective researches. Therefore, for the purpose of accelerating the discovery of natural products targeting designed inhibitors, the COX-2 microreactor composed of functionalized microspheres and magnetic ligand fishing was developed and applied in Choerospondias axillaris, and the physicochemical properties of the COX-2 functionalized microspheres were characterized using Fourier transform infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Furthermore, the bioactive compounds singled out from ethanol decoction without prepurification were dissociated and identified by ultraperformance liquid chromatography plus Q-Exactive Orbitrap tandem mass spectrometry (UPLC-Q-Exactive Orbitrap-MS/MS). Consequently, 21 bioactive compounds consisting of 6 organic acids, 8 flavonoids, and 7 others were separated and characterized from Choerospondias axillaris, which were reported to participate in the COX-2 inhibitory pathway to varying degrees. Therefore, this method could provide a prospective solution for the extraction and identification of active pharmaceutical ingredients and the rapid screening of some enzyme inhibitors in the complex mixtures.

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The extract of Gnaphalium affine D. Don protects against H2O2-induced apoptosis by targeting PI3K/AKT/GSK-3β signaling pathway in cardiomyocytes

Meng

Chen

et al. 2021

Journal of Ethnopharmacology

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Dual-screening of anti-inflammatory and antioxidant active ingredients of shenxiang suhe pill and its potential multi-target therapy for coronary heart disease

Cited by 11 publications

References 12 publications

The potency of blumeatin and luteolin as caspase-1 inhibitor by molecular docking

The potency of blumeatin and luteolin as caspase-1 inhibitor by molecular docking

Magnetic Ligand Fishing Using Immobilized Cyclooxygenase-2 for Identification and Screening of Anticoronary Heart Disease Ligands From Choerospondias axillaris

The extract of Gnaphalium affine D. Don protects against H2O2-induced apoptosis by targeting PI3K/AKT/GSK-3β signaling pathway in cardiomyocytes

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