Dual role of inflammatory mediators in cancer

Shrihari, T G

doi:10.3332/ecancer.2017.721

Cited by 133 publications

(119 citation statements)

References 31 publications

(60 reference statements)

Supporting

Mentioning

116

Contrasting

Order By: Relevance

“…Also involved in autoimmune diseases by immune suppression, conversion of Th1 type lymphocyte to Th2 type, activation of proteolytic enzymes like MMPs (matrix metalloproteases) results in cellular changes ,tissue damage, and chronic inflammatory conditions by activating cytokines such as IL-1, TNF-α, IL-6 [6][7][8][9]. Stress buster activity by reducing cortisol, neuropeptides through HPA axis (hypothalamo-pituitary adrenal axis) and inhibiting activation of sympathetic nervous system and activation of parasympathetic nervous system of autonomic nervous system, which is involved in anti-inflammatory activity and peripheral immunity [10][11][12][13].…”

Section: Commentarymentioning

confidence: 99%

Quantum Healing Approach to New Generation of Holistic Healing

Tg¹

2017

Transl Med

View full text Add to dashboard Cite

CommentaryHuman body has its own mechanism of healing known as whole body healing. Each healthy cell of human body emit photon, disease is an altered emission of photons. Inside and outside of our body consists of energy. Photons from our cells jump on to others and counter photons may be vibrating at other place is known as quantum entanglement and quantum tunnelling. The concept of aduality states that matter can be converted in to energy and energy can be converted in to matter proposed by Nobel laureate Hans-Peter Dürr. Most of all diseases start in mind ends in mind. Mind is nothing but a part of human consciousness, is a canvas, on which our thoughts are projected. It is a holographic presentation of human body. Mind has a blue print of human body. Body tries to rebuild each time, when it oscillate between energy and particle 1044 times in a second. Human body is a holographic projection of human consciousness. With our positive thoughts or consciousness known as quantum thinking, which creates energy, with a genuine intention to heal, known as quantum healing akin to self healing or auto healing.Pranic healing, meditation, chi therapy with our positive thoughts, genuine intention to heal known as quantum thinking and healing takes place at spiritual level by producing endorphins [1].Endorphins are neuropeptides, endogenous morphine produced by pituitary gland and hypothalamus, receptors are present in brain and on immune cells. Endogenous opioids includes β-endorphins, enkephalins, and dynorphins, operate via µ-opioid receptor. Beta endorphin is the abundant endorphins secreted and synthesized by anterior pituitary gland, it is a precursor of protein proopiomelanocortin (POMC) [2]. It has got immune-stimulatory, anti-inflammatory, stress buster, euphoric, and analgesic activity. Immune-stimulatory due to activation of NK cells and macrophages producing IFN-ϒ, opsonin, granzyme-B, has an antiviral activity and anti-inflammatory activity.Anti-inflammatory activity is due to activation of IFN-ϒ and IL -18 and suppressing TNF-α, IL-1, IL-6 pro-inflammatory cytokines, suppress free radical release such as ROS, RNS and also suppressing key transcriptional factors NF-KB, STAT-3, which is involved in tumor progression by cell proliferation, cell survival, angiogenesis, immune suppression, genomic instability, invasion, metastasis [3][4][5]. Also involved in autoimmune diseases by immune suppression, conversion of Th1 type lymphocyte to Th2 type, activation of proteolytic enzymes like MMPs (matrix metalloproteases) results in cellular changes ,tissue damage, and chronic inflammatory conditions by activating cytokines such as IL-1, TNF-α, . Stress buster activity by reducing cortisol, neuropeptides through HPA axis (hypothalamo-pituitary adrenal axis) and inhibiting activation of sympathetic nervous system and activation of parasympathetic nervous system of autonomic nervous system, which is involved in anti-inflammatory activity and peripheral immunity [10][11][12][13]. Euphoric activity by inhibiting an inhibitor...

