Dual responsive magnetic composite nanogels for thermo-chemotherapy

Indulekha, S.; Arunkumar, P.; Bahadur, D.; Srivastava, Rohit

doi:10.1016/j.colsurfb.2017.04.035

Cited by 51 publications

(50 citation statements)

References 35 publications

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“…More specifically, several RC-DDS based on thermoresponsive polymers and superparamagnetic nanoparticles (MNPs) have been used for remotely trigger drug release by applying AMF: magnetic-thermoresponsive micro/nanogels [9][10][11] , microbeads 12 , nanobeads 13 , nanocubes 14 , polymersomes 15 , but most of the time a macroscopic heating of the medium is needed for drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin Intracellular Remote Release from Biocompatible Oligo(ethylene glycol) Methyl Ether Methacrylate-Based Magnetic Nanogels Triggered by Magnetic Hyperthermia

Cazares-Cortes

Espinosa

Guigner

et al. 2017

ACS Appl. Mater. Interfaces

111

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Hybrid nanogels, composed of thermoresponsive polymers and superparamagnetic nanoparticles, are attractive nanocarriers for biomedical applications, being able-as a polymer matrix-to uptake and release high quantities of chemotherapeutic agents and-as magnetic nanoparticles-to be heated when exposed to an alternative magnetic field (AMF), better known as magnetic hyperthermia. Herein, biocompatible, pH-responsive, magnetoresponsive, and thermoresponsive nanogels, based on oligo(ethylene glycol) methyl ether methacrylate monomers and a methacrylic acid comonomer were prepared by conventional precipitation radical copolymerization in water, post-assembled by complexation with iron oxide magnetic nanoparticles (MNPs) of maghemite (γ-FeO), and loaded with an anticancer drug (doxorubicin, DOX), for remotely controlled drug release by a "hot spot", as an athermal magnetic hyperthermia strategy against cancer. These nanogels, denoted MagNanoGels, with a hydrodynamic diameter from 328 to 460 nm, as a function of the MNP content, have a swelling-deswelling behavior at their volume phase temperature transition around 47 °C in a physiological medium (pH 7.5), which is above the human body temperature (37 °C). Applying an alternative magnetic field increases the release of DOX by 2-fold, while no macroscopic heating was recorded. This enhanced drug release is due to a shrinking of the polymer network by local heating, as illustrated by the MagNanoGel size decrease under an AMF. In cancer cells, not only do the DOX-MagNanoGels internalize DOX more efficiently than free DOX, but also DOX intracellular release can be remotely triggered under an AMF, in athermal conditions, thus enhancing DOX cytotoxicity.

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Section: Introductionmentioning

confidence: 99%

Doxorubicin Intracellular Remote Release from Biocompatible Oligo(ethylene glycol) Methyl Ether Methacrylate-Based Magnetic Nanogels Triggered by Magnetic Hyperthermia

Cazares-Cortes

Espinosa

Guigner

et al. 2017

ACS Appl. Mater. Interfaces

111

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“…PVCL has also been utilized for the preparation of stimuli-responsive nanoparticles and nanofibers [ 37 ]. For instance, González et al prepared thermoresponsive nanofibers via the electrospinning technique and investigated their use in drug delivery systems.…”

Section: Thermosensitive Polymersmentioning

confidence: 99%

“…Stimuli-responsive nanostructures have the potential to be used for targeted delivery and controlled drug release. The pH [ 35 ], temperature [ 36 ], magnetic field [ 37 ] and redox reaction [ 38 , 39 ] are the most commonly used environmental factors in stimuli-responsive systems. Stimuli-responsive nanocarriers have the potential to induce enhanced permeability [ 40 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications

Ghaeini-Hesaroeiye

Bagtash

Boddohi

et al. 2020

Gels

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Nanogels, or nanostructured hydrogels, are one of the most interesting materials in biomedical engineering. Nanogels are widely used in medical applications, such as in cancer therapy, targeted delivery of proteins, genes and DNAs, and scaffolds in tissue regeneration. One salient feature of nanogels is their tunable responsiveness to external stimuli. In this review, thermosensitive nanogels are discussed, with a focus on moieties in their chemical structure which are responsible for thermosensitivity. These thermosensitive moieties can be classified into four groups, namely, polymers bearing amide groups, ether groups, vinyl ether groups and hydrophilic polymers bearing hydrophobic groups. These novel thermoresponsive nanogels provide effective drug delivery systems and tissue regeneration constructs for treating patients in many clinical applications, such as targeted, sustained and controlled release.

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“…Dox chemotherapy in combination with induced hyperthermia by MNPs demonstrated a synergistic therapeutic effect against breast cancer cells. [199] Small molecules in combination with hyperthermia have also been explored in the quest of improving cancer therapy. For example, TRAIL and MNPs complexed with the thermosensitive polymer poly(organophosphazene), exhibited significant tumor reduction in human glioblastoma and human prostate cancer cell lines.…”

Section: Chemo-thermal Combination Therapiesmentioning

confidence: 99%

“…Another recent study reported the synthesis of nanocomposites formed by MNPs and dual‐responsive chitosan‐ g ‐poly(N‐vinylcaprolactam) (PNVCL) polymer for synergistic chemo‐thermal therapy. Dox chemotherapy in combination with induced hyperthermia by MNPs demonstrated a synergistic therapeutic effect against breast cancer cells . Small molecules in combination with hyperthermia have also been explored in the quest of improving cancer therapy.…”

Section: Combination Of Chemotherapeutic Agents and Energy‐based Thermentioning

confidence: 99%

Nanoparticles‐Mediated Combination Therapies for Cancer Treatment

Shrestha

Tang

Romero

2019

Advanced Therapeutics

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Cancer is a dynamic disease characterized by its heterogeneous nature. This heterogeneity results in critical problems that interfere with the eradication of cancer tumors such as multidrug resistance, drug efflux capacity, narrow therapeutic window, and undesired side effects. Nanomedicine has introduced new platforms for drug delivery to enhance therapeutic efficiency of anticancer drugs. In addition to drug delivery, nanocarriers such as liposomes, carbon nanotubes, quantum dots, polymeric nanoparticles, dendrimers, and metallic nanoparticles can be designed for detection, diagnosis, and treatment. Recent studies support the idea that a combination of two or more nanoparticle-mediated therapies can result in a synergistic therapeutic outcome to improve current cancer treatments. In this progress report, recent advances in nanoparticles-based combination therapies are discussed. A brief overview of the complexity of cancer tumor's microenvironment is presented, followed by discussion of combinatorial therapies categorized based on chemotherapeutic agents, nucleic acid or therapeutic proteins, energy-based therapies and imaging techniques for theranostic application. Different nanotechnological platforms are developed for combination therapy as tools with a great potential to tackle the most critical issues of current cancer treatments. A deeper understanding of these nanotechnologies and their possible long-term effects in biological systems is needed for further clinical translation.

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Dual responsive magnetic composite nanogels for thermo-chemotherapy

Cited by 51 publications

References 35 publications

Doxorubicin Intracellular Remote Release from Biocompatible Oligo(ethylene glycol) Methyl Ether Methacrylate-Based Magnetic Nanogels Triggered by Magnetic Hyperthermia

Doxorubicin Intracellular Remote Release from Biocompatible Oligo(ethylene glycol) Methyl Ether Methacrylate-Based Magnetic Nanogels Triggered by Magnetic Hyperthermia

Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications

Nanoparticles‐Mediated Combination Therapies for Cancer Treatment

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