Dual role of complement in adipose tissue

Pattrick, Michael; Luckett, Jeni; Yue, Liang; Stover, Cordula M.

doi:10.1016/j.molimm.2008.09.013

Cited by 51 publications

(47 citation statements)

References 46 publications

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“…Complement appears to make fundamental contributions to the maintenance of normal biological function of adipose as well as contribute to local and systemic immune responses (19). Here we find for the first time that complement was activated in adipose tissue in response to ethanol feeding, evidenced by the accumulation of two C3 cleavage products, C3b and C3d, in adipose tissue from mice after ethanol feeding.…”

Section: Making Use Of Cyp2e1mentioning

confidence: 54%

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Identification of a Cytochrome P4502E1/Bid/C1q-dependent Axis Mediating Inflammation in Adipose Tissue after Chronic Ethanol Feeding to Mice

Sebastian

Roychowdhury

Tang

et al. 2011

Journal of Biological Chemistry

114

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Background: Chronic alcohol consumption leads to inflammation in adipose tissue, disrupting normal metabolic activity of adipocytes. Results: Expression of an alcohol metabolizing enzyme, cytochrome P4502E1, initiates inflammation in adipose. Bid-dependent apoptosis and activation of complement then exacerbate this initial response. Conclusion: Adipose inflammation during alcohol feeding develops in response to cytochrome P450 expression. Significance: Preventing adipose inflammation may prevent the pathphysiological effects of ethanol.

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Section: Making Use Of Cyp2e1mentioning

confidence: 54%

“…Adipose tissue produces C3, factor B, and factor D, essential components for the alternative pathway of activation, as well as properdin, several complement receptors, and regulatory proteins (19). The C3a receptor was recently identified as a key determinant of insulin resistance and adipose tissue inflammation in diet-induced obesity in mice (20).…”

mentioning

confidence: 99%

Identification of a Cytochrome P4502E1/Bid/C1q-dependent Axis Mediating Inflammation in Adipose Tissue after Chronic Ethanol Feeding to Mice

Sebastian

Roychowdhury

Tang

et al. 2011

Journal of Biological Chemistry

114

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“…Inflammatory mediators are derived from immune cells, and inflammatory cytokines have been the subject of several recent studies (Berg & Scherer 2005;Cancello & Clement 2006;Brandtzaeg 2010). Inflammatory factors have been associated with the complement system (White et al 1992;Pattrick et al 2009), and there is evidence of the impact of complement proteins on immune mediators, both during pregnancy and breastfeeding (Sodowski et al 2008;França et al 2010;Morceli et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Inflammatory cytokines as mediators of inflammation have recently been in the research spotlight (Berg & Scherer 2005;Cancello & Clement 2006). Inflammatory factors have been associated with complement (White et al 1992;Pattrick et al 2009). However, there is a lack of information on the impact of complement-mediated inflammation, particularly during pregnancy (Sodowski et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Maternal hypertension induces alterations in immunological factors of colostrum and human milk

Massmann

França

Souza

et al. 2013

Frontiers in Life Science

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The aim of this study was to evaluate the changes in minerals, antibodies, complement and cytokine levels in the human milk of hypertensive women based on the time of collection (diurnal/nocturnal) and the type of milk. The material was collected from 23 mothers at three stages of maturity: 3 days (colostrum), 10 days (transitional milk) and 30 days (mature milk) postpartum -and at two times -diurnal (12:00 h) and nocturnal (24:00 h) -resulting in a total of 138 samples. The minerals, antibody, complement, IFN-γ and TGF-β cytokine levels were determined. Increases in sodium and potassium were observed independent of phase, while phosphorus was observed only during nocturnal period. IgA was higher in the transitional milk of hypertensive mothers in the nocturnal period. IgG was higher in the nocturnal period of hypertensive mothers regardless of milk maturation. The C3 protein increased during the diurnal period in the transitional and mature milk of hypertensive women. Milk concentrations of the cytokines IFN-γ and TGF-β were higher during the nocturnal period of hypertensive mothers. These data suggest that the milk of hypertensive mothers exhibits alterations proteins and inflammatory mediators, and these alterations are dependent on time and milk maturation.

