Dual (pH- and temperature-) stimuli responsive nanocarrier with bimodal mesoporous silica nanoparticles core and copolymer shell for controlled ibuprofen-releasing: Fractal feature and diffusion mechanism

Jin, Xiaoqi; Wang, Qian; Sun, Jihong; Panezai, Hamida; Bai, Shiyang; Wu, Xia

doi:10.1016/j.micromeso.2017.05.003

Cited by 53 publications

(17 citation statements)

References 49 publications

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“…2, the cumulative release rates of Bup@MSNs@P(NIPAM‐MAA) at 25, 30 and 35 °C after 14 days were 23.5%, 45.9% and 72.7%, respectively. The cumulative release rate of buprofezin significantly increased with the increase in temperature, which is consistent with the research results of other scholars using P(NIPAM‐MAA) copolymer to modify nanomaterials 37 . The variety of release rate caused by temperature may be the result of changes in polymer shape: at low temperature, the polymer molecular chain shrinks, resulting in a slow release rate; 38 at high temperature, the polymer molecular chain stretches, leading to faster release of buprofezin.…”

Section: Resultssupporting

confidence: 91%

Preparation of thermosensitive buprofezin‐loaded mesoporous silica nanoparticles by the sol–gel method and their application in pest control

Yang

Feng

et al. 2021

Pest Management Science

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BACKGROUND Environmental stimuli‐responsive release is one important way to reduce the dosage of pesticide, increase the usage efficiency and improve environmental compatibility. RESULTS On this basis, we synthesized mesoporous silica nanoparticles (MSNs) and modified them to develop a thermosensitive pesticide controlled release formulation (CRF). In this study, MSNs prepared by the sol–gel method were used as the core, poly (N‐IsoPropylAcrylaMide) [P (NIPAM‐MAA)] was used as the shell, and buprofezin (Bup) was loaded by adsorption. The prepared Bup@MSNs@P(NIPAM‐MAA) could effectively prevent the degradation of buprofezin under UV light and exhibited excellent adhesion to rice leaves. The bioassay results showed that the mortality of Nilaparvata lugens (Stål) treated by Bup@MSNs@P(NIPAM‐MAA) was positively correlated with temperature, resulting mainly from the change of release amount of buprofezin caused by temperature variation. Bup@MSNs@P(NIPAM‐MAA) had long duration (20 days) for controlling N. lugens, and did not hinder the growth of rice. Meanwhile, Bup@MSNs@P(NIPAM‐MAA) had low toxicity to zebrafish and human pneumonocyte BEAS‐2B cells. CONCLUSION This novel thermosensitive pesticide CRF can be applied widely to other insecticides, thus greatly promoting the development of intelligent pesticide formulations. © 2021 Society of Chemical Industry.

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Section: Resultssupporting

confidence: 91%

Preparation of thermosensitive buprofezin‐loaded mesoporous silica nanoparticles by the sol–gel method and their application in pest control

Yang

Feng

et al. 2021

Pest Management Science

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“…Furthermore, research studies have been published that indicated a potent and stronger drug release behavior in a further decrease in pH. For instance, Jin et al [ 16 ] studied pH-responsive mesoporous silica nanoparticles carrying ibuprofen in PBS solution with pH 7.4 and '2.0′. They reported that the drug release rate was faster at an extremely lower pH (2.0) than that at pH 7.4.…”

Section: Discussionmentioning

confidence: 99%

pH-dependent delivery of chlorhexidine from PGA grafted mesoporous silica nanoparticles at resin-dentin interface

et al. 2021

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Background A low pH environment is created due to the production of acids by oral biofilms that further leads to the dissolution of hydroxyapatite crystal in the tooth structure significantly altering the equilibrium. Although the overall bacterial counts may not be eradicated from the oral cavity, however, synthesis of engineered anti-bacterial materials are warranted to reduce the pathogenic impact of the oral biofilms. The purpose of this study was to synthesize and characterize chlorhexidine (CHX)-loaded mesoporous silica nanoparticles (MSN) grafted with poly-L-glycolic acid (PGA) and to test the in vitro drug release in various pH environments, cytotoxicity, and antimicrobial capacity. In addition, this study aimed to investigate the delivery of CHX-loaded/MSN-PGA nanoparticles through demineralized dentin tubules and how these nanoparticles interact with tooth dentin after mixing with commercial dentin adhesive for potential clinical application. Results Characterization using SEM/TEM and EDX confirmed the synthesis of CHX-loaded/MSN-PGA. An increase in the percentage of drug encapsulation efficiency from 81 to 85% in CHX loaded/MSN and 92–95% in CHX loaded/MSN-PGA proportionately increased with increasing the amount of CHX during the fabrication of nanoparticles. For both time-periods (24 h or 30 days), the relative microbial viability significantly decreased by increasing the CHX content (P < 0.001). Generally, the cell viability percentage of DPSCs exposed to MSN-PGA/Blank, CHX-loaded/MSN, and CHX-loaded/MSN-PGA, respectively was > 80% indicating low cytotoxicity profiles of experimental nanoparticles. After 9 months in artificial saliva (pH 7.4), the significantly highest micro-tensile bond strength value was recorded for 25:50 CHX/MSN and 25:50:50 CHX/MSN-PGA. A homogenous and widely distributed 50:50:50 CHX-loaded/MSN-PGA nanoparticles exhibited excellent bonding with the application of commercially available dentin adhesive. Conclusions A pH-sensitive CHX release response was noted when loaded in MSN grafted PGA nanoparticles. The formulated drug-loaded nanocarrier demonstrated excellent physicochemical, spectral, and biological characteristics. Showing considerable capacity to penetrate effectively inside dentinal tubules and having high antibacterial efficacy, this system could be potentially used in adhesive and restorative dentistry.

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“…45 and 46 ) which is consistent with the previous report. 47 Cytotoxicity study. MTT assay was performed using MDA-MB-231 cancer cells to evaluate the cytotoxicity of all the synthesized BCPs.…”

Section: Drug Loading and Release Studymentioning

confidence: 99%

RAFT polymerization mediated core–shell supramolecular assembly of PEGMA-co-stearic acid block co-polymer for efficient anticancer drug delivery

2021

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Dual (pH- and temperature-) stimuli responsive nanocarrier with bimodal mesoporous silica nanoparticles core and copolymer shell for controlled ibuprofen-releasing: Fractal feature and diffusion mechanism

Cited by 53 publications

References 49 publications

Preparation of thermosensitive buprofezin‐loaded mesoporous silica nanoparticles by the sol–gel method and their application in pest control

Preparation of thermosensitive buprofezin‐loaded mesoporous silica nanoparticles by the sol–gel method and their application in pest control

pH-dependent delivery of chlorhexidine from PGA grafted mesoporous silica nanoparticles at resin-dentin interface

RAFT polymerization mediated core–shell supramolecular assembly of PEGMA-co-stearic acid block co-polymer for efficient anticancer drug delivery

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