Dual-responsive injectable hydrogels encapsulating drug-loaded micelles for on-demand antimicrobial activity and accelerated wound healing

Hu, Cheng; Zhang, Fanjun; Long, Linyu; Kong, Qunshou; Luo, Rifang; Wang, Yunbing

doi:10.1016/j.jconrel.2020.05.010

Cited by 157 publications

(110 citation statements)

References 78 publications

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“…7 ). The green fluorescent FDA staining can only show the live cells, while red fluorescent PI specifically stains dead bacteria with broken membranes, but the live ones with intact bacterial membranes are unstained [ 30 , 31 ]. As shown in the fluorescence images, obvious red fluorescence was seen in the CDs-treated samples and a much higher density of the dead cells was seen by the CDFs-treated samples.…”

Section: Resultsmentioning

confidence: 99%

Assembly of Carbon Dots into Frameworks with Enhanced Stability and Antibacterial Activity

Zhuang

Li²,

Daoyong³

et al. 2021

Nanoscale Res Lett

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Carbon dots (CDs) have been widely used as antimicrobials due to their active surface, but some CDs suffer instability. Therefore, the relative applications such as the antibacterial activity may not be reliable for long-term use. Herein, we synthesize CDs with blue fluorescence by a hydrothermal process. Thereafter, polyethylenimine was applied for the assembly of CDs into CDs-based frameworks (CDFs). The CDFs exhibited quenched fluorescence but showed more stable properties based on the scanning electron microscope and zeta potential investigations. Both CDs and CDFs show antibacterial activity toward Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus), but CDFs exhibited better antibacterial performance, and S. aureus could be completely inhibited with the minimum inhibitory concentration of 30 μg/mL. This reveals CDFs magnify both the stability and antibacterial activity, which would be more promising for practical applications. Graphic abstract

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Section: Resultsmentioning

confidence: 99%

Assembly of Carbon Dots into Frameworks with Enhanced Stability and Antibacterial Activity

Zhuang

Li²,

Daoyong³

et al. 2021

Nanoscale Res Lett

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“…The green uorescent FDA staining can only show the live cells while red uorescent PI can only stain dead bacteria with broken membranes, but the live ones with intact bacterial membranes are unstained. 21 As shown in the uorescence images, obvious red uorescence was seen in the CDs-treated samples and a much higher density of the dead cells was seen by the CDFs-treated samples.…”

Section: Antibacterial Investigationsmentioning

confidence: 80%

Assembly of Carbon Dots Into Frameworks With Enhanced Stability and Antibacterial Activity

Zhuang

et al. 2021

Preprint

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Carbon dots (CDs) have widely been used as antimicrobials due to their active surface, but they also suffer instability. Therefore the relative applications such as the antibacterial activity may not be reliable for long-term use. Herein, we synthesize CDs with blue fluorescence by a hydrothermal process. Thereafter, polyethylenimine (PEI) was applied for the assembly of CDs into CDs-based frameworks (CDFs). The CDFs exhibited quenched fluorescence but showed more stable properties based on the scanning electron microscope (SEM) and zeta potential investigations. Both CDs and CDFs show antibacterial activity toward Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus), but CDFs exhibited better antibacterial performance. This reveals CDFs magnify both the stability and antibacterial activity, which would be more promising for practical applications.

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“…And also, the phenylborate can react with orthodiol or 1,3‐diol to form a pH sensitive crosslinker (Figure 2). [ 30–32 ]…”

Section: Chemical Reactions Involved In the Synthesis Of Glycan Derivativesmentioning

confidence: 99%

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Niu

Xue

2021

Macromolecular Bioscience

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Inflammation is closely related to a variety of fatal or chronic diseases. Hence, targeting inflammation provides an alternative approach to improve the therapeutic outcome of diseases such as solid tumors, neurological diseases, and metabolic diseases. Polysaccharides are natural components with immune regulation, anti‐virus, anti‐cancer, anti‐inflammation, and anti‐oxidation activities. Herein, this review highlights recent progress in the polysaccharide‐based drug delivery systems for achieving inflammation targeting and its related disease treatment. Moreover, the chemical modification and the construction of polysaccharide materials for drug delivery are discussed in detail.

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Dual-responsive injectable hydrogels encapsulating drug-loaded micelles for on-demand antimicrobial activity and accelerated wound healing

Cited by 157 publications

References 78 publications

Assembly of Carbon Dots into Frameworks with Enhanced Stability and Antibacterial Activity

Assembly of Carbon Dots into Frameworks with Enhanced Stability and Antibacterial Activity

Assembly of Carbon Dots Into Frameworks With Enhanced Stability and Antibacterial Activity

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

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