Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy

Huang, Run; Chen, Huan; Liang, Jiayu; Li, Yang; Yang, Jiali; Luo, Chuang; Tang, Youshan; Ding, Yu; Liu, Xing; Yuan, Qing; Yu, Hong; Ye, Yingchun; Xu, Wangyang; Xie, Xiang

doi:10.7150/jca.54699

Cited by 70 publications

(65 citation statements)

References 185 publications

(255 reference statements)

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“…Consistent with the studies on the relationship of iron and GC, ferroptosis has also been found to be closely related to the proliferation, invasion, and metastasis in GC ( Chen et al, 2021a ; Huang et al, 2021 ). However, the predictive role of ferroptosis in GC remains elusive ( Shao et al, 2021 ).…”

Section: Ferroptosis In Gastric Cancersupporting

confidence: 85%

Ferroptosis and its Role in Gastric Cancer

Xia

et al. 2022

Front. Cell Dev. Biol.

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Gastric cancer (GC) is the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. Currently, surgery is the treatment of choice for GC. However, the associated expenses and post-surgical pain impose a huge burden on these patients. Furthermore, disease recurrence is also very common in GC patients, thus necessitating the discovery and development of other potential treatment options. A growing body of knowledge about ferroptosis in different cancer types provides a new perspective in cancer therapeutics. Ferroptosis is an iron-dependent form of cell death. It is characterized by intracellular lipid peroxide accumulation and redox imbalance. In this review, we summarized the current findings of ferroptosis regulation in GC. We also tackled on the action of different potential drugs and genes in inducing ferroptosis for treating GC and solving drug resistance. Furthermore, we also explored the relationship between ferroptosis and the tumor microenvironment in GC. Finally, we discussed areas for future studies on the role of ferroptosis in GC to accelerate the clinical utility of ferroptosis induction as a treatment strategy for GC.

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Section: Ferroptosis In Gastric Cancersupporting

confidence: 85%

Ferroptosis and its Role in Gastric Cancer

Xia

et al. 2022

Front. Cell Dev. Biol.

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“…Cancer cells contain high basal ROS levels, which cause sensitizes cells to excessive oxidative stress. Therefore, excessive ROS are also deadly to osteosarcoma cells [62] . Research has indicated that multiple chemotherapeutic agents induce apoptosis and autophagy in tumor cells through ROS generation [30] .…”

Section: Discussionmentioning

confidence: 99%

Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and β-catenin signaling pathways

Pang

Peng

et al. 2022

Journal of Bone Oncology

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“…7 ). ROS play a bidirectional role either in the initiation and development or in the suppression and treatment of cancer [ 62 – 64 ]. Several studies supported the effect of ROS production on the initiation, progression, and metastasis of several types of tumors.…”

Section: Discussionmentioning

confidence: 99%

Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosensitizers for eliminating pancreatic cancer stem cells

Salah

Akasaka

Shimizu

et al. 2022

J Exp Clin Cancer Res

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Background Despite recent advances in radiotherapy, radioresistance in patients with pancreatic cancer remains a crucial dilemma for clinical treatment. Cancer stem cells (CSCs) represent a major factor in radioresistance. Developing a potent radiosensitizer may be a novel candidate for the eradication of pancreatic CSCs. Methods CSCs were isolated from MIA PaCa-2 and PANC1 human pancreatic cancer cell lines. Titanium peroxide nanoparticles (TiOxNPs) were synthesized from titanium dioxide nanoparticles (TiO2NPs) and utilized as radiosensitizers when added one hour prior to radiation exposure. The antitumor activity of this novel therapeutic strategy was evaluated against well-established pancreatic CSCs model both in vitro and in vivo. Results It is shown that TiOxNPs combined with ionizing radiation exhibit anti-cancer effects on radioresistant CSCs both in vitro and in vivo. TiOxNPs exhibited a synergistic effect with radiation on pancreatic CSC-enriched spheres by downregulating self-renewal regulatory factors and CSC surface markers. Moreover, combined treatment suppressed epithelial-mesenchymal transition, migration, and invasion properties in primary and aggressive pancreatic cancer cells by reducing the expression of proteins relevant to these processes. Notably, radiosensitizing TiOxNPs suppressed the growth of pancreatic xenografts following primary or dissociating sphere MIA PaCa-2 cell implantation. It is inferred that synergy is formed by generating intolerable levels of reactive oxygen species (ROS) and inactivating the AKT signaling pathway. Conclusions Our data suggested the use of TiOxNPs in combination with radiation may be considered an attractive therapeutic strategy to eliminate pancreatic CSCs.

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Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy

Cited by 70 publications

References 185 publications

Ferroptosis and its Role in Gastric Cancer

Ferroptosis and its Role in Gastric Cancer

Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and β-catenin signaling pathways

Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosensitizers for eliminating pancreatic cancer stem cells

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