Dual‐Responsive Nanocomposites for Synergistic Antibacterial Therapies Facilitating Bacteria‐Infected Wound Healing

Abstract

The rising dangers of bacterial infections have created an urgent need for the development of a new generation of antibacterial technologies and therapeutics. Antibacterial photodynamic therapy (PDT), considered as a noninvasive treatment with no drug resistance, has become a new promising photochemistry‐involved treatment strategy. Titanium oxide (TiO2) is proved to be a very efficient PDT agent among the photosensitive materials, while the property of a large bandgap of TiO2 makes it only be excited by ultraviolet light, which is harmful to organisms. In this work, a novel ligand‐to‐metal charge transfer (LMCT) mediated TiO2 PDT strategy is proposed via the harmless near‐infrared light irradiation. By choosing a mussel‐inspired material, polydopamine (PDA) is involved in forming mesoporous TiO2@PDA nanoparticles (mTiO2@PDA NPs). The catechol groups of PDA can attach the TiO2 tightly even in colloidal environments, and can also form the LMCT bridge, exciting TiO2 to exert PDT function via 808 nm irradiation. Combining the sonodynamic therapy (SDT) of TiO2 and the photothermal therapy properties of PDA, this simple structure mTiO2@PDA enables synergistic antibacterial applications with multiple functions under the dual excitation of NIR and ultrasound. This reliable all‐in‐one NPs can achieve great antibacterial effect and a rapid repair of infected wounds.

Recent advances on nanomaterials for antibacterial treatment of oral diseases

“…Its superior mechanical properties and low cost make it ideal material for implant and antibacterial fillers. Titanium dioxide has a wide antibacterial spectrum and has antibacterial effect on S. mutans , S. aureus , Fusobacterium nucleatum ( F. nucleatum ), P. gingivalis , etc [ 61 ]. Totu et al.…”

In the View of Electrons Transfer and Energy Conversion: The Antimicrobial Activity and Cytotoxicity of Metal‐Based Nanomaterials and Their Applications

“…Similarly, Cheng et al synthesized the TiO 2 and polydopamine cross-linked mesoporous nanoparticles (mTiO 2 @PDA NPs), which shows a combined synergistic effect of sonodynamic therapy and photothermal therapy under the dual excitation of NIR and ultrasound. [288] In addition, Cheng et al reported on the light-responsive photothermal and ROS synergistic therapy of ZnTCPP(porphyrin-metal complex)/Ti 3 C 2 T x organic-inorganic composites. [289] The Schottky junction formed between Ti 3 C 2 T x and ZnTCPP promotes visible light utilization, accelerates charge separation, and enhances the mobility of photogenerated charges.…”

“…synthesized the TiO 2 and polydopamine cross‐linked mesoporous nanoparticles (mTiO 2 @PDA NPs), which shows a combined synergistic effect of sonodynamic therapy and photothermal therapy under the dual excitation of NIR and ultrasound. [ 288 ] In addition, Cheng et al. reported on the light‐responsive photothermal and ROS synergistic therapy of ZnTCPP(porphyrin–metal complex)/Ti 3 C 2 T x organic–inorganic composites.…”

Rapid Light Response of a Novel Bi‐Based Metal–Organic Framework for Bacterial Wound Infections Treatment

“…[4][5][6] However, while antibiotics can achieve rapid sterilization, the indiscriminate use and abuse of antibiotics can cause strong side effects in the human body and accelerate the emergence of drug-resistant bacteria, as well as super drug-resistant bacteria. [7,8] To solve this tricky dilemma, various nanomaterials, such as precious metals, [9] semiconductors, [10] and carbon-based materials, [11] have proliferated in the field of antimicrobial research. As they can kill bacteria by generating reactive oxygen species (ROS, such as 1 O 2 , •OH, and •O 2 − ) through local plasma effects, the release of ions, or photogenerated electrons and holes react with surrounding oxygen or water, these antibacterial nanomaterials came to be known as photodynamic therapy (PDT) in killing bacteria by damaging their DNA, enzymes, and proteins.…”

“…To solve this tricky dilemma, various nanomaterials, such as precious metals, [ 9 ] semiconductors, [ 10 ] and carbon‐based materials, [ 11 ] have proliferated in the field of antimicrobial research. As they can kill bacteria by generating reactive oxygen species (ROS, such as 1 O 2 , · OH, and · O 2 − ) through local plasma effects, the release of ions, or photogenerated electrons and holes react with surrounding oxygen or water, these antibacterial nanomaterials came to be known as photodynamic therapy (PDT) in killing bacteria by damaging their DNA, enzymes, and proteins.…”