2014
DOI: 10.1016/b978-0-12-800177-6.00007-4
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Dual Roles of Orphan Nuclear Receptor TR3/Nur77/NGFI-B in Mediating Cell Survival and Apoptosis

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Cited by 31 publications
(16 citation statements)
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“…Subsequently, the overexpression of Nur77 in breast cancer cell xenografts was reported to alter the inflammatory response and increase the risk of metastatic disease in mice ( 30 ). Another study suggested that the cytoplasmic expression of Nur77 can induce apoptosis in breast cancer cells ( 31 ). Notably, one report demonstrated that Nur77 is involved in the migration of transforming growth factor-β-induced breast cancer cells ( 32 ); furthermore, this process is dependent on p38α ( 33 ).…”
Section: Structure Expression and Localization Of Nur77mentioning
confidence: 99%
“…Subsequently, the overexpression of Nur77 in breast cancer cell xenografts was reported to alter the inflammatory response and increase the risk of metastatic disease in mice ( 30 ). Another study suggested that the cytoplasmic expression of Nur77 can induce apoptosis in breast cancer cells ( 31 ). Notably, one report demonstrated that Nur77 is involved in the migration of transforming growth factor-β-induced breast cancer cells ( 32 ); furthermore, this process is dependent on p38α ( 33 ).…”
Section: Structure Expression and Localization Of Nur77mentioning
confidence: 99%
“…Nur77 plays a critical role in inflammation and in cellular processes, such as proliferation, differentiation, survival and death (9). Previous researchers investigating Nur77 have focused mostly on neurological disorders, cardiovascular diseases and cancer (10). Nur77 expression has been described in lung tissue and lung epithelial cells.…”
Section: Introductionmentioning
confidence: 99%
“…NR4A1 overexpression in breast cancer cell line xenografts results in altered inflammatory response and increased risk for metastatic disease [29]. However, cytoplasmic NR4A1 can contribute to apoptosis of breast cancer cells [22]. We were able to show that NR4A1 expression at baseline is relatively high within normal ovarian tissue as compared to a number of other human tissue types.…”
Section: Discussionmentioning
confidence: 95%