Dual‐Pore Mesoporous Carbon@Silica Composite Core–Shell Nanospheres for Multidrug Delivery

Abstract

Monodispersed mesoporous phenolic polymer nanospheres with uniform diameters were prepared and used as the core for the further growth of core-shell mesoporous nanorattles. The hierarchical mesoporous nanospheres have a uniform diameter of 200 nm and dual-ordered mesopores of 3.1 and 5.8 nm. The hierarchical mesostructure and amphiphilicity of the hydrophobic carbon cores and hydrophilic silica shells lead to distinct benefits in multidrug combination therapy with cisplatin and paclitaxel for the treatment of human ovarian cancer, even drug-resistant strains.Mesoporous materials have diverse applications in catalysis, energy storage, separation, and biomedicine due to their unique properties attributed to high surface area, large pore volume, and regular large pore size. [1][2][3][4][5][6] Through the control of the growth and cooperation-assembly processes in solution phase, the morphology and particle size of the products can be modified. One important and exciting advance is to fabricate nanosized particles with ordered mesostructures through controlled sol-gel procedures in solution phase. [7][8][9][10][11][12][13][14][15][16] These mesostructured nanoparticles are attractive since they combine the advantages of the quantum effect of nanosized particles and the high surface area of mesostructures, which can lead to unconventional properties.

A bioinspired strategy for surface modification of silica nanoparticles

“…The finally particles were dried in a vacuum at 60 • C for 12 h to obtain SiO 2 -PDA-poly(PEGMA-co-NAPAM). 1 H NMR spectrum of poly(PEGMA-co-NAPAM) was shown in Fig. 1.…”

“…As one of the most fascinating materials, silica nanoparticles have been applied to many areas due to their excellent properties such as high specific surface area, light translucence, controllability for fabrication and low cost [1][2][3][4][5][6]. The outstanding properties of silica nanoparticles related to their structure have drawn numerous attention from researchers to explore their applications [7][8][9][10][11][12][13].…”

Sensitive detection of adenosine triphosphate by exonuclease III-assisted cyclic amplification coupled with surface plasmon resonance enhanced fluorescence based on nanopore

“…Mesoporous silica nanoparticle (MSN) has been a useful material due to its nontoxic nature, high surface area, tunable pore size and chemically modifiable surface, which has been used as a promising carrier system for drug delivery [17] and imaging materials [18]. MSN has been applied in bioanalysis [19,20].…”

Pore formation in crystalline polymer film with organic solvent and water-pressure for applications to water-treatment and separator

“…Fabricating pores into polymer has been important and necessary in many fields, due to their versatile applications [1][2][3][4][5][6].…”