show abstract

Section: Commentarymentioning

confidence: 99%

Quantum Healing Approach to New Generation of Holistic Healing

Tg¹

2017

Transl Med

View full text Add to dashboard Cite

show abstract

“…Catacholamines may promote cancer cell attachments, norepinephrine and epinephrine promote migration and invasive potential of ovarian cancer cells by increasing MmP-2,9 important for tumor invasion. Stress hormones including norepinephrine promote tumor progression, angiogenesis by production of IL-6, VEGF activates STAT3 transcriptional factor involved in cell proliferation and cell survival [3,10,11]. Chronic stress affects recruitment of neutrophils, NK, macrophages, APCs, T and B lymphocytes.…”

Section: Role Of Stress In Cancermentioning

confidence: 99%

“…Leukemia's are due to chemical ingestions, HPV induced oropharyngeal carcinoma and cervical cancer. Endorphins are endogenous morphins responsible for relaxed psychological state creation known as "runner's high" [1][2][3][4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Endorphins on Cancer: A Novel Therapeutic Approach

Tg¹

2017

J Carcinog Mutagen

View full text Add to dashboard Cite

Endorphins are natural neuropeptides secreted by anterior pituitary gland through hypothalamus in response to stress full conditions such as physical exercise, yoga and meditation. Stress is also a one of the predisposing factor for cancer by activating inflammatory mediators such as IL-1 and TNF-α, involved in tumor progression. It has stress buster activity by reducing cortisol, analgesic activity by inhibiting substance P, euphoric activity by releasing dopamine and immune-stimulatory activity by activating NK cells, macrophages. It can be used for natural antitumor activity by activating NK cells, macrophage innate immune cells, and has anti-inflammatory activity by inducing IL-12, IL-8 cytokines. It has got it's receptors on the immune cells, binding of endogenous opioids such as beta endorphin to the receptors on the immune cells, activates immune cells. This article briefs about the role of Beta endorphin on cancers and its anticancer activities.

show abstract

“…Chronic inflammation results from persistent inflammatory stimuli (infectious, physical or chemical agents) triggering the release of inflammatory mediators 4 and the activation of endothelial cells and the immune system, leading to angiogenesis 5 .…”

Section: ■ Introductionmentioning

confidence: 99%

Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model

Melo

Alves²,

Silva³

et al. 2018

Acta Cir. Bras.

View full text Add to dashboard Cite

Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model 1 Abstract Purpose: To evaluate the effects of red propolis on cheek pouch angiogenesis in a hamster new model sponge implant. Methods: Forty eight animals divided into eight groups. (Groups I-IV), the animals were treated for 15 days before and 10 days after sponge implantation. (Groups V-VIII), the animals were treated for 10 days after sponge implantation (GI and GV: red propolis 100 mg/kg, GII and GVI: celecoxib 20 mg/kg, GIII and GVII: 1% gum arabic 5 mL/kg, GIV and GVIII: distilled water 5 mL/kg). On the 11th day of implantation, the animals were anesthetized for stereoscopic microscopic imaging and morphometric quantification of angiogenesis (SQAN), followed by histopathological evaluation (H&E). Results: In the SQAN analysis, no significant difference was found between the groups. However, on histology, propolis was found reduce the population of mastocytes in the qualitative analyses (p = 0,013) in the quantitative analyses to reduce the number of blood vessels (p = 0,007), and increase the macrophage count (p = 0,001). Conclusion: Red propolis inhibited inflammatory angiogenesis when administered before andcontinuously after sponge implant, and was shown to have immunomodulating effects on inflammatory cells (mastocytes and macrophages) in a new sponge implant hamster model.

show abstract

Dual role of inflammatory mediators in cancer

Cited by 133 publications

References 31 publications

Quantum Healing Approach to New Generation of Holistic Healing

Quantum Healing Approach to New Generation of Holistic Healing

Endorphins on Cancer: A Novel Therapeutic Approach

Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model

Contact Info

Product

Resources

About