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“…There are also historic links between the activation of the alternative complement pathway by C3 nephritic factor and lipodystrophy. [32][33][34] Bb may be a potential biomarker of an obesity-related chronic inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

The Interrelationship of Complement-Activation Fragments and Angiogenesis-related Factors in Early Pregnancy and Their Association With Preeclampsia

Lynch

Murphy

Gibbs

et al. 2011

Obstetric Anesthesia Digest

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Objective-To determine the interrelationships during early pregnancy of complement-activation fragments Bb, C3a and sC5b-9, and angiogenesis-related factors placental growth factor (PiGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), and their associations with pre-eclampsia. Design-Prospective cohort study. Setting-Denver complement study (June 2005-June 2008).Population-A total of 668 pregnant women with singleton gestations, recruited between 10 and 15 weeks of gestation.Methods-Using univariable and multivariable logistic regression analysis, concentrations of complement-activation fragments and angiogenesis-related factors were compared between 10 and Correspondence: Dr A Lynch, Department of Obstetrics and Gynecology, University of Colorado Denver School of Medicine, Mail Stop B198, 12631 East 17th Avenue, Aurora, CO 80045, USA. anne.lynch@ucdenver.edu. Disclosure of interestsThe authors have nothing to disclose. Contribution to authorshipAML designed and oversaw the study, conducted the data analysis, obtained the funding and wrote the manuscript; JRM provided statistical consultation; PCG provided consultation on the interpretation of complement results; RJL contributed his expertise in the area of angiogenesis-related factors; RSG contributed his expertise in maternal-fetal medicine. VMH and JES contributed their expertise in the area of complement research, and VMH served as mentor to AML on her NICHD K23 grant. Details of ethics approvalThe Colorado Multiple Institutional Review Board approved the study (COMIRB protocol number 07-0960). Interrelationships between these variables were tested using the non-parametric Spearman rank correlation coefficient. HHS Public AccessMain outcome measure-Pre-eclampsia. The association of complement-activation fragments and angiogenesis-related factors with obesity was also examined.Results-The mean (±SD) levels of complement Bb in early pregnancy among women who did and did not develop pre-eclampsia were 0.84 (±0.26) µg/ml and 0.69 (±0.2) µg/ml, respectively (P = 0.001). Concentrations of PiGF were significantly (P = 0.01) lower (31 ± 12 pg/ml) in early pregnancy in the pre-eclamptic group of women, as compared with the normotensive group (39 ± 32 pg/ml). The adjusted odds ratio (AOR) of Bb and PiGF were 2.1 (CI = 1.4-3.1, P < 0.0003) and 0.2 (CI = 0.07-0.7, P = 0.01), respectively. There was no significant difference in the levels of C3a, sC5b-9, sFlt-1 and sEng in early pregnancy among women who developed pre-eclampsia, compared with women who remained normotensive during pregnancy. Higher levels of Bb (P = 0.0001) and C3a (P = 0.03), and lower levels of sFlt-1 (P = 0.0002) and sEng (P = 0.0001) were found among women with obesity, compared with non-obese controls. No meaningful relationships were found between the complement-activation fragments and the angiogenesisrelated factors.Conclusions-In this cohort during early pregnancy, increased concentrations of complementactivation factor Bb and lower concentrations of PiGF were ...

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Dual role of complement in adipose tissue

Cited by 51 publications

References 46 publications

Identification of a Cytochrome P4502E1/Bid/C1q-dependent Axis Mediating Inflammation in Adipose Tissue after Chronic Ethanol Feeding to Mice

Identification of a Cytochrome P4502E1/Bid/C1q-dependent Axis Mediating Inflammation in Adipose Tissue after Chronic Ethanol Feeding to Mice

Maternal hypertension induces alterations in immunological factors of colostrum and human milk

The Interrelationship of Complement-Activation Fragments and Angiogenesis-related Factors in Early Pregnancy and Their Association With Preeclampsia

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