Rapid Light Response of a Novel Bi‐Based Metal–Organic Framework for Bacterial Wound Infections Treatment

Abstract

Bismuth metal–organic frameworks (MOFs) as catalysts are scarce. Herein, the first MOF comprising meso‐ tetra(4‐carboxyphenyl) porphine (TCPP) as an organic ligand and Bi ion as a metal node, denoted as Bi‐TCPP, is synthesized by a convenient one‐step hydrothermal method. Compared to other 2D (Cu‐TCPP) or 3D (PCN‐222) MOFs with TCPP as a ligand, Bi‐TCPP has ultrafast singlet oxygen generation ability and a high photothermal conversion efficiency of 49.5% under the irradiation of 660 nm light. This is due to Bi‐TCPP's strong ligand‐to‐metal charge transfer (LMCT) events that form singlet oxygen (1O2). Further, when the electrons and holes above the bandgap relax to the band edge, the excess energy is converted into heat. In vitro and in vivo experiments show excellent antibacterial and repair effects. Hence, the synthesis of Bi‐TCPP provides new ideas for the study of rare bismuth‐based MOFs, and its excellent biocompatibility provides a possibility for further application.

Application of metal-organic frameworks in infectious wound healing

“…Wu et al coordinated tetrakis (4-carboxyphenyl) porphyrin (TCPP), an organic ligand with Bi ions, to form Bi-TCPP. Bi-TCPP possesses ultrafast unilinear oxygen-generating capacity and high photothermal conversion efficiency under 660 nm light irradiation and can effectively heal infected wounds [ 122 ]. Cu 2+ was doped into the porphyrin ring of an MOF (PCN 224) composed of zirconium (Zr).